STRINGSTRING
TAB2 TAB2 TNF TNF MAPK12 MAPK12 TAB1 TAB1 MAPK13 MAPK13 RAC2 RAC2 IFNB1 IFNB1 PIP5K1B PIP5K1B SKAP2 SKAP2 CXCL8 CXCL8 MAP3K7 MAP3K7 IRF3 IRF3 ITGB1 ITGB1 IL2 IL2 PIK3R3 PIK3R3 MYD88 MYD88 AKT2 AKT2 RHOG RHOG RAC3 RAC3 ITGA5 ITGA5 TRAF6 TRAF6 IL1B IL1B PIK3CB PIK3CB PIK3R1 PIK3R1 MAPK10 MAPK10 CHUK CHUK IRAK4 IRAK4 LCK LCK NLRP3 NLRP3 GIT2 GIT2 IL10 IL10 NFATC2 NFATC2 ARHGEF12 ARHGEF12 WASF2 WASF2 RPS6KA1 RPS6KA1 LIMK1 LIMK1 PIP5K1A PIP5K1A DOCK1 DOCK1 RPS6KA3 RPS6KA3 WIPF1 WIPF1 RELA RELA NFKBIA NFKBIA PIK3R2 PIK3R2 CRKL CRKL AKT3 AKT3 PKN1 PKN1 PYCARD PYCARD FOS FOS LOC491949 LOC491949 LAT LAT CCL2 CCL2 AKT1 AKT1 VAV1 VAV1 CRK CRK PIP5K1C PIP5K1C GNAQ GNAQ TRAF2 TRAF2 IKBKG IKBKG PIK3CD PIK3CD FYB1 FYB1 RHOA RHOA MAPK1 MAPK1 TLR4 TLR4 NFATC1 NFATC1 MEFV MEFV TICAM1 TICAM1 GSK3B GSK3B ACTR3B ACTR3B IL18 IL18 WIPF2 WIPF2 LCP2 LCP2 ARHGEF1 ARHGEF1 ACTR3 ACTR3 MAP2K2 MAP2K2 SRC SRC MAP2K1 MAP2K1 ELMO1 ELMO1 PLCG1 PLCG1 MAPK8 MAPK8 IKBKB IKBKB MAPK14 MAPK14 PIK3CA PIK3CA TBK1 TBK1 MAP2K4 MAP2K4 PXN-2 PXN-2 ROCK1 ROCK1 RPS6KA2 RPS6KA2 ACTR2 ACTR2 PTK2 PTK2 NFATC3 NFATC3 IL6 IL6 ARF6 ARF6 ELMO2 ELMO2 PTK2B PTK2B NFKB1 NFKB1 PKN2 PKN2 BCAR1 BCAR1 MAP2K6 MAP2K6 CDC42-2 CDC42-2 MAP2K3 MAP2K3 ARHGEF7 ARHGEF7 MAPK11 MAPK11 MAPK9 MAPK9 CD4 CD4 VAV3 VAV3 ROCK2 ROCK2 ARHGEF28 ARHGEF28 WASL WASL FN1 FN1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
RAC2Rac family small GTPase 2. (192 aa)
IFNB1Interferon-beta. (186 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa)
SKAP2Src kinase associated phosphoprotein 2. (359 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRF3Interferon regulatory factor 3. (281 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
PIK3R3Uncharacterized protein. (461 aa)
MYD88MYD88 innate immune signal transduction adaptor. (398 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
RHOGRas homolog family member G. (191 aa)
RAC3Uncharacterized protein. (210 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (466 aa)
LCKTyrosine-protein kinase. (509 aa)
NLRP3NLR family pyrin domain containing 3. (1065 aa)
GIT2GIT ArfGAP 2. (759 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1543 aa)
WASF2WASP family member 2. (498 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (876 aa)
LIMK1LIM domain kinase 1. (761 aa)
PIP5K1APIPK domain-containing protein. (562 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1896 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (717 aa)
WIPF1WAS/WASL interacting protein family member 1. (510 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PIK3R2Uncharacterized protein. (726 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PKN1Protein kinase N1. (1145 aa)
PYCARDPYD and CARD domain containing. (195 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC491949Uncharacterized protein. (230 aa)
LATLinker for activation of T cells. (290 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (162 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
FYB1FYN binding protein 1. (829 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
MEFVMEFV innate immuity regulator, pyrin. (858 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
ACTR3BActin related protein 3B; Belongs to the actin family. (485 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa)
WIPF2WAS/WASL interacting protein family member 2. (440 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
ARHGEF1DH domain-containing protein. (976 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (416 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
SRCTyrosine-protein kinase. (553 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
ELMO1Engulfment and cell motility 1. (823 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TBK1TANK binding kinase 1. (772 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (413 aa)
PXN-2Uncharacterized protein. (258 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
PKN2Protein kinase N2. (1013 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (892 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
CDC42-2Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (517 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (807 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
VAV3Vav guanine nucleotide exchange factor 3. (859 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1778 aa)
WASLWASP like actin nucleation promoting factor. (524 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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