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| | PARD6G | Par-6 family cell polarity regulator gamma. (385 aa) |
| | STAT2 | Signal transducer and activator of transcription. (844 aa) |
| | TBPL1 | Uncharacterized protein. (186 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (1011 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] (1099 aa) |
| | DLA88 | DLA class I histocompatibility antigen, A9/A9 alpha chain; Involved in the presentation of foreign antigens to the immune system. (361 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | FZD6 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (712 aa) |
| | TNXB | Tenascin XB. (3966 aa) |
| | IRF1 | Interferon regulatory factor 1. (437 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (243 aa) |
| | EP300 | E1A binding protein p300. (2308 aa) |
| | MFNG | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (315 aa) |
| | ATP6V1F | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa) |
| | IFNB1 | Interferon-beta. (186 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (680 aa) |
| | NFX1 | Nuclear transcription factor, X-box binding 1. (1118 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (651 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | COL9A1 | Collagen type IX alpha 1 chain. (921 aa) |
| | COL9A2 | Collagen type IX alpha 2 chain. (664 aa) |
| | ATP6V1B1 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. (531 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1141 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (280 aa) |
| | IRF3 | Interferon regulatory factor 3. (281 aa) |
| | MAML3 | Mastermind like transcriptional coactivator 3. (1098 aa) |
| | PARD3 | Par-3 family cell polarity regulator. (1258 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (820 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (180 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | ATP6V0E2 | V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa) |
| | ITGA8 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (993 aa) |
| | LLGL2 | LLGL scribble cell polarity complex component 2. (1022 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | CTNNB1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (205 aa) |
| | FOXO1 | Forkhead box O1. (654 aa) |
| | COL6A5 | Collagen type VI alpha 5 chain. (2603 aa) |
| | COL6A6 | Collagen type VI alpha 6 chain. (2268 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2. (532 aa) |
| | COL4A1 | Collagen type IV alpha 1 chain. (1586 aa) |
| | COL4A2 | Collagen type IV alpha 2 chain. (329 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (118 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1152 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (373 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (588 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] (276 aa) |
| | THBS1 | Thrombospondin 1. (1456 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1488 aa) |
| | LOC609830 | Uncharacterized protein. (569 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (519 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (399 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | IBSP | Integrin binding sialoprotein. (319 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | ATP6V1B2 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa) |
| | COL4A4 | Collagen type IV alpha 4 chain. (1688 aa) |
| | OASL | 2'-5' oligoadenylate synthetase-like 1. (515 aa) |
| | OASL-2 | Oligoadenylate synthetase-like 2. (519 aa) |
| | NOTCH2 | Notch receptor 2. (2726 aa) |
| | ATP6V1A | ATPase H+ transporting V1 subunit A. (618 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | ATP6V1G3 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | COL4A5 | Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1691 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa) |
| | LAMB2 | Laminin subunit beta 2. (1801 aa) |
| | LAMB3 | Laminin subunit beta 3. (1172 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (486 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (718 aa) |
| | COL6A3 | Collagen type VI alpha 3 chain. (3169 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (594 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa) |
| | LAMC2 | Laminin subunit gamma 2. (1196 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (542 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | LOC610614 | Uncharacterized protein. (2364 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (771 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (433 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa) |
| | TNN | Tenascin N. (1441 aa) |
| | FASLG | Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (286 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa) |
| | TUBG1 | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). (451 aa) |
| | CHD4 | Chromodomain helicase DNA binding protein 4. (1984 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | TBPL2 | TATA-box binding protein like 2. (376 aa) |
| | UBR4 | Ubiquitin protein ligase E3 component n-recognin 4. (5192 aa) |
| | CCND2 | Cyclin D2; Belongs to the cyclin family. (328 aa) |
| | FAS | Fas cell surface death receptor. (734 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | NOTCH3 | Notch receptor 3. (2148 aa) |
| | ATP6V1E1 | Uncharacterized protein. (226 aa) |
| | MPP5 | MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebell [...] (675 aa) |
| | ATP6V1D | ATPase H+ transporting V1 subunit D. (385 aa) |
| | LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (248 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (466 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa) |
| | COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1460 aa) |
| | THBS3 | Thrombospondin 3. (956 aa) |
| | CHAD | Chondroadherin. (359 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | LLGL1 | LLGL scribble cell polarity complex component 1. (1201 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa) |
| | LAMA1 | Laminin subunit alpha 1. (3034 aa) |
| | VTN | SMB domain-containing protein. (524 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | ISG15 | ISG15 ubiquitin like modifier. (168 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (165 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2072 aa) |
| | HES3 | Hes family bHLH transcription factor 3. (175 aa) |
