(62 nodes) Mixed, incl. Nuclear hormone receptor, and NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux network (Vulpes vulpes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NR5A2	Nuclear receptor subfamily 5 group A member 2 isoform X1. (519 aa)
	RARA	Retinoic acid receptor alpha isoform X2. (500 aa)
	TBL1XR1	F-box-like/WD repeat-containing protein TBL1XR1 isoform X1. (573 aa)
	THRA	Thyroid hormone receptor alpha. (492 aa)
	CRABP1	Cellular retinoic acid-binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (131 aa)
	TLE2	Transducin-like enhancer protein 2 isoform X3. (738 aa)
	FOXA3	Hepatocyte nuclear factor 3-gamma. (369 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2 isoform X1. (821 aa)
	EPAS1	Endothelial PAS domain-containing protein 1. (926 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
	LOC112922136	Histone-arginine methyltransferase CARM1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (457 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (516 aa)
	EP300	Histone acetyltransferase p300 isoform X1. (2430 aa)
	NR5A1	Steroidogenic factor 1. (461 aa)
	RXRG	Retinoic acid receptor RXR-gamma. (538 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
	NR0B2	Nuclear receptor subfamily 0 group B member 2. (279 aa)
	NR0B1	LOW QUALITY PROTEIN: nuclear receptor subfamily 0 group B member 1. (106 aa)
	NRF1	Nuclear respiratory factor 1 isoform X6. (503 aa)
	CIR1	Corepressor interacting with RBPJ 1. (477 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (817 aa)
	NCOA1	Nuclear receptor coactivator. (1483 aa)
	TLE3	Transducin-like enhancer protein 3 isoform X6. (713 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
	TRPS1	Zinc finger transcription factor Trps1 isoform X2. (1296 aa)
	HDAC1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (489 aa)
	PLAC8	Placenta-specific gene 8 protein. (212 aa)
	CREBBP	CREB-binding protein isoform X1. (2442 aa)
	CEBPA	CCAAT/enhancer-binding protein alpha. (197 aa)
	NCOA3	Nuclear receptor coactivator. (1440 aa)
	CARM1	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (778 aa)
	PRMT8	Protein arginine N-methyltransferase 8 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
	PML	Protein PML. (406 aa)
	NR1H4	Bile acid receptor isoform X2. (481 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein. (517 aa)
	NCOA2	Nuclear receptor coactivator. (1485 aa)
	TBL1X	F-box-like/WD repeat-containing protein TBL1X isoform X2. (526 aa)
	SIN3A	Paired amphipathic helix protein Sin3a. (1274 aa)
	NR1H2	Oxysterols receptor LXR-beta. (457 aa)
	HDAC3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
	FOXA1	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha. (440 aa)
	SPI1	Transcription factor PU.1 isoform X1. (358 aa)
	NRIP1	Nuclear receptor-interacting protein 1. (1118 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
	RXRB	Retinoic acid receptor RXR-beta. (525 aa)
	HDAC10	Histone deacetylase 10 isoform X5. (641 aa)
	SPDEF	SAM pointed domain-containing Ets transcription factor isoform X1. (337 aa)
	NR1H3	Oxysterols receptor LXR-alpha. (447 aa)
	NPAS4	Neuronal PAS domain-containing protein 4 isoform X2. (788 aa)
	NCOR2	Nuclear receptor corepressor 2 isoform X9. (2529 aa)
	ABCA1	ATP-binding cassette sub-family A member 1. (2230 aa)
	RXRA	Retinoic acid receptor RXR-alpha isoform X1. (568 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	RARG	Retinoic acid receptor gamma isoform X1. (648 aa)
	RARB	Retinoic acid receptor beta isoform X2. (448 aa)
	THRB	Thyroid hormone receptor beta isoform X2. (510 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (579 aa)
	ESR2	Estrogen receptor beta. (530 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha. (764 aa)
	ESRRA	Steroid hormone receptor ERR1 isoform X2. (544 aa)
	NCOR1	Nuclear receptor corepressor 1 isoform X5. (2521 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ESR1	ENSVVUP00000038260	ENSVVUP00000008408	ATP-binding cassette sub-family A member 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.509
ABCA1	NR1H2	ENSVVUP00000038260	ENSVVUP00000027585	ATP-binding cassette sub-family A member 1.	Oxysterols receptor LXR-beta.	0.953
ABCA1	NR1H3	ENSVVUP00000038260	ENSVVUP00000036555	ATP-binding cassette sub-family A member 1.	Oxysterols receptor LXR-alpha.	0.795
ABCA1	NR1H4	ENSVVUP00000038260	ENSVVUP00000025261	ATP-binding cassette sub-family A member 1.	Bile acid receptor isoform X2.	0.562
ABCA1	PPARA	ENSVVUP00000038260	ENSVVUP00000034480	ATP-binding cassette sub-family A member 1.	Peroxisome proliferator-activated receptor alpha isoform X1.	0.453
ABCA1	PPARG	ENSVVUP00000038260	ENSVVUP00000020742	ATP-binding cassette sub-family A member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.606
ABCA1	RXRA	ENSVVUP00000038260	ENSVVUP00000038604	ATP-binding cassette sub-family A member 1.	Retinoic acid receptor RXR-alpha isoform X1.	0.928
ABCA1	RXRB	ENSVVUP00000038260	ENSVVUP00000035105	ATP-binding cassette sub-family A member 1.	Retinoic acid receptor RXR-beta.	0.432
ABCA1	RXRG	ENSVVUP00000038260	ENSVVUP00000013817	ATP-binding cassette sub-family A member 1.	Retinoic acid receptor RXR-gamma.	0.576
ARNT	ARNT2	ENSVVUP00000015795	ENSVVUP00000006074	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Aryl hydrocarbon receptor nuclear translocator 2 isoform X1.	0.901
ARNT	CARM1	ENSVVUP00000015795	ENSVVUP00000024306	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.404
ARNT	CREBBP	ENSVVUP00000015795	ENSVVUP00000022118	Aryl hydrocarbon receptor nuclear translocator isoform X1.	CREB-binding protein isoform X1.	0.924
ARNT	EP300	ENSVVUP00000015795	ENSVVUP00000009208	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Histone acetyltransferase p300 isoform X1.	0.924
ARNT	EPAS1	ENSVVUP00000015795	ENSVVUP00000007195	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Endothelial PAS domain-containing protein 1.	0.999
ARNT	ESR1	ENSVVUP00000015795	ENSVVUP00000008408	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.437
ARNT	HDAC3	ENSVVUP00000015795	ENSVVUP00000028194	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.405
ARNT	HIF1A	ENSVVUP00000015795	ENSVVUP00000041360	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Hypoxia-inducible factor 1-alpha.	0.999
ARNT	LOC112922136	ENSVVUP00000015795	ENSVVUP00000008772	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Histone-arginine methyltransferase CARM1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.404
ARNT	NPAS4	ENSVVUP00000015795	ENSVVUP00000037811	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Neuronal PAS domain-containing protein 4 isoform X2.	0.998
ARNT	NR5A1	ENSVVUP00000015795	ENSVVUP00000013420	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Steroidogenic factor 1.	0.517