STRINGSTRING
IFNGR1 IFNGR1 TAB2 TAB2 IFNG IFNG LOC100684769 LOC100684769 TNF TNF HSPA1L HSPA1L MAPK12 MAPK12 HLA-DQB2 HLA-DQB2 HLA-DQB1 HLA-DQB1 DLA-DOA DLA-DOA TAB1 TAB1 MAPK13 MAPK13 CYCS CYCS MAP3K7 MAP3K7 ITGB1 ITGB1 PIK3CG PIK3CG MYD88 MYD88 B9D2 B9D2 AKT2 AKT2 TRAF6 TRAF6 ALOX5 ALOX5 BCL2L1 BCL2L1 CASP3 CASP3 TLR2 TLR2 IL10RB IL10RB MAPK10 MAPK10 CHUK CHUK IRAK4 IRAK4 TGFB2 TGFB2 IL10 IL10 HSPA8 HSPA8 LAMB2 LAMB2 LAMB3 LAMB3 CASP8 CASP8 LOC606863 LOC606863 IL10RA IL10RA LAMC2 LAMC2 RELA RELA NFKBIA NFKBIA CCR5 CCR5 IL12A IL12A BIRC2 BIRC2 AKT3 AKT3 HSPA2 HSPA2 GNAI1 GNAI1 TGFB3 TGFB3 IL12B IL12B PIK3R6 PIK3R6 PIK3R5 PIK3R5 AKT1 AKT1 LAMA1 LAMA1 NOS2 NOS2 SOCS1 SOCS1 CD40LG CD40LG IKBKG IKBKG GNAI3 GNAI3 MAPK1 MAPK1 TLR4 TLR4 LAMA2 LAMA2 LOC481473 LOC481473 GNAI2 GNAI2 BAD BAD XIAP XIAP PPIF PPIF JAK1 JAK1 LAMC3 LAMC3 LDLR LDLR JAK2 JAK2 IFNGR2 IFNGR2 DLA-DRA DLA-DRA MAPK8 MAPK8 IKBKB IKBKB MAPK14 MAPK14 STAT1 STAT1 LAMB1 LAMB1 TYK2 TYK2 BIRC3 BIRC3 LAMA3 LAMA3 STAT3 STAT3 PDPK1 PDPK1 ITGA6 ITGA6 LAMC1 LAMC1 NFKB1 NFKB1 LOC487739 LOC487739 LAMA4 LAMA4 CIITA CIITA MAP2K6 MAP2K6 LAMB4 LAMB4 CD40 CD40 MAP2K3 MAP2K3 TNFRSF1A TNFRSF1A MAPK11 MAPK11 MAPK9 MAPK9 CASP9 CASP9
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGR1Interferon gamma receptor 1. (475 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
LOC100684769IRG-type G domain-containing protein. (471 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (661 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (205 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
DLA-DOAMHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1104 aa)
MYD88MYD88 innate immune signal transduction adaptor. (398 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
ALOX5Arachidonate 5-lipoxygenase. (642 aa)
BCL2L1BCL2 like 1. (233 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
IL10RBInterleukin 10 receptor subunit beta. (374 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (466 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (486 aa)
LOC606863Interferon-gamma-inducible GTPase IFGGD1 protein. (397 aa)
IL10RAInterleukin 10 receptor subunit alpha. (449 aa)
LAMC2Laminin subunit gamma 2. (1196 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
BIRC2Baculoviral IAP repeat containing 2. (617 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (637 aa)
GNAI1G protein subunit alpha i1. (337 aa)
TGFB3Transforming growth factor beta 3. (457 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (874 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LAMA1Laminin subunit alpha 1. (3034 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1157 aa)
SOCS1Suppressor of cytokine signaling 1. (197 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
LAMA2Laminin subunit alpha 2. (3112 aa)
LOC481473Interferon-gamma-inducible GTPase IFGGD2 protein. (397 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
BADBCL2 associated agonist of cell death. (167 aa)
XIAPBaculoviral IAP-repeat containing protein 4. (493 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (109 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
LAMC3Laminin subunit gamma 3. (1484 aa)
LDLRLow density lipoprotein receptor. (888 aa)
JAK2Janus kinase 2. (1407 aa)
IFNGR2Uncharacterized protein. (435 aa)
DLA-DRAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
TYK2Tyrosine-protein kinase. (1173 aa)
BIRC3Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa)
LAMA3Laminin subunit alpha 3. (3355 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
LAMC1Laminin subunit gamma 1. (1528 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
LOC487739Uncharacterized protein. (363 aa)
LAMA4Laminin subunit alpha 4. (1857 aa)
CIITAClass II major histocompatibility complex transactivator. (1206 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
LAMB4Laminin subunit beta 4. (1760 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (355 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (517 aa)
TNFRSF1ATNF receptor superfamily member 1A. (752 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (489 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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