STRINGSTRING
ACCS ACCS ARG2 ARG2 PHYKPL PHYKPL EIF5A2 EIF5A2 PYROXD1 PYROXD1 ODC1 ODC1 PSAT1 PSAT1 LOC112908249 LOC112908249 MAT2A MAT2A RIMKLA RIMKLA LOC112926758 LOC112926758 CARNMT1 CARNMT1 ALDH5A1 ALDH5A1 OAZ1 OAZ1 AHCYL1 AHCYL1 DOHH DOHH MAT2B MAT2B LOC112921034 LOC112921034 AHCY AHCY MTHFD2 MTHFD2 GADL1 GADL1 ENSVVUP00000006944 ENSVVUP00000006944 MTHFD1L MTHFD1L OAT OAT ALAS2 ALAS2 DDO DDO AMD1 AMD1 APIP APIP HYKK HYKK SDSL SDSL SDS SDS CTH CTH MTAP MTAP DAO DAO ADI1 ADI1 ADO ADO CPS1 CPS1 FOLH1 FOLH1 ARG1 ARG1 MTR MTR FADS6 FADS6 THNSL1 THNSL1 CARNS1 CARNS1 RIMKLB RIMKLB ENSVVUP00000014749 ENSVVUP00000014749 RIDA RIDA OTC OTC GCAT-2 GCAT-2 AHCYL2 AHCYL2 AGA AGA SELENBP1 SELENBP1 ASPDH ASPDH SMS SMS OAZ3 OAZ3 FPGS FPGS ENSVVUP00000019218 ENSVVUP00000019218 LOC112922441 LOC112922441 ENSVVUP00000019927 ENSVVUP00000019927 LOC112920667 LOC112920667 AZIN2 AZIN2 GAD1 GAD1 ASNS ASNS NOS2 NOS2 CAD CAD PEPD PEPD ASL ASL PSPH PSPH UBASH3A UBASH3A AZIN1 AZIN1 DHFR-2 DHFR-2 AADAT AADAT DPYS DPYS CBS CBS ABAT ABAT LOC112919196 LOC112919196 NAGS NAGS TAT TAT SHMT2 SHMT2 ACOD1 ACOD1 GGH GGH LOC112910728 LOC112910728 CNDP2 CNDP2 CNDP1 CNDP1 VNN1 VNN1 LOC112919381 LOC112919381 UPB1 UPB1 MIF MIF ENSVVUP00000026647 ENSVVUP00000026647 CDO1 CDO1 ENSVVUP00000026891 ENSVVUP00000026891 PIPOX PIPOX IL4I1 IL4I1 GLDC GLDC ILVBL ILVBL ALDH1L1 ALDH1L1 AIFM3 AIFM3 GLS2 GLS2 AIFM2 AIFM2 NIT2 NIT2 SRR SRR ALDH18A1 ALDH18A1 ALDH1L2 ALDH1L2 GART GART BCAT2 BCAT2 NAT8L NAT8L DHPS DHPS FTCD FTCD ENSVVUP00000033287 ENSVVUP00000033287 SMOX SMOX ENOPH1 ENOPH1 DHFR DHFR DMGDH DMGDH BHMT2 BHMT2 BHMT BHMT ENSVVUP00000034957 ENSVVUP00000034957 ENSVVUP00000035068 ENSVVUP00000035068 ASPA ASPA MAT1A MAT1A ENSVVUP00000036013 ENSVVUP00000036013 GLUD1 GLUD1 MRI1 MRI1 ALAS1 ALAS1 LOC112910690 LOC112910690 SRM SRM GCSH GCSH GLS GLS ASNSD1 ASNSD1 SARDH SARDH ENSVVUP00000038628 ENSVVUP00000038628 GNMT GNMT ASS1 ASS1 EIF5A EIF5A MTHFD1 MTHFD1 ENSVVUP00000039949 ENSVVUP00000039949 MTHFR MTHFR THNSL2 THNSL2 AGMAT AGMAT AMT AMT ENSVVUP00000041792 ENSVVUP00000041792 L2HGDH L2HGDH ASRGL1 ASRGL1 SHMT1 SHMT1 BCAT1 BCAT1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ACCS1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2. (504 aa)
ARG2Arginase. (354 aa)
PHYKPL5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (476 aa)
EIF5A2Eukaryotic translation initiation factor 5A. (167 aa)
PYROXD1Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 isoform X1. (502 aa)
ODC1Ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
PSAT1Phosphoserine aminotransferase. (406 aa)
LOC112908249Amine oxidase. (525 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (413 aa)
RIMKLAN-acetylaspartylglutamate synthase A. (391 aa)
LOC112926758L-threonine 3-dehydrogenase, mitochondrial. (373 aa)
CARNMT1Carnosine N-methyltransferase isoform X1. (411 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (405 aa)
OAZ1LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 1. (218 aa)
AHCYL1Adenosylhomocysteinase. (556 aa)
DOHHDeoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (303 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (375 aa)
LOC1129210345-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (239 aa)
AHCYAdenosylhomocysteinase. (421 aa)
MTHFD2Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial. (441 aa)
