(37 nodes) Endosomal Sorting Complex Required For Transport (ESCRT) network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHMP4C	Charged multivesicular body protein 4c. (236 aa)
	ENSVVUP00000002781	annotation not available (372 aa)
	TSG101	LOW QUALITY PROTEIN: tumor susceptibility gene 101 protein. (373 aa)
	CHMP2A	Charged multivesicular body protein 2a isoform X2. (222 aa)
	PTPN23	Tyrosine-protein phosphatase non-receptor type 23. (1646 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	CHMP1A	Charged multivesicular body protein 1a. (210 aa)
	STAM	Signal transducing adapter molecule 1 isoform X1. (538 aa)
	VTA1	Vacuolar protein sorting-associated protein VTA1 homolog isoform X1. (306 aa)
	CHMP4B	Charged multivesicular body protein 4b. (224 aa)
	VPS37C	Vacuolar protein sorting-associated protein 37C isoform X1. (379 aa)
	CHMP7	Charged multivesicular body protein 7. (450 aa)
	VPS28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (221 aa)
	VPS37A	Vacuolar protein sorting-associated protein 37A isoform X1. (396 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (540 aa)
	MVB12B	Multivesicular body subunit 12B isoform X2. (306 aa)
	STAM2	Signal transducing adapter molecule 2 isoform X1. (581 aa)
	MVB12A	Multivesicular body subunit 12A isoform X1. (298 aa)
	VPS4A	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (518 aa)
	IST1	IST1 homolog isoform X1. (366 aa)
	VPS4B	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (461 aa)
	CHMP6	Charged multivesicular body protein 6. (184 aa)
	CHMP2B	Charged multivesicular body protein 2b. (221 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (716 aa)
	UBAP1	LOW QUALITY PROTEIN: ubiquitin-associated protein 1. (466 aa)
	CHMP5	Charged multivesicular body protein 5. (288 aa)
	PDCD6IP	Programmed cell death 6-interacting protein isoform X2. (869 aa)
	VPS25	Vacuolar protein-sorting-associated protein 25. (176 aa)
	VPS37D	Vacuolar protein sorting-associated protein 37D. (266 aa)
	ENSVVUP00000034315	annotation not available (59 aa)
	ENSVVUP00000036810	annotation not available (68 aa)
	ZFYVE19	abscission/NoCut checkpoint regulator isoform X1. (399 aa)
	VPS36	Vacuolar protein-sorting-associated protein 36 isoform X2. (367 aa)
	VPS37B	Vacuolar protein sorting-associated protein 37B. (332 aa)
	CHMP3	Charged multivesicular body protein 3 isoform X2. (249 aa)
	TM9SF1	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (606 aa)
	CHMP4A	Charged multivesicular body protein 4a isoform X2. (222 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP1A	CHMP2A	ENSVVUP00000004967	ENSVVUP00000004080	Charged multivesicular body protein 1a.	Charged multivesicular body protein 2a isoform X2.	0.997
CHMP1A	CHMP2B	ENSVVUP00000004967	ENSVVUP00000026088	Charged multivesicular body protein 1a.	Charged multivesicular body protein 2b.	0.978
CHMP1A	CHMP3	ENSVVUP00000004967	ENSVVUP00000040288	Charged multivesicular body protein 1a.	Charged multivesicular body protein 3 isoform X2.	0.971
CHMP1A	CHMP4A	ENSVVUP00000004967	ENSVVUP00000040968	Charged multivesicular body protein 1a.	Charged multivesicular body protein 4a isoform X2.	0.538
CHMP1A	CHMP4B	ENSVVUP00000004967	ENSVVUP00000005846	Charged multivesicular body protein 1a.	Charged multivesicular body protein 4b.	0.903
CHMP1A	CHMP4C	ENSVVUP00000004967	ENSVVUP00000001415	Charged multivesicular body protein 1a.	Charged multivesicular body protein 4c.	0.912
CHMP1A	CHMP5	ENSVVUP00000004967	ENSVVUP00000028868	Charged multivesicular body protein 1a.	Charged multivesicular body protein 5.	0.942
CHMP1A	CHMP6	ENSVVUP00000004967	ENSVVUP00000025291	Charged multivesicular body protein 1a.	Charged multivesicular body protein 6.	0.710
CHMP1A	CHMP7	ENSVVUP00000004967	ENSVVUP00000006564	Charged multivesicular body protein 1a.	Charged multivesicular body protein 7.	0.777
CHMP1A	ENSVVUP00000002781	ENSVVUP00000004967	ENSVVUP00000002781	Charged multivesicular body protein 1a.	annotation not available	0.511
CHMP1A	ENSVVUP00000034315	ENSVVUP00000004967	ENSVVUP00000034315	Charged multivesicular body protein 1a.	annotation not available	0.565
CHMP1A	ENSVVUP00000036810	ENSVVUP00000004967	ENSVVUP00000036810	Charged multivesicular body protein 1a.	annotation not available	0.406
CHMP1A	HGS	ENSVVUP00000004967	ENSVVUP00000027209	Charged multivesicular body protein 1a.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.492
CHMP1A	IST1	ENSVVUP00000004967	ENSVVUP00000024014	Charged multivesicular body protein 1a.	IST1 homolog isoform X1.	0.986
CHMP1A	MVB12A	ENSVVUP00000004967	ENSVVUP00000021912	Charged multivesicular body protein 1a.	Multivesicular body subunit 12A isoform X1.	0.651
CHMP1A	MVB12B	ENSVVUP00000004967	ENSVVUP00000013967	Charged multivesicular body protein 1a.	Multivesicular body subunit 12B isoform X2.	0.661
CHMP1A	PDCD6IP	ENSVVUP00000004967	ENSVVUP00000030217	Charged multivesicular body protein 1a.	Programmed cell death 6-interacting protein isoform X2.	0.431
CHMP1A	SNF8	ENSVVUP00000004967	ENSVVUP00000004362	Charged multivesicular body protein 1a.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.710
CHMP1A	SPAST	ENSVVUP00000004967	ENSVVUP00000011484	Charged multivesicular body protein 1a.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.546
CHMP1A	STAM	ENSVVUP00000004967	ENSVVUP00000005086	Charged multivesicular body protein 1a.	Signal transducing adapter molecule 1 isoform X1.	0.497