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| | SIRT7 | NAD-dependent protein deacetylase sirtuin-7. (475 aa) |
| | PDE7B | Phosphodiesterase. (508 aa) |
| | HDDC2 | HD domain-containing protein 2. (215 aa) |
| | BTD | Biotinidase isoform X1. (532 aa) |
| | PDE10A | Phosphodiesterase. (794 aa) |
| | RRM2 | Ribonucleoside-diphosphate reductase subunit M2. (381 aa) |
| | GUCA2A | Guanylin. (111 aa) |
| | GUCA2B | Guanylate cyclase activator 2B. (124 aa) |
| | ADAT3 | LOW QUALITY PROTEIN: probable inactive tRNA-specific adenosine deaminase-like protein 3. (386 aa) |
| | NMRK1 | Nicotinamide riboside kinase 1 isoform X1. (227 aa) |
| | A1CF | APOBEC1 complementation factor isoform X2. (582 aa) |
| | TMEM179 | Transmembrane protein 179 isoform X1. (233 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (1068 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (932 aa) |
| | TPMT | Thiopurine S-methyltransferase. (245 aa) |
| | ADSS1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (476 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | NADSYN1 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (687 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (482 aa) |
| | PRKG1 | cGMP-dependent protein kinase. (568 aa) |
| | NT5C2 | Cytosolic purine 5'-nucleotidase isoform X1. (569 aa) |
| | TYMS | Thymidylate synthase isoform X1. (314 aa) |
| | GUCY2C | Guanylate cyclase. (1072 aa) |
| | LOC112928185 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (266 aa) |
| | NADK | NAD kinase isoform X1. (497 aa) |
| | ADAT2 | tRNA-specific adenosine deaminase 2. (192 aa) |
| | CFAP74 | Cilia- and flagella-associated protein 74 isoform X5. (1559 aa) |
| | DGUOK | Deoxyguanosine kinase, mitochondrial isoform X1. (375 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4 isoform X1; Belongs to the GDA1/CD39 NTPase family. (616 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (648 aa) |
| | NT5C1A | Cytosolic 5'-nucleotidase 1A. (365 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | LOC112923709 | Uncharacterized protein LOC112923709 isoform X1. (964 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (532 aa) |
| | AK9 | Adenylate kinase 9 isoform X2. (1989 aa) |
| | RNPEP | Aminopeptidase B isoform X2. (587 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (294 aa) |
| | HDDC3 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase MESH1. (217 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (412 aa) |
| | ANKLE2 | Ankyrin repeat and LEM domain-containing protein 2. (917 aa) |
| | TK2 | Thymidine kinase 2, mitochondrial. (232 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (490 aa) |
| | AK3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa) |
| | NTPCR | Cancer-related nucleoside-triphosphatase isoform X2. (190 aa) |
| | ENSVVUP00000010019 | annotation not available (137 aa) |
| | XDH | Xanthine dehydrogenase/oxidase. (1333 aa) |
| | PDE4C | Phosphodiesterase. (725 aa) |
| | PDE5A | Phosphodiesterase. (865 aa) |
| | CMPK2 | UMP-CMP kinase 2, mitochondrial. (57 aa) |
| | KIAA1614 | Uncharacterized protein KIAA1614 homolog. (1038 aa) |
| | NMNAT2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2. (308 aa) |
| | ATIC | Bifunctional purine biosynthesis protein PURH. (533 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (288 aa) |
| | APOBEC4 | Putative C->U-editing enzyme APOBEC-4. (368 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (856 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (755 aa) |
| | LOC112927879 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa) |
| | PDE11A | Phosphodiesterase. (919 aa) |
| | UCK2 | Uridine-cytidine kinase 2. (262 aa) |
| | UPP1 | Uridine phosphorylase 1. (369 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (487 aa) |
| | ENSVVUP00000014155 | annotation not available (85 aa) |
| | APOBEC1 | C->U-editing enzyme APOBEC-1. (236 aa) |
| | GUCY2F | Guanylate cyclase. (169 aa) |
| | SPAG17 | Sperm-associated antigen 17. (2041 aa) |
| | NADK2 | NAD kinase 2, mitochondrial isoform X1. (448 aa) |
| | NT5C | 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1. (112 aa) |
| | DCTD | Deoxycytidylate deaminase isoform X2. (322 aa) |
| | ENSVVUP00000016957 | annotation not available (226 aa) |
| | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B isoform X1. (351 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | NUDT12 | Peroxisomal NADH pyrophosphatase NUDT12 isoform X1. (627 aa) |
| | NME4 | Nucleoside diphosphate kinase. (183 aa) |
| | ENSVVUP00000018567 | annotation not available (227 aa) |
| | HPRT1 | Hypoxanthine-guanine phosphoribosyltransferase. (216 aa) |
| | GUCY1A2 | Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (694 aa) |
| | ENSVVUP00000019005 | annotation not available (185 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial isoform X3; Belongs to the adenylate kinase family. (171 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa) |
