(85 nodes) Mixed, incl. RAB geranylgeranylation, and Rab-GAP-TBC domain network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBC1D14	TBC1 domain family member 14 isoform X1. (693 aa)
	RAB24	Ras-related protein Rab-24 isoform X1. (203 aa)
	RAB5A	Ras-related protein Rab-5A. (215 aa)
	RUFY1	RUN and FYVE domain-containing protein 1. (600 aa)
	RAB17	Ras-related protein Rab-17. (353 aa)
	RAB18	Ras-related protein Rab-18. (206 aa)
	VPS39	vam6/Vps39-like protein isoform X1. (886 aa)
	PTAR1	Protein prenyltransferase alpha subunit repeat-containing protein 1. (459 aa)
	VIPAS39	Spermatogenesis-defective protein 39 homolog. (502 aa)
	RAB32	Ras-related protein Rab-32. (365 aa)
	VPS41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (858 aa)
	RAB4B	Ras-related protein Rab-4B isoform X1. (213 aa)
	RAB6B	Ras-related protein Rab-6B. (208 aa)
	RAB3GAP1	Rab3 GTPase-activating protein catalytic subunit isoform X2. (1062 aa)
	VPS33B	Vacuolar protein sorting-associated protein 33B isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (737 aa)
	RAB4A	Ras-related protein Rab-4A. (231 aa)
	GDI2	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (423 aa)
	EHD3	EH domain-containing protein 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (547 aa)
	VPS45	Vacuolar protein sorting-associated protein 45 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (559 aa)
	ANKFY1	Rabankyrin-5. (1096 aa)
	TBC1D20	TBC1 domain family member 20. (351 aa)
	ENSVVUP00000011607	annotation not available (91 aa)
	TBC1D15	TBC1 domain family member 15 isoform X1. (691 aa)
	RAB33A	Ras-related protein Rab-33A. (237 aa)
	RAB26	Ras-related protein Rab-26 isoform X3. (190 aa)
	RAB2B	Ras-related protein Rab-2B isoform X2. (245 aa)
	RABGAP1	Rab GTPase-activating protein 1 isoform X1. (1069 aa)
	TBC1D8B	TBC1 domain family member 8B isoform X1. (1120 aa)
	ENSVVUP00000013257	annotation not available (131 aa)
	GAPVD1	GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3. (1350 aa)
	TBC1D10C	Carabin. (446 aa)
	PDZD8	PDZ domain-containing protein 8. (1162 aa)
	DENND10	Protein FAM45A isoform X1. (642 aa)
	ENSVVUP00000015581	annotation not available (210 aa)
	RAB31	Ras-related protein Rab-31. (195 aa)
	CHM	Rab proteins geranylgeranyltransferase component A 1 isoform X1. (688 aa)
	RAB14	Ras-related protein Rab-14. (228 aa)
	VPS8	Vacuolar protein sorting-associated protein 8 homolog isoform X2. (1426 aa)
	TGFBRAP1	Transforming growth factor-beta receptor-associated protein 1. (906 aa)
	RAB3GAP2	Rab3 GTPase-activating protein non-catalytic subunit isoform X2. (1394 aa)
	TUFT1	Tuftelin. (284 aa)
	RAB7B	Ras-related protein Rab-7b isoform X1. (200 aa)
	RBSN	Rabenosyn-5. (782 aa)
	TBC1D19	TBC1 domain family member 19. (452 aa)
	PTP4A2	Protein tyrosine phosphatase type IVA 2. (167 aa)
	CCZ1	Vacuolar fusion protein CCZ1 homolog isoform X1. (583 aa)
	GORASP2	Golgi reassembly-stacking protein 2. (444 aa)
	LOC112934124	Rab5 GDP/GTP exchange factor isoform X1. (800 aa)
	RAB22A	Ras-related protein Rab-22A. (215 aa)
	TBC1D25	TBC1 domain family member 25 isoform X2. (763 aa)
	VPS33A	Vacuolar protein sorting-associated protein 33A; Belongs to the STXBP/unc-18/SEC1 family. (611 aa)
	TBC1D16	TBC1 domain family member 16 isoform X3. (763 aa)
	RAB7A	Ras-related protein Rab-7a. (207 aa)
	TBC1D21	TBC1 domain family member 21 isoform X1. (499 aa)
	RAB36	Ras-related protein Rab-36. (485 aa)
	RAB20	Ras-related protein Rab-20. (235 aa)
	TBC1D17	TBC1 domain family member 17. (442 aa)
	ENSVVUP00000028288	annotation not available (81 aa)
	EVI5	Ecotropic viral integration site 5 protein homolog isoform X1. (882 aa)
	RAB5C	Ras-related protein Rab-5C. (242 aa)
