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CDK4 CDK4 RXRB RXRB BAK1 BAK1 MYC MYC CDK6 CDK6 CYCS CYCS ITGB1 ITGB1 BAX BAX PIK3R3 PIK3R3 AKT2 AKT2 COL4A1 COL4A1 COL4A2 COL4A2 TRAF6 TRAF6 BCL2L1 BCL2L1 FHIT FHIT PIK3CB PIK3CB CCNE1 CCNE1 PIK3R1 PIK3R1 CASP3 CASP3 POLK POLK CCNE2 CCNE2 CHUK CHUK COL4A4 COL4A4 COL4A5 COL4A5 LAMB2 LAMB2 LAMB3 LAMB3 CDKN1B CDKN1B LAMC2 LAMC2 E2F2 E2F2 RELA RELA NFKBIA NFKBIA PTGS2 PTGS2 PIK3R2 PIK3R2 BIRC2 BIRC2 AKT3 AKT3 MAX MAX ITGA3 ITGA3 TRAF3 TRAF3 AKT1 AKT1 ITGA2 ITGA2 LAMA1 LAMA1 NOS2 NOS2 SKP2 SKP2 TRAF4 TRAF4 GADD45B GADD45B TRAF2 TRAF2 IKBKG IKBKG PIK3CD PIK3CD TRAF1 TRAF1 LAMA2 LAMA2 XIAP XIAP APAF1 APAF1 COL4A6 COL4A6 LAMC3 LAMC3 E2F3 E2F3 COL4A3 COL4A3 PTEN PTEN GADD45A GADD45A IKBKB IKBKB PIK3CA PIK3CA LAMB1 LAMB1 BIRC3 BIRC3 CDKN1A CDKN1A LAMA3 LAMA3 ITGAV ITGAV RXRG RXRG PTK2 PTK2 ITGA2B ITGA2B ITGA6 ITGA6 LAMC1 LAMC1 NFKB1 NFKB1 RB1 RB1 LAMA4 LAMA4 RXRA RXRA LAMB4 LAMB4 CKS1B CKS1B CCND1 CCND1 CASP9 CASP9 TP53 TP53 FN1 FN1 RARB RARB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RXRBRetinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily. (536 aa)
BAK1BCL2 antagonist/killer 1. (243 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
BAXBCL2 associated X, apoptosis regulator. (180 aa)
PIK3R3Uncharacterized protein. (461 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
COL4A1Collagen type IV alpha 1 chain. (1586 aa)
COL4A2Collagen type IV alpha 2 chain. (329 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
BCL2L1BCL2 like 1. (233 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (373 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
POLKDNA polymerase kappa. (861 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (399 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
COL4A4Collagen type IV alpha 4 chain. (1688 aa)
COL4A5Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1691 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
LAMC2Laminin subunit gamma 2. (1196 aa)
E2F2E2F transcription factor 2. (505 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PIK3R2Uncharacterized protein. (726 aa)
BIRC2Baculoviral IAP repeat containing 2. (617 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAXMYC associated factor X. (160 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
LAMA1Laminin subunit alpha 1. (3034 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1157 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
TRAF4TNF receptor associated factor 4. (195 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
TRAF1TNF receptor associated factor 1. (368 aa)
LAMA2Laminin subunit alpha 2. (3112 aa)
XIAPBaculoviral IAP-repeat containing protein 4. (493 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1250 aa)
COL4A6Collagen type IV alpha 6 chain. (1707 aa)
LAMC3Laminin subunit gamma 3. (1484 aa)
E2F3E2F transcription factor 3. (340 aa)
COL4A3Collagen type IV alpha 3 chain. (1692 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (246 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
BIRC3Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
LAMA3Laminin subunit alpha 3. (3355 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1033 aa)
RXRGRetinoid X receptor gamma. (538 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1194 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
LAMC1Laminin subunit gamma 1. (1528 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
RB1RB transcriptional corepressor 1. (927 aa)
LAMA4Laminin subunit alpha 4. (1857 aa)
RXRARetinoid X receptor alpha. (556 aa)
LAMB4Laminin subunit beta 4. (1760 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (489 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa)
RARBRetinoic acid receptor beta. (464 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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