STRINGSTRING
CDK4 CDK4 RXRB RXRB BAK1 BAK1 CDK6 CDK6 PRKCG PRKCG TGFA TGFA EGFR EGFR FOXO3 FOXO3 BAX BAX PIK3R3 PIK3R3 RAF1 RAF1 ALK ALK AKT2 AKT2 SOS1 SOS1 HGF HGF FHIT FHIT PIK3CB PIK3CB PIK3R1 PIK3R1 POLK POLK NRAS NRAS RASSF1 RASSF1 PRKCA PRKCA EGF EGF E2F2 E2F2 SOS2 SOS2 PIK3R2 PIK3R2 ARAF ARAF STAT5A STAT5A STAT5B STAT5B AKT3 AKT3 ERBB2 ERBB2 PRKCB PRKCB AKT1 AKT1 GADD45B GADD45B PIK3CD PIK3CD PLCG2 PLCG2 MAPK1 MAPK1 BAD BAD HRAS HRAS E2F3 E2F3 MET MET JAK3 JAK3 STK4 STK4 MAP2K2 MAP2K2 MAP2K1 MAP2K1 GADD45A GADD45A PLCG1 PLCG1 PIK3CA PIK3CA GRB2 GRB2 CDKN1A CDKN1A STAT3 STAT3 RXRG RXRG RASSF5 RASSF5 PDPK1 PDPK1 RB1 RB1 RXRA RXRA EML4 EML4 CCND1 CCND1 CASP9 CASP9 TP53 TP53 RARB RARB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RXRBRetinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily. (536 aa)
BAK1BCL2 antagonist/killer 1. (243 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TGFAEGF-like domain-containing protein. (284 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
FOXO3Forkhead box O3. (671 aa)
BAXBCL2 associated X, apoptosis regulator. (180 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ALKTyrosine-protein kinase receptor. (1631 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
HGFHepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
POLKDNA polymerase kappa. (861 aa)
NRASUncharacterized protein. (189 aa)
RASSF1Ras association domain family member 1. (344 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa)
E2F2E2F transcription factor 2. (505 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
PIK3R2Uncharacterized protein. (726 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (605 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1263 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BADBCL2 associated agonist of cell death. (167 aa)
HRASUncharacterized protein. (189 aa)
E2F3E2F transcription factor 3. (340 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1421 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
STK4Serine/threonine kinase 4. (514 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (246 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
RXRGRetinoid X receptor gamma. (538 aa)
RASSF5Ras association domain family member 5. (434 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
RB1RB transcriptional corepressor 1. (927 aa)
RXRARetinoid X receptor alpha. (556 aa)
EML4EMAP like 4. (1006 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (489 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
RARBRetinoic acid receptor beta. (464 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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