STRINGSTRING
SERPINB10 SERPINB10 SERPINB13 SERPINB13 E2R033_CANLF E2R033_CANLF RAB5B RAB5B ARG1 ARG1 IFNG IFNG TNF TNF IL1R2 IL1R2 PRKCG PRKCG CXCL8 CXCL8 PIK3R3 PIK3R3 B9D2 B9D2 RAB5A RAB5A PLCB4 PLCB4 ACTN4 ACTN4 COL4A1 COL4A1 COL4A2 COL4A2 IL1B IL1B PIK3CB PIK3CB PIK3R1 PIK3R1 CASP3 CASP3 TLR2 TLR2 PLCB2 PLCB2 SERPINB6 SERPINB6 COL4A4 COL4A4 TGFB2 TGFB2 PRKCA PRKCA COL4A5 COL4A5 IL10 IL10 LAMB2 LAMB2 LAMB3 LAMB3 LAMC2 LAMC2 RELA RELA HSPB1 HSPB1 IL12A IL12A COL3A1 COL3A1 PIK3R2 PIK3R2 VCL VCL RAB5C RAB5C COL1A1 COL1A1 TGFB3 TGFB3 IL12B IL12B PRKCB PRKCB LAMA1 LAMA1 C9 C9 NOS2 NOS2 C8B C8B GNAQ GNAQ PIK3CD PIK3CD COL1A2 COL1A2 PRKACB PRKACB TLR4 TLR4 LAMA2 LAMA2 CSF2 CSF2 PLCB3 PLCB3 COL4A6 COL4A6 LAMC3 LAMC3 COL4A3 COL4A3 GNA14 GNA14 CTSG CTSG IL1R1 IL1R1 ENSCAFP00000046095 ENSCAFP00000046095 ACTN1 ACTN1 PIK3CA PIK3CA LAMB1 LAMB1 C8A C8A GNA11 GNA11 LAMA3 LAMA3 PTK2 PTK2 IL6 IL6 GNAL GNAL PRKACA PRKACA LAMC1 LAMC1 NFKB1 NFKB1 PRDX1 PRDX1 LAMA4 LAMA4 PLCB1 PLCB1 LAMB4 LAMB4 RAB7B RAB7B FN1 FN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINB10Serpin family B member 10; Belongs to the serpin family. (397 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (433 aa)
E2R033_CANLFSERPIN domain-containing protein; Belongs to the serpin family. (389 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
ARG1Arginase. (322 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1R2Interleukin 1 receptor type 2. (595 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
PIK3R3Uncharacterized protein. (461 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ACTN4Actinin alpha 4. (1163 aa)
COL4A1Collagen type IV alpha 1 chain. (1586 aa)
COL4A2Collagen type IV alpha 2 chain. (329 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
SERPINB6Serpin family B member 6; Belongs to the serpin family. (379 aa)
COL4A4Collagen type IV alpha 4 chain. (1688 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
COL4A5Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1691 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
LAMC2Laminin subunit gamma 2. (1196 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
HSPB1Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. (206 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
COL3A1Collagen type III alpha 1 chain. (1539 aa)
PIK3R2Uncharacterized protein. (726 aa)
VCLVinculin. (1147 aa)
RAB5CRas-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (216 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1460 aa)
TGFB3Transforming growth factor beta 3. (457 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
LAMA1Laminin subunit alpha 1. (3034 aa)
C9Complement C9. (568 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1157 aa)
C8BComplement C8 beta chain. (590 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1366 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
LAMA2Laminin subunit alpha 2. (3112 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
COL4A6Collagen type IV alpha 6 chain. (1707 aa)
LAMC3Laminin subunit gamma 3. (1484 aa)
COL4A3Collagen type IV alpha 3 chain. (1692 aa)
GNA14G protein subunit alpha 14. (359 aa)
CTSGGranzyme B; Belongs to the peptidase S1 family. (351 aa)
IL1R1Interleukin 1 receptor type 1. (629 aa)
ENSCAFP00000046095Uncharacterized protein. (1555 aa)
ACTN1Actinin alpha 1. (956 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
C8AComplement C8 alpha chain. (608 aa)
GNA11Uncharacterized protein. (89 aa)
LAMA3Laminin subunit alpha 3. (3355 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa)
GNALG protein subunit alpha L. (462 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
LAMC1Laminin subunit gamma 1. (1528 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
PRDX1Thioredoxin domain-containing protein. (280 aa)
LAMA4Laminin subunit alpha 4. (1857 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
LAMB4Laminin subunit beta 4. (1760 aa)
RAB7BRAB7B, member RAS oncogene family. (222 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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