	AVL9	Late secretory pathway protein AVL9 homolog. (620 aa)
	RAB33B	Ras-related protein Rab-33B. (225 aa)
	RAB5B	Ras-related protein Rab-5B. (273 aa)
	RABL3	Rab-like protein 3 isoform X1. (274 aa)
	ZFYVE27	Protrudin isoform X2. (446 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
	RAB6A	Ras-related protein Rab-6A isoform X1. (208 aa)
	VPS16	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
	TBC1D13	TBC1 domain family member 13. (393 aa)
	RABL6	Rab-like protein 6 isoform X1. (757 aa)
	TBC1D10B	TBC1 domain family member 10B. (806 aa)
	BLZF1	Golgin-45. (402 aa)
	TBC1D22B	TBC1 domain family member 22B. (523 aa)
	VPS18	Vacuolar protein sorting-associated protein 18 homolog. (973 aa)
	RAB1B	Ras-related protein Rab-1B. (218 aa)
	LOC112924761	Rabankyrin-5-like isoform X1. (331 aa)
	MON1B	Vacuolar fusion protein MON1 homolog B. (574 aa)
	RABEP1	Rab GTPase-binding effector protein 1. (866 aa)
	EHD1	EH domain-containing protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (635 aa)
	RAB1A	Ras-related protein Rab-1A. (205 aa)
	DENND11	Protein LCHN. (518 aa)
	MON1A	Vacuolar fusion protein MON1 homolog A. (555 aa)
	TBC1D8	TBC1 domain family member 8. (1115 aa)
	GDI1	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (425 aa)
	RABGGTB	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (412 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKFY1	EHD1	ENSVVUP00000011060	ENSVVUP00000038646	Rabankyrin-5.	EH domain-containing protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.459
ANKFY1	EHD3	ENSVVUP00000011060	ENSVVUP00000010260	Rabankyrin-5.	EH domain-containing protein 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.459
ANKFY1	GAPVD1	ENSVVUP00000011060	ENSVVUP00000013748	Rabankyrin-5.	GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3.	0.647
ANKFY1	GDI1	ENSVVUP00000011060	ENSVVUP00000041520	Rabankyrin-5.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.438
ANKFY1	LOC112924761	ENSVVUP00000011060	ENSVVUP00000038128	Rabankyrin-5.	Rabankyrin-5-like isoform X1.	0.711
ANKFY1	LOC112934124	ENSVVUP00000011060	ENSVVUP00000022473	Rabankyrin-5.	Rab5 GDP/GTP exchange factor isoform X1.	0.438
ANKFY1	RAB17	ENSVVUP00000011060	ENSVVUP00000002010	Rabankyrin-5.	Ras-related protein Rab-17.	0.610
ANKFY1	RAB20	ENSVVUP00000011060	ENSVVUP00000027184	Rabankyrin-5.	Ras-related protein Rab-20.	0.573
ANKFY1	RAB22A	ENSVVUP00000011060	ENSVVUP00000023356	Rabankyrin-5.	Ras-related protein Rab-22A.	0.573
ANKFY1	RAB24	ENSVVUP00000011060	ENSVVUP00000000236	Rabankyrin-5.	Ras-related protein Rab-24 isoform X1.	0.573
ANKFY1	RAB31	ENSVVUP00000011060	ENSVVUP00000016120	Rabankyrin-5.	Ras-related protein Rab-31.	0.711
ANKFY1	RAB5A	ENSVVUP00000011060	ENSVVUP00000000519	Rabankyrin-5.	Ras-related protein Rab-5A.	0.610
ANKFY1	RAB5B	ENSVVUP00000011060	ENSVVUP00000030294	Rabankyrin-5.	Ras-related protein Rab-5B.	0.723
ANKFY1	RAB5C	ENSVVUP00000011060	ENSVVUP00000028926	Rabankyrin-5.	Ras-related protein Rab-5C.	0.723
ANKFY1	RABEP1	ENSVVUP00000011060	ENSVVUP00000038467	Rabankyrin-5.	Rab GTPase-binding effector protein 1.	0.481
ANKFY1	RBSN	ENSVVUP00000011060	ENSVVUP00000018826	Rabankyrin-5.	Rabenosyn-5.	0.624
ANKFY1	TBC1D8B	ENSVVUP00000011060	ENSVVUP00000013119	Rabankyrin-5.	TBC1 domain family member 8B isoform X1.	0.770
ANKFY1	VPS8	ENSVVUP00000011060	ENSVVUP00000016716	Rabankyrin-5.	Vacuolar protein sorting-associated protein 8 homolog isoform X2.	0.534
AVL9	CCZ1	ENSVVUP00000029177	ENSVVUP00000020560	Late secretory pathway protein AVL9 homolog.	Vacuolar fusion protein CCZ1 homolog isoform X1.	0.453
AVL9	DENND10	ENSVVUP00000029177	ENSVVUP00000014862	Late secretory pathway protein AVL9 homolog.	Protein FAM45A isoform X1.	0.769