STRINGSTRING
PDGFRB PDGFRB CHKB CHKB SLC44A4 SLC44A4 SLC22A2 SLC22A2 RAC2 RAC2 PIP5K1B PIP5K1B SLC5A7 SLC5A7 PRKCG PRKCG SLC44A1 SLC44A1 EGFR EGFR WASF1 WASF1 PIK3R3 PIK3R3 RAF1 RAF1 AKT2 AKT2 RAC3 RAC3 GPCPD1 GPCPD1 EIF4EBP1 EIF4EBP1 SOS1 SOS1 WASF3 WASF3 SP1 SP1 PIK3CB PIK3CB PIK3R1 PIK3R1 PDGFC PDGFC MAPK10 MAPK10 NRAS NRAS PLA2G4D PLA2G4D PLA2G4F PLA2G4F PRKCA PRKCA EGF EGF WASF2 WASF2 PIP5K1A PIP5K1A PLA2G4A PLA2G4A SOS2 SOS2 PIK3R2 PIK3R2 AKT3 AKT3 MTOR MTOR FOS FOS DGKE DGKE PRKCB PRKCB RPS6KB1 RPS6KB1 AKT1 AKT1 PIP5K1C PIP5K1C PLPP2 PLPP2 PIK3CD PIK3CD TSC1 TSC1 SLC44A5 SLC44A5 MAPK1 MAPK1 PCYT1A PCYT1A RPS6KB2 RPS6KB2 TSC2 TSC2 DGKB DGKB HRAS HRAS JMJD7 JMJD7 MAP2K2 MAP2K2 CHKA CHKA MAP2K1 MAP2K1 PLCG1 PLCG1 MAPK8 MAPK8 PIK3CA PIK3CA GRB2 GRB2 RHEB RHEB DGKH DGKH SLC44A3 SLC44A3 DGKA DGKA PDPK1 PDPK1 SLC22A1 SLC22A1 PDGFA PDGFA PDGFB PDGFB PLA2G4E PLA2G4E RALGDS RALGDS DGKG DGKG DGKI DGKI PLPP1 PLPP1 SLC44A2 SLC44A2 SLC22A3 SLC22A3 MAPK9 MAPK9 PCYT1B PCYT1B SLC22A4 SLC22A4 HIF1A HIF1A PDGFRA PDGFRA DGKD DGKD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] (1099 aa)
CHKBCholine kinase beta. (395 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (708 aa)
SLC22A2Solute carrier family 22 member 2. (533 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (578 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (723 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
WASF1WASP family member 1. (559 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
RAC3Uncharacterized protein. (210 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (683 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
WASF3WASP family member 3. (502 aa)
SP1Sp1 transcription factor. (782 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NRASUncharacterized protein. (189 aa)
PLA2G4DPhospholipase A2. (812 aa)
PLA2G4FPhospholipase A2. (870 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa)
WASF2WASP family member 2. (498 aa)
PIP5K1APIPK domain-containing protein. (562 aa)
PLA2G4APhospholipase A2. (749 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1375 aa)
PIK3R2Uncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
DGKEDiacylglycerol kinase. (564 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
PLPP2Phospholipid phosphatase 2. (545 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
TSC1TSC complex subunit 1. (1169 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (720 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (425 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (510 aa)
TSC2TSC complex subunit 2. (1783 aa)
DGKBDiacylglycerol kinase. (803 aa)
HRASUncharacterized protein. (189 aa)
JMJD7Phospholipase A2. (841 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
CHKACholine kinase alpha. (382 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
RHEBRas homolog, mTORC1 binding. (232 aa)
DGKHDiacylglycerol kinase. (1199 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (824 aa)
DGKADiacylglycerol kinase. (803 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
SLC22A1Uncharacterized protein. (177 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (423 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa)
PLA2G4EPhospholipase A2. (891 aa)
RALGDSUncharacterized protein. (1045 aa)
DGKGDiacylglycerol kinase. (790 aa)
DGKIDiacylglycerol kinase. (1210 aa)
PLPP1Phospholipid phosphatase 1. (284 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (836 aa)
SLC22A3Solute carrier family 22 member 3. (550 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
SLC22A4Solute carrier family 22 member 4. (784 aa)
HIF1AUncharacterized protein. (823 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa)
DGKDDiacylglycerol kinase. (1312 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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