STRINGSTRING
DCC DCC BAK1 BAK1 MYC MYC RAC2 RAC2 MSH2 MSH2 CYCS CYCS TGFA TGFA EGFR EGFR BAX BAX PIK3R3 PIK3R3 MLH1 MLH1 RALB RALB RAF1 RAF1 B9D2 B9D2 CTNNB1 CTNNB1 AKT2 AKT2 RAC3 RAC3 SOS1 SOS1 PIK3CB PIK3CB PIK3R1 PIK3R1 CASP3 CASP3 TCF7L1 TCF7L1 APPL1 APPL1 MSH3 MSH3 POLK POLK MAPK10 MAPK10 NRAS NRAS TGFB2 TGFB2 EGF EGF SOS2 SOS2 PIK3R2 PIK3R2 ARAF ARAF AKT3 AKT3 MTOR MTOR FOS FOS TGFB3 TGFB3 SMAD3 SMAD3 RPS6KB1 RPS6KB1 AKT1 AKT1 GADD45B GADD45B APC2 APC2 PIK3CD PIK3CD RHOA RHOA MAPK1 MAPK1 PMAIP1 PMAIP1 BAD BAD GSK3B GSK3B RPS6KB2 RPS6KB2 RALA RALA EREG EREG AREG AREG TCF7L2 TCF7L2 HRAS HRAS TGFBR1 TGFBR1 MSH6 MSH6 MAP2K2 MAP2K2 TCF7 TCF7 MAP2K1 MAP2K1 BIRC5 BIRC5 GADD45A GADD45A MAPK8 MAPK8 PIK3CA PIK3CA APC APC GRB2 GRB2 CDKN1A CDKN1A SMAD4 SMAD4 BBC3 BBC3 AXIN1 AXIN1 RALGDS RALGDS CCND1 CCND1 TGFBR2 TGFBR2 MAPK9 MAPK9 CASP9 CASP9 TP53 TP53 SMAD2 SMAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCCDCC netrin 1 receptor. (1416 aa)
BAK1BCL2 antagonist/killer 1. (243 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
RAC2Rac family small GTPase 2. (192 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TGFAEGF-like domain-containing protein. (284 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
BAXBCL2 associated X, apoptosis regulator. (180 aa)
PIK3R3Uncharacterized protein. (461 aa)
MLH1MutL homolog 1. (757 aa)
RALBRAS like proto-oncogene B. (206 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
RAC3Uncharacterized protein. (210 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
MSH3MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (1058 aa)
POLKDNA polymerase kappa. (861 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NRASUncharacterized protein. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
PIK3R2Uncharacterized protein. (726 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (605 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TGFB3Transforming growth factor beta 3. (457 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
APC2APC regulator of WNT signaling pathway 2. (2072 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. (54 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (510 aa)
RALARAS like proto-oncogene A. (206 aa)
EREGEpiregulin. (160 aa)
AREGAmphiregulin. (275 aa)
TCF7L2Transcription factor 7 like 2. (565 aa)
HRASUncharacterized protein. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
TCF7Transcription factor 7. (484 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (533 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (246 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
APCAPC regulator of WNT signaling pathway. (2851 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BBC3Uncharacterized protein. (293 aa)
AXIN1Axin 1. (992 aa)
RALGDSUncharacterized protein. (1045 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (489 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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