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| | MCM3 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (253 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | ENSVVUP00000000565 | annotation not available (253 aa) |
| | CLