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| | STAT2 | Signal transducer and activator of transcription. (844 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | HSPA1L | Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (661 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (243 aa) |
| | IL2RB | Fibronectin type-III domain-containing protein. (556 aa) |
| | IFNB1 | Interferon-beta. (186 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | IRF3 | Interferon regulatory factor 3. (281 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (180 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | MYD88 | MYD88 innate immune signal transduction adaptor. (398 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2. (532 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (520 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1113 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (373 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (399 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1140 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (717 aa) |
| | LOC609830 | Uncharacterized protein. (569 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (399 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (466 aa) |
| | CBLB | Cbl proto-oncogene B. (1004 aa) |
| | HSPA8 | Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa) |
| | RAB9A | Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Belongs to the small GTPase superfamily. Rab family. (201 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (486 aa) |
| | SLAMF1 | Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those [...] (342 aa) |
| | RACK1 | Receptor for activated C kinase 1. (317 aa) |
| | CD3G | CD3g molecule. (182 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (542 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | LOC102156626 | Uncharacterized protein. (312 aa) |
| | FASLG | Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (286 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | CCND2 | Cyclin D2; Belongs to the cyclin family. (328 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa) |
| | FAS | Fas cell surface death receptor. (734 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (637 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | ADAR | Adenosine deaminase RNA specific. (929 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | RAB9B | RAB9B, member RAS oncogene family. (228 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | TLR9-2 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | LOC609365 | Uncharacterized protein. (395 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1250 aa) |
| | EIF3H | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (365 aa) |
| | CD3D | CD3d molecule. (194 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (259 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | CD209 | C-type lectin domain-containing protein. (277 aa) |
| | IL2RG | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa) |
| | LOC100683416 | Uncharacterized protein. (178 aa) |
| | IFNA5 | Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | LOC100687692 | Uncharacterized protein. (187 aa) |
| | LOC100683202 | Interferon alpha-1/2; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2. (571 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | STAT1 | Signal transducer and activator of transcription. (774 aa) |
| | TBK1 | TANK binding kinase 1. (772 aa) |
| | IFNAR1 | Uncharacterized protein. (572 aa) |
| | TYK2 | Tyrosine-protein kinase. (1173 aa) |
| | STAT3 | Signal transducer and activator of transcription. (793 aa) |
| | MX1 | Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV). (791 aa) |
| | BID | BH3 interacting domain death agonist. (287 aa) |
| | CD28 | CD28 molecule. (246 aa) |
| | LOC100686162 | Uncharacterized protein. (175 aa) |
| | IFNA7 | Interferon-alpha. (187 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa) |
| | BBC3 | Uncharacterized protein. (293 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa) |
| | LOC100687857 | Uncharacterized protein. (187 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa) |
| | IFNAR2 | Uncharacterized protein. (522 aa) |
| | MSN | Moesin. (592 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (380 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (489 aa) |
| | LOC100683567 | Uncharacterized protein. (196 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa) |
