STRINGSTRING
RAP1B RAP1B EP300 EP300 SLC2A1 SLC2A1 EPAS1 EPAS1 TGFA TGFA GAB1 GAB1 PIK3R3 PIK3R3 RAF1 RAF1 PAK3 PAK3 B9D2 B9D2 VHL VHL AKT2 AKT2 PAK5 PAK5 SOS1 SOS1 HGF HGF PIK3CB PIK3CB PIK3R1 PIK3R1 ELOC ELOC PTPN11 PTPN11 PAK6 PAK6 NRAS NRAS TGFB2 TGFB2 EGLN1 EGLN1 SOS2 SOS2 PIK3R2 PIK3R2 ARAF ARAF CRKL CRKL FH FH TFE3 TFE3 AKT3 AKT3 PRCC PRCC TGFB3 TGFB3 AKT1 AKT1 FLCN FLCN CRK CRK ELOB ELOB PIK3CD PIK3CD MAPK1 MAPK1 BAD BAD CREBBP CREBBP HRAS HRAS RAP1A RAP1A MET MET VEGFA VEGFA EGLN3 EGLN3 MAP2K2 MAP2K2 ETS1 ETS1 PAK1 PAK1 MAP2K1 MAP2K1 EGLN2 EGLN2 PIK3CA PIK3CA GRB2 GRB2 CDKN1A CDKN1A RBX1 RBX1 RAPGEF1 RAPGEF1 PDGFB PDGFB CDC42-2 CDC42-2 CUL2 CUL2 ARNT2 ARNT2 PAK2 PAK2 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
EP300E1A binding protein p300. (2308 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (807 aa)
EPAS1Endothelial PAS domain protein 1. (868 aa)
TGFAEGF-like domain-containing protein. (284 aa)
GAB1GRB2 associated binding protein 1. (701 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PAK3P21 (RAC1) activated kinase 3. (583 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
VHLVon Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity). (219 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
HGFHepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
NRASUncharacterized protein. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (128 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
PIK3R2Uncharacterized protein. (726 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (605 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FHFumarate hydratase. (508 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (571 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRCCProline rich mitotic checkpoint control factor. (489 aa)
TGFB3Transforming growth factor beta 3. (457 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (748 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
ELOBElongin B. (115 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BADBCL2 associated agonist of cell death. (167 aa)
CREBBPCREB binding protein. (2442 aa)
HRASUncharacterized protein. (189 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1421 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (495 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (262 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
ETS1ETS proto-oncogene 1, transcription factor. (519 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (414 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
RBX1Ring-box 1. (108 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1297 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa)
CDC42-2Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
CUL2Cullin 2; Belongs to the cullin family. (757 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (783 aa)
PAK2Non-specific serine/threonine protein kinase. (718 aa)
HIF1AUncharacterized protein. (823 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.