(13 nodes) Non-lytic viral release, and MIT domain binding network (Vulpes vulpes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHMP4C	Charged multivesicular body protein 4c. (236 aa)
	CHMP2A	Charged multivesicular body protein 2a isoform X2. (222 aa)
	CHMP1A	Charged multivesicular body protein 1a. (210 aa)
	VTA1	Vacuolar protein sorting-associated protein VTA1 homolog isoform X1. (306 aa)
	CHMP7	Charged multivesicular body protein 7. (450 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (540 aa)
	VPS4A	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (518 aa)
	IST1	IST1 homolog isoform X1. (366 aa)
	VPS4B	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (461 aa)
	CHMP6	Charged multivesicular body protein 6. (184 aa)
	CHMP2B	Charged multivesicular body protein 2b. (221 aa)
	CHMP5	Charged multivesicular body protein 5. (288 aa)
	CHMP3	Charged multivesicular body protein 3 isoform X2. (249 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP1A	CHMP2A	ENSVVUP00000004967	ENSVVUP00000004080	Charged multivesicular body protein 1a.	Charged multivesicular body protein 2a isoform X2.	0.997
CHMP1A	CHMP2B	ENSVVUP00000004967	ENSVVUP00000026088	Charged multivesicular body protein 1a.	Charged multivesicular body protein 2b.	0.978
CHMP1A	CHMP3	ENSVVUP00000004967	ENSVVUP00000040288	Charged multivesicular body protein 1a.	Charged multivesicular body protein 3 isoform X2.	0.971
CHMP1A	CHMP4C	ENSVVUP00000004967	ENSVVUP00000001415	Charged multivesicular body protein 1a.	Charged multivesicular body protein 4c.	0.912
CHMP1A	CHMP5	ENSVVUP00000004967	ENSVVUP00000028868	Charged multivesicular body protein 1a.	Charged multivesicular body protein 5.	0.942
CHMP1A	CHMP6	ENSVVUP00000004967	ENSVVUP00000025291	Charged multivesicular body protein 1a.	Charged multivesicular body protein 6.	0.710
CHMP1A	CHMP7	ENSVVUP00000004967	ENSVVUP00000006564	Charged multivesicular body protein 1a.	Charged multivesicular body protein 7.	0.777
CHMP1A	IST1	ENSVVUP00000004967	ENSVVUP00000024014	Charged multivesicular body protein 1a.	IST1 homolog isoform X1.	0.986
CHMP1A	SPAST	ENSVVUP00000004967	ENSVVUP00000011484	Charged multivesicular body protein 1a.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.546
CHMP1A	VPS4A	ENSVVUP00000004967	ENSVVUP00000023183	Charged multivesicular body protein 1a.	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family.	0.993
CHMP1A	VPS4B	ENSVVUP00000004967	ENSVVUP00000024231	Charged multivesicular body protein 1a.	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family.	0.992
CHMP1A	VTA1	ENSVVUP00000004967	ENSVVUP00000005772	Charged multivesicular body protein 1a.	Vacuolar protein sorting-associated protein VTA1 homolog isoform X1.	0.997
CHMP2A	CHMP1A	ENSVVUP00000004080	ENSVVUP00000004967	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 1a.	0.997
CHMP2A	CHMP2B	ENSVVUP00000004080	ENSVVUP00000026088	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 2b.	0.983
CHMP2A	CHMP3	ENSVVUP00000004080	ENSVVUP00000040288	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 3 isoform X2.	0.987
CHMP2A	CHMP4C	ENSVVUP00000004080	ENSVVUP00000001415	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 4c.	0.957
CHMP2A	CHMP5	ENSVVUP00000004080	ENSVVUP00000028868	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 5.	0.963
CHMP2A	CHMP6	ENSVVUP00000004080	ENSVVUP00000025291	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 6.	0.965
CHMP2A	CHMP7	ENSVVUP00000004080	ENSVVUP00000006564	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 7.	0.910
CHMP2A	IST1	ENSVVUP00000004080	ENSVVUP00000024014	Charged multivesicular body protein 2a isoform X2.	IST1 homolog isoform X1.	0.936