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| | RAB5B | RAB5B, member RAS oncogene family. (215 aa) |
| | MALT1 | MALT1 paracaspase. (758 aa) |
| | IL23A | Interleukin 23 subunit alpha. (193 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (475 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (366 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 1. (205 aa) |
| | HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 2. (303 aa) |
| | DLA-DOA | MHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa) |
| | EP300 | E1A binding protein p300. (2308 aa) |
| | HSPA9 | Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (695 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (346 aa) |
| | IFNB1 | Interferon-beta. (186 aa) |
| | CALM2 | Calmodulin 1; Belongs to the calmodulin family. (149 aa) |
| | NFYC | Nuclear transcription factor Y subunit gamma. (335 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (180 aa) |
| | SPHK2 | Sphingosine kinase 2. (733 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa) |
| | F1PIN6_CANLF | Uncharacterized protein; Belongs to the calmodulin family. (364 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (768 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | MYD88 | MYD88 innate immune signal transduction adaptor. (398 aa) |
| | B9D2 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | SPHK1 | Sphingosine kinase 1. (487 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (621 aa) |
| | CALML5 | Calmodulin like 5. (169 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | RAB5A | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa) |
| | EEA1 | Early endosome antigen 1. (1406 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (413 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (147 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (374 aa) |
| | VDR | Vitamin D receptor. (432 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1441 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (466 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | CTSD | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (410 aa) |
| | LSP1 | Lymphocyte specific protein 1. (368 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | HSPD1 | 60 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa) |
| | FCGR1A | Uncharacterized protein. (428 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1543 aa) |
| | CTSS | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). (339 aa) |
| | CAMK2D | Calcium/calmodulin dependent protein kinase II delta. (533 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (486 aa) |
| | RFX5 | Regulatory factor X5. (619 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (449 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (86 aa) |
| | CAMP | Cathelicidin antimicrobial peptide. (172 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (542 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (226 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | RFXANK | Regulatory factor X associated ankyrin containing protein. (260 aa) |
| | RAB5C | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (216 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | TLR6 | Toll like receptor 6; Belongs to the Toll-like receptor family. (797 aa) |
| | TGFB3 | Transforming growth factor beta 3. (457 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | CALML4 | Calmodulin like 4. (120 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | C3 | Complement C3. (1566 aa) |
| | KSR1 | Kinase suppressor of ras 1. (928 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1157 aa) |
| | CALML6 | Calmodulin like 6. (156 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (465 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (536 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) |
| | TIRAP | TIR domain containing adaptor protein. (406 aa) |
| | TLR9-2 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa) |
| | TLR1 | Toll like receptor 1; Belongs to the Toll-like receptor family. (760 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1250 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa) |
| | RFXAP | Regulatory factor X associated protein. (233 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | CD209 | C-type lectin domain-containing protein. (277 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (540 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (207 aa) |
| | J9P9F2_CANLF | CaMKII_AD domain-containing protein. (241 aa) |
| | JAK2 | Janus kinase 2. (1407 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (534 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | IFNGR2 | Uncharacterized protein. (435 aa) |
| | DLA-DRA | Ig-like domain-containing protein; Belongs to the MHC class II family. (342 aa) |
| | LOC100683416 | Uncharacterized protein. (178 aa) |
| | IFNA5 | Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | LOC100687692 | Uncharacterized protein. (187 aa) |
| | LOC100683202 | Interferon alpha-1/2; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | STAT1 | Signal transducer and activator of transcription. (774 aa) |
| | BID | BH3 interacting domain death agonist. (287 aa) |
| | LOC100686162 | Uncharacterized protein. (175 aa) |
| | IFNA7 | Interferon-alpha. (187 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (470 aa) |
| | LOC100687857 | Uncharacterized protein. (187 aa) |
| | SYK | Tyrosine-protein kinase. (699 aa) |
| | ATP6V1H | ATPase H+ transporting V1 subunit H. (577 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa) |
| | LOC487739 | Uncharacterized protein. (363 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1206 aa) |
| | CAMK2G | Calcium/calmodulin dependent protein kinase II gamma. (611 aa) |
| | LOC478984 | Uncharacterized protein. (286 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | MRC1 | Mannose receptor C-type 1. (1436 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (863 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (752 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (231 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (489 aa) |
| | LOC100683567 | Uncharacterized protein. (196 aa) |
| | PPP3R1 | Uncharacterized protein. (169 aa) |