| | DUT | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1. (216 aa) |
| | CORO2B | Coronin; Belongs to the WD repeat coronin family. (475 aa) |
| | NT5C1B | Cytosolic 5'-nucleotidase 1B. (615 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (397 aa) |
| | SIRT3 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa) |
| | TK1 | Thymidine kinase. (289 aa) |
| | BST1 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2. (306 aa) |
| | CD38 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. (308 aa) |
| | ENSVVUP00000021003 | annotation not available (219 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (234 aa) |
| | LOC112926001 | Nicotinamide N-methyltransferase-like isoform X1. (264 aa) |
| | NNMT | Nicotinamide N-methyltransferase. (264 aa) |
| | TPK1 | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (244 aa) |
| | PDE1A | Phosphodiesterase. (533 aa) |
| | PDE9A | Phosphodiesterase. (534 aa) |
| | PPA2 | Inorganic pyrophosphatase 2, mitochondrial. (274 aa) |
| | PDE4A | Phosphodiesterase. (1017 aa) |
| | CFAP221 | Cilia- and flagella-associated protein 221. (906 aa) |
| | PDE7A | Phosphodiesterase. (483 aa) |
| | FAM181A | Protein FAM181A. (336 aa) |
| | MPP4 | MAGUK p55 subfamily member 4; Belongs to the MAGUK family. (622 aa) |
| | NT5C3B | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (383 aa) |
| | ADA | Adenosine deaminase isoform X1. (397 aa) |
| | LOC112932420 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (224 aa) |
| | NT5E | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (569 aa) |
| | GMPS | GMP synthase [glutamine-hydrolyzing]. (698 aa) |
| | SIRT4 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (313 aa) |
| | NUDT2 | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. (147 aa) |
| | PDE1C | Phosphodiesterase. (709 aa) |
| | TMIGD1 | Transmembrane and immunoglobulin domain-containing protein 1. (261 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa) |
| | PDE4D | Phosphodiesterase. (679 aa) |
| | GLRX | Glutaredoxin-1. (106 aa) |
| | NPR2 | Guanylate cyclase. (1047 aa) |
| | NAMPT | Nicotinamide phosphoribosyltransferase. (535 aa) |
| | NPR3 | Atrial natriuretic peptide receptor 3 isoform X2. (534 aa) |
| | ADA2 | Adenosine deaminase 2. (901 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6 isoform X2; Belongs to the GDA1/CD39 NTPase family. (476 aa) |
| | NAPRT | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (633 aa) |
| | MROH6 | LOW QUALITY PROTEIN: maestro heat-like repeat-containing protein family member 6. (646 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1 isoform X1; Belongs to the GDA1/CD39 NTPase family. (509 aa) |
| | MYCBP | c-Myc-binding protein. (103 aa) |
| | MANEAL | Glycoprotein endo-alpha-1,2-mannosidase-like protein. (263 aa) |
| | NMNAT1 | Nicotinamide-nucleotide adenylyltransferase. (279 aa) |
| | ADK | Adenosine kinase isoform X1. (421 aa) |
| | PDE1B | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1; Belongs to the cyclic nucleotide phosphodiesterase family. (583 aa) |
| | LOC112910844 | Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (719 aa) |
| | ADAT1 | tRNA-specific adenosine deaminase 1. (507 aa) |
| | UPRT | Uracil phosphoribosyltransferase homolog isoform X1. (305 aa) |
| | PRKG2 | cGMP-dependent protein kinase. (762 aa) |
| | PDE2A | Phosphodiesterase. (929 aa) |
| | GUCY1B1 | Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (641 aa) |
| | GUCY1A1 | Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (348 aa) |
| | NNT | NAD(P) transhydrogenase, mitochondrial isoform X1. (1114 aa) |
| | HLCS | Biotin--protein ligase isoform X2. (725 aa) |
| | NPPC | C-type natriuretic peptide. (126 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (753 aa) |
| | LOC112910958 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (213 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | NME7 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. (379 aa) |
| | ADCY10 | Adenylate cyclase type 10. (1610 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa) |
| | NMNAT3 | Nicotinamide-nucleotide adenylyltransferase. (273 aa) |
| | APOBEC2 | C->U-editing enzyme APOBEC-2. (224 aa) |
| | LOC112911845 | Adenylate kinase isoenzyme 1-like; Belongs to the adenylate kinase family. (223 aa) |
| | CCDC189 | Coiled-coil domain-containing protein 189. (329 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase isoform X1. (1338 aa) |
| | NPR1 | Guanylate cyclase. (1152 aa) |
| | AK7 | Adenylate kinase 7. (676 aa) |
| | UCK1 | Uridine-cytidine kinase 1. (263 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | NPPA | Natriuretic peptides A. (187 aa) |
| | NPPB | Natriuretic peptides B. (149 aa) |
| | THTPA | Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (387 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | NME6 | Nucleoside diphosphate kinase. (198 aa) |
| | NT5M | 5'(3')-deoxyribonucleotidase, mitochondrial isoform X2. (187 aa) |
