STRINGSTRING
BAK1 BAK1 MYC MYC EGFR EGFR FOXO3 FOXO3 BAX BAX PIK3R3 PIK3R3 MLH1 MLH1 RAF1 RAF1 CTNNB1 CTNNB1 AKT2 AKT2 SOS1 SOS1 PIK3CB PIK3CB PIK3R1 PIK3R1 TCF7L1 TCF7L1 POLK POLK NRAS NRAS EGF EGF CTNNA3 CTNNA3 SOS2 SOS2 PIK3R2 PIK3R2 ARAF ARAF ELK1 ELK1 AKT3 AKT3 ERBB2 ERBB2 AKT1 AKT1 GADD45B GADD45B APC2 APC2 PIK3CD PIK3CD LOC489647 LOC489647 CDH1 CDH1 MAPK1 MAPK1 ILK ILK BAD BAD GSK3B GSK3B TCF7L2 TCF7L2 HRAS HRAS MAP2K2 MAP2K2 TCF7 TCF7 PTEN PTEN MAP2K1 MAP2K1 GADD45A GADD45A PIK3CA PIK3CA APC APC GRB2 GRB2 CDKN1A CDKN1A PDPK1 PDPK1 AXIN1 AXIN1 CTNNA1 CTNNA1 CTNNA2 CTNNA2 CCND1 CCND1 CASP9 CASP9 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAK1BCL2 antagonist/killer 1. (243 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
FOXO3Forkhead box O3. (671 aa)
BAXBCL2 associated X, apoptosis regulator. (180 aa)
PIK3R3Uncharacterized protein. (461 aa)
MLH1MutL homolog 1. (757 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
POLKDNA polymerase kappa. (861 aa)
NRASUncharacterized protein. (189 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa)
CTNNA3Catenin alpha 3. (895 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
PIK3R2Uncharacterized protein. (726 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (605 aa)
ELK1ETS transcription factor ELK1. (515 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1263 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
APC2APC regulator of WNT signaling pathway 2. (2072 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
LOC489647Uncharacterized protein. (513 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. (885 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ILKIntegrin linked kinase. (452 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
TCF7L2Transcription factor 7 like 2. (565 aa)
HRASUncharacterized protein. (189 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
TCF7Transcription factor 7. (484 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (246 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
APCAPC regulator of WNT signaling pathway. (2851 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
AXIN1Axin 1. (992 aa)
CTNNA1Catenin alpha 1. (918 aa)
CTNNA2Catenin alpha 2. (953 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (489 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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