STRINGSTRING
IFNG IFNG TNF TNF C2 C2 HLA-DQB2 HLA-DQB2 HLA-DQB1 HLA-DQB1 DLA-DOA DLA-DOA C5 C5 ACTN4 ACTN4 TRIM21 TRIM21 H2BC1 H2BC1 H2AFZ H2AFZ CD80 CD80 IL10 IL10 FCGR1A FCGR1A H2AC21 H2AC21 CD86 CD86 H2AJ H2AJ SNRPD3 SNRPD3 MACROH2A2 MACROH2A2 C1R C1R C1QC C1QC H2BFWT H2BFWT SNRPD1 SNRPD1 C6 C6 C7 C7 C3 C3 C9 C9 C8B C8B CD40LG CD40LG GRIN2A GRIN2A SNRPB SNRPB H2AX H2AX H2AC1 H2AC1 H2AW H2AW LOC482202 LOC482202 SSB SSB LOC106558252 LOC106558252 LOC478743 LOC478743 LOC480110 LOC480110 H2BC21 H2BC21 J9P0B2_CANLF J9P0B2_CANLF LOC483168 LOC483168 C1QB C1QB LOC611231 LOC611231 GRIN2B GRIN2B H2BC18 H2BC18 LOC612779 LOC612779 C1QA C1QA LOC488289 LOC488289 H2AC6 H2AC6 LOC488297 LOC488297 LOC488290 LOC488290 LOC111090006 LOC111090006 LOC481722 LOC481722 CTSG CTSG LOC488263 LOC488263 C1S C1S LOC488264 LOC488264 DLA-DRA DLA-DRA ENSCAFP00000046288 ENSCAFP00000046288 ACTN1 ACTN1 C8A C8A RO60 RO60 H2BC10 H2BC10 CD28 CD28 LOC478984 LOC478984 H2AZ2 H2AZ2 ENSCAFP00000060899 ENSCAFP00000060899 CD40 CD40 LOC488304 LOC488304 ENSCAFP00000064407 ENSCAFP00000064407
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
C2Complement C2; Belongs to the peptidase S1 family. (780 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (205 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
DLA-DOAMHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa)
C5Complement C5. (1611 aa)
ACTN4Actinin alpha 4. (1163 aa)
TRIM21Tripartite motif containing 21. (469 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (179 aa)
CD80CD80 molecule. (304 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
FCGR1AUncharacterized protein. (428 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
CD86CD86 molecule. (329 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (719 aa)
C1QCComplement C1q C chain. (235 aa)
H2BFWTHistone domain-containing protein; Belongs to the histone H2B family. (150 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
C6Complement C6. (956 aa)
C7Complement C7. (892 aa)
C3Complement C3. (1566 aa)
C9Complement C9. (568 aa)
C8BComplement C8 beta chain. (590 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (231 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
LOC482202Histone H2B; Belongs to the histone H2B family. (126 aa)
SSBSmall RNA binding exonuclease protection factor La. (406 aa)
LOC106558252Histone H2A; Belongs to the histone H2A family. (204 aa)
LOC478743Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC480110Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
J9P0B2_CANLFHistone domain-containing protein; Belongs to the histone H2B family. (277 aa)
LOC483168Histone H2A; Belongs to the histone H2A family. (130 aa)
C1QBComplement C1q B chain. (250 aa)
LOC611231Histone H2A; Belongs to the histone H2A family. (128 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator fo [...] (1485 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (135 aa)
LOC612779Histone H3; Belongs to the histone H3 family. (136 aa)
C1QAComplement C1q A chain. (264 aa)
LOC488289Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC488297Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC488290Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111090006Histone H3; Belongs to the histone H3 family. (136 aa)
LOC481722Uncharacterized protein. (1738 aa)
CTSGGranzyme B; Belongs to the peptidase S1 family. (351 aa)
LOC488263Histone H3; Belongs to the histone H3 family. (136 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (696 aa)
LOC488264Histone H2B; Belongs to the histone H2B family. (435 aa)
DLA-DRAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
ENSCAFP00000046288Histone H2B; Belongs to the histone H2B family. (177 aa)
ACTN1Actinin alpha 1. (956 aa)
C8AComplement C8 alpha chain. (608 aa)
RO60Ro60, Y RNA binding protein. (557 aa)
H2BC10Histone H2B; Belongs to the histone H2B family. (126 aa)
CD28CD28 molecule. (246 aa)
LOC478984Uncharacterized protein. (286 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (167 aa)
ENSCAFP00000060899Histone H2A; Belongs to the histone H2A family. (130 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (355 aa)
LOC488304Histone H2A; Belongs to the histone H2A family. (119 aa)
ENSCAFP00000064407Histone H2B; Belongs to the histone H2B family. (118 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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