STRINGSTRING
TICAM2 TICAM2 IFNGR1 IFNGR1 IFNG IFNG MAPK12 MAPK12 MAPK13 MAPK13 NFKBIE NFKBIE CD274 CD274 EGFR EGFR PIK3R3 PIK3R3 RAF1 RAF1 MYD88 MYD88 PRKCQ PRKCQ ALK ALK AKT2 AKT2 TRAF6 TRAF6 CSNK2A1 CSNK2A1 PIK3CB PIK3CB PIK3R1 PIK3R1 TLR2 TLR2 PTPN11 PTPN11 NRAS NRAS CHUK CHUK PPP3CA PPP3CA LCK LCK EGF EGF NFATC2 NFATC2 CD3G CD3G PDCD1 PDCD1 RELA RELA NFKBIA NFKBIA BATF2 BATF2 PIK3R2 PIK3R2 AKT3 AKT3 MTOR MTOR FOS FOS LAT LAT RPS6KB1 RPS6KB1 AKT1 AKT1 IKBKG IKBKG PIK3CD PIK3CD TIRAP TIRAP TLR9-2 TLR9-2 MAPK1 MAPK1 TLR4 TLR4 NFATC1 NFATC1 MAP3K3 MAP3K3 TICAM1 TICAM1 BATF3 BATF3 RPS6KB2 RPS6KB2 CD3D CD3D JAK1 JAK1 HRAS HRAS PPP3CC PPP3CC CD247 CD247 MAP2K2 MAP2K2 JAK2 JAK2 PPP3CB PPP3CB PTEN PTEN IFNGR2 IFNGR2 MAP2K1 MAP2K1 PLCG1 PLCG1 CSNK2A2 CSNK2A2 IKBKB IKBKB MAPK14 MAPK14 PIK3CA PIK3CA STAT1 STAT1 STAT3 STAT3 CD28 CD28 NFATC3 NFATC3 JDP2 JDP2 NFKB1 NFKB1 LOC487739 LOC487739 MAP2K6 MAP2K6 EML4 EML4 MAP2K3 MAP2K3 MAPK11 MAPK11 CD4 CD4 HIF1A HIF1A PPP3R1 PPP3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TICAM2TIR domain-containing protein. (238 aa)
IFNGR1Interferon gamma receptor 1. (475 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
MAPK12Mitogen-activated protein kinase. (366 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
NFKBIEANK_REP_REGION domain-containing protein. (267 aa)
CD274Programmed death ligand 1. (289 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
PIK3R3Uncharacterized protein. (461 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MYD88MYD88 innate immune signal transduction adaptor. (398 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
ALKTyrosine-protein kinase receptor. (1631 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
NRASUncharacterized protein. (189 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LCKTyrosine-protein kinase. (509 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1211 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
CD3GCD3g molecule. (182 aa)
PDCD1Programmed cell death 1. (288 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (272 aa)
PIK3R2Uncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LATLinker for activation of T cells. (290 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
TIRAPTIR domain containing adaptor protein. (406 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (626 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (337 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (510 aa)
CD3DCD3d molecule. (194 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
HRASUncharacterized protein. (189 aa)
PPP3CCSerine/threonine-protein phosphatase. (540 aa)
CD247Uncharacterized protein. (199 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). (442 aa)
JAK2Janus kinase 2. (1407 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
IFNGR2Uncharacterized protein. (435 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (478 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
CSNK2A2Casein kinase 2 alpha 2. (571 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
CD28CD28 molecule. (246 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
JDP2Jun dimerization protein 2. (358 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
LOC487739Uncharacterized protein. (363 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
EML4EMAP like 4. (1006 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (517 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
HIF1AUncharacterized protein. (823 aa)
PPP3R1Uncharacterized protein. (169 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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