GADL1Acidic amino acid decarboxylase GADL1 isoform X1. (521 aa)
ENSVVUP00000006944annotation not available (109 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. (728 aa)
OATOrnithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa)
ALAS25-aminolevulinate synthase. (562 aa)
DDOD-aspartate oxidase. (309 aa)
AMD1S-adenosylmethionine decarboxylase proenzyme. (334 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (416 aa)
HYKKHydroxylysine kinase isoform X2. (377 aa)
SDSLSerine dehydratase-like. (336 aa)
SDSL-serine dehydratase/L-threonine deaminase isoform X1. (378 aa)
CTHCystathionine gamma-lyase. (372 aa)
MTAPS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (482 aa)
DAOD-amino-acid oxidase. (347 aa)
ADI11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (179 aa)
ADO2-aminoethanethiol dioxygenase. (270 aa)
CPS1Carbamoyl-phosphate synthase [ammonia], mitochondrial. (1500 aa)
FOLH1Glutamate carboxypeptidase 2 isoform X1. (751 aa)
ARG1Arginase. (322 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1269 aa)
FADS6Fatty acid desaturase 6. (342 aa)
THNSL1Threonine synthase-like 1. (743 aa)
CARNS1Carnosine synthase 1. (962 aa)
RIMKLBBeta-citrylglutamate synthase B isoform X1. (471 aa)
ENSVVUP00000014749annotation not available (85 aa)
RIDA2-iminobutanoate/2-iminopropanoate deaminase isoform X2. (137 aa)
OTCOrnithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
GCAT-22-amino-3-ketobutyrate coenzyme A ligase, mitochondrial. (290 aa)
AHCYL2Adenosylhomocysteinase. (610 aa)
AGAN(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase. (250 aa)
SELENBP1Methanethiol oxidase. (472 aa)
ASPDHPutative L-aspartate dehydrogenase isoform X2. (287 aa)
SMSSpermine synthase. (395 aa)
OAZ3LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 3. (240 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (588 aa)
ENSVVUP00000019218annotation not available (161 aa)
LOC112922441LOW QUALITY PROTEIN: C-1-tetrahydrofolate synthase, cytoplasmic-like. (792 aa)
ENSVVUP00000019927annotation not available (160 aa)
LOC112920667Probable low-specificity L-threonine aldolase 2. (500 aa)
AZIN2Antizyme inhibitor 2 isoform X2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (493 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
CADCAD protein isoform X1. (2242 aa)
PEPDxaa-Pro dipeptidase. (715 aa)
ASLArgininosuccinate lyase. (587 aa)
PSPHPhosphoserine phosphatase. (280 aa)
UBASH3AUbiquitin-associated and SH3 domain-containing protein A isoform X1. (643 aa)
AZIN1Antizyme inhibitor 1 isoform X1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (447 aa)
DHFR-2Dihydrofolate reductase isoform X3. (182 aa)
AADATKynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X2. (424 aa)
DPYSDihydropyrimidinase. (518 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (564 aa)
ABAT4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
LOC112919196Glutamate decarboxylase 1-like. (542 aa)
NAGSN-acetylglutamate synthase, mitochondrial. (386 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (505 aa)
ACOD1Cis-aconitate decarboxylase. (482 aa)
GGHFolate gamma-glutamyl hydrolase. (318 aa)
LOC112910728LOW QUALITY PROTEIN: glutamate dehydrogenase 1, mitochondrial-like; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (246 aa)
CNDP2Cytosolic non-specific dipeptidase. (473 aa)
