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| | FZD6 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (712 aa) |
| | RXRB | Retinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily. (536 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (243 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (651 aa) |
| | SHC3 | SHC adaptor protein 3. (458 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1141 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (280 aa) |
| | GAB1 | GRB2 associated binding protein 1. (701 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (180 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | B9D2 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | CTNNB1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (557 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa) |
| | CDX2 | Caudal type homeobox 2. (463 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (373 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (588 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | CDH17 | Cadherin 17. (832 aa) |
| | POLK | DNA polymerase kappa. (861 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (399 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | FGF8 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). (203 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1583 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (718 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (594 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa) |
| | CTNNA3 | Catenin alpha 3. (895 aa) |
| | E2F2 | E2F transcription factor 2. (505 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa) |
| | LOC480786 | C-type lectin domain-containing protein. (158 aa) |
| | SHC4 | SHC adaptor protein 4. (632 aa) |
| | FGF7 | Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). (194 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (605 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (312 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | JUP | Uncharacterized protein. (744 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | ERBB2 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1263 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa) |
| | TGFB3 | Transforming growth factor beta 3. (457 aa) |
| | SHC1 | SHC adaptor protein 1. (577 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (611 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2072 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | SHC2 | Uncharacterized protein. (636 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | LOC489647 | Uncharacterized protein. (513 aa) |
| | CDH1 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. (885 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (910 aa) |
| | FGF5 | Fibroblast growth factor 5; Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. (559 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (510 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (339 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (565 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | E2F3 | E2F transcription factor 3. (340 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1421 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa) |
| | TCF7 | Transcription factor 7. (484 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (471 aa) |
| | ENSCAFP00000046095 | Uncharacterized protein. (1555 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (246 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (214 aa) |
| | APC | APC regulator of WNT signaling pathway. (2851 aa) |
| | FGF18 | Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (335 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (250 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (357 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (593 aa) |
| | CSNK1A1 | Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (415 aa) |
| | RXRG | Retinoid X receptor gamma. (538 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (619 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa) |
| | AXIN1 | Axin 1. (992 aa) |
| | CTNNA1 | Catenin alpha 1. (918 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa) |
| | RB1 | RB transcriptional corepressor 1. (927 aa) |
| | CTNNA2 | Catenin alpha 2. (953 aa) |
| | RXRA | Retinoid X receptor alpha. (556 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa) |
| | ABCB1 | ATP binding cassette subfamily B member 1. (1321 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (331 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | RARB | Retinoic acid receptor beta. (464 aa) |