| | HES2 | Hes family bHLH transcription factor 2. (241 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (465 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | NOTCH1 | Notch receptor 1. (2565 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | COL1A2 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1366 aa) |
| | TSC1 | TSC complex subunit 1. (1169 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (910 aa) |
| | LAMA2 | Laminin subunit alpha 2. (3112 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (310 aa) |
| | TADA3 | Transcriptional adaptor 3. (432 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (919 aa) |
| | TICAM1 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | RELN | Reelin. (3459 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | TNR | Tenascin R. (1358 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | J9NTK7_CANLF | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (99 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (510 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (508 aa) |
| | COL4A6 | Collagen type IV alpha 6 chain. (1707 aa) |
| | DLG3-2 | SH3 domain-containing protein. (185 aa) |
| | ITGB4 | Integrin beta. (1766 aa) |
| | TSC2 | TSC complex subunit 2. (1783 aa) |
| | ITGA9 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1063 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (339 aa) |
| | HES7 | Hes family bHLH transcription factor 7. (345 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa) |
| | ATP6V0E1 | V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (565 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | PARD6A | Par-6 family cell polarity regulator alpha. (514 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (427 aa) |
| | LAMC3 | Laminin subunit gamma 3. (1484 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | COL4A3 | Collagen type IV alpha 3 chain. (1692 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (495 aa) |
| | COL6A1 | Collagen type VI alpha 1 chain. (1089 aa) |
| | HDAC2 | Histone deacetylase 2. (604 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (382 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa) |
| | TCF7 | Transcription factor 7. (484 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (571 aa) |
| | CRB3 | Crumbs cell polarity complex component 3. (123 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa) |
| | LOC100683416 | Uncharacterized protein. (178 aa) |
| | IFNA5 | Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (471 aa) |
| | PTGER4 | Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (610 aa) |
| | LOC100687692 | Uncharacterized protein. (187 aa) |
| | LOC100683202 | Interferon alpha-1/2; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (1012 aa) |
| | ATP6V1G2 | V-type proton ATPase subunit G 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (242 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (525 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa) |
| | STAT1 | Signal transducer and activator of transcription. (774 aa) |
| | APC | APC regulator of WNT signaling pathway. (2851 aa) |
| | LAMB1 | Laminin subunit beta 1. (1785 aa) |
| | TBK1 | TANK binding kinase 1. (772 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (250 aa) |
| | IFNAR1 | Uncharacterized protein. (572 aa) |
| | PXN-2 | Uncharacterized protein. (258 aa) |
| | TYK2 | Tyrosine-protein kinase. (1173 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (357 aa) |
| | RHEB | Ras homolog, mTORC1 binding. (232 aa) |
| | LAMA3 | Laminin subunit alpha 3. (3355 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (475 aa) |
| | THBS2 | Thrombospondin 2. (1170 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1033 aa) |
| | CSNK1A1 | Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (415 aa) |
| | SCRIB | Scribble planar cell polarity protein. (1568 aa) |
| | MX1 | Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV). (791 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa) |
| | LOC100686162 | Uncharacterized protein. (175 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (619 aa) |
| | IFNA7 | Interferon-alpha. (187 aa) |
| | VWF | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (3256 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (590 aa) |
| | THBS4 | Thrombospondin 4. (1038 aa) |
| | ITGA2B | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1194 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa) |
| | ITGB7 | Integrin beta; Belongs to the integrin beta chain family. (734 aa) |
| | ITGA6 | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa) |
| | LAMC1 | Laminin subunit gamma 1. (1528 aa) |
| | AXIN1 | Axin 1. (992 aa) |
| | LOC100687857 | Uncharacterized protein. (187 aa) |
| | PATJ | PATJ crumbs cell polarity complex component. (1884 aa) |
| | PELO | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1208 aa) |
| | ATP6V1H | ATPase H+ transporting V1 subunit H. (577 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa) |
| | RB1 | RB transcriptional corepressor 1. (927 aa) |
| | LAMA4 | Laminin subunit alpha 4. (1857 aa) |
| | IFNAR2 | Uncharacterized protein. (522 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1162 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (811 aa) |
| | CDC42-2 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa) |
| | LAMB4 | Laminin subunit beta 4. (1760 aa) |
| | CREB5 | cAMP responsive element binding protein 5. (552 aa) |
| | ITGA11 | Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1209 aa) |
| | PPP2R3B | Protein phosphatase 2 regulatory subunit B''beta. (695 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (919 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (380 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (521 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (863 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (752 aa) |
| | ATP6V1C1 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (436 aa) |
| | ATP6V1C2 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa) |
| | LOC100683567 | Uncharacterized protein. (196 aa) |
| | ITGA7 | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1186 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (513 aa) |
| | PKM | Multifunctional fusion protein; Belongs to the pyruvate kinase family. (1112 aa) |
| | TBP | TATA-box binding protein. (324 aa) |
| | ITGA10 | Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1178 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (529 aa) |
| | FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa) |