CNDP1beta-Ala-His dipeptidase isoform X1. (484 aa)
VNN1Pantetheinase isoform X3. (514 aa)
LOC112919381Vascular non-inflammatory molecule 3-like. (207 aa)
UPB1Beta-ureidopropionase. (393 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
ENSVVUP00000026647annotation not available (129 aa)
CDO1Cysteine dioxygenase. (200 aa)
ENSVVUP00000026891LOW QUALITY PROTEIN: spermine synthase-like. (262 aa)
PIPOXPeroxisomal sarcosine oxidase isoform X1. (392 aa)
IL4I1L-amino-acid oxidase. (574 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1054 aa)
ILVBLAcetolactate synthase-like protein; Belongs to the TPP enzyme family. (785 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
AIFM3Apoptosis-inducing factor 3 isoform X2. (598 aa)
GLS2Glutaminase liver isoform, mitochondrial isoform X2. (602 aa)
AIFM2Apoptosis-inducing factor 2. (373 aa)
NIT2Omega-amidase NIT2. (412 aa)
SRRSerine racemase isoform X6. (339 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (921 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
BCAT2Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (434 aa)
NAT8LN-acetylaspartate synthetase. (292 aa)
DHPSDeoxyhypusine synthase isoform X1. (369 aa)
FTCDFormimidoyltransferase cyclodeaminase. (449 aa)
ENSVVUP00000033287annotation not available (268 aa)
SMOXSpermine oxidase isoform X2. (555 aa)
ENOPH1Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa)
DHFRDihydrofolate reductase isoform X2. (182 aa)
DMGDHDimethylglycine dehydrogenase, mitochondrial. (855 aa)
BHMT2Betaine--homocysteine S-methyltransferase 1. (415 aa)
BHMTBetaine--homocysteine S-methyltransferase 1. (279 aa)
ENSVVUP00000034957annotation not available (94 aa)
ENSVVUP00000035068annotation not available (214 aa)
ASPAAspartoacylase isoform X1. (313 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
ENSVVUP00000036013annotation not available (373 aa)
GLUD1Glutamate dehydrogenase 1, mitochondrial. (173 aa)
MRI1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (394 aa)
ALAS15-aminolevulinate synthase. (699 aa)
LOC112910690Aminoacylase-1 isoform X1. (408 aa)
SRMSpermidine synthase; Belongs to the spermidine/spermine synthase family. (302 aa)
GCSHGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (151 aa)
GLSGlutaminase kidney isoform, mitochondrial. (599 aa)
ASNSD1Asparagine synthetase domain-containing protein 1. (558 aa)
SARDHLOW QUALITY PROTEIN: sarcosine dehydrogenase, mitochondrial. (907 aa)
ENSVVUP00000038628annotation not available (69 aa)
GNMTGlycine N-methyltransferase. (295 aa)
ASS1Argininosuccinate synthase. (445 aa)
EIF5AEukaryotic translation initiation factor 5A. (193 aa)
MTHFD1C-1-tetrahydrofolate synthase, cytoplasmic. (496 aa)
ENSVVUP00000039949annotation not available (162 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
THNSL2Threonine synthase-like 2 isoform X1. (484 aa)
AGMATAgmatinase, mitochondrial; Belongs to the arginase family. (352 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
ENSVVUP00000041792annotation not available (153 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1. (463 aa)
ASRGL1Isoaspartyl peptidase/L-asparaginase. (312 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (486 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (381 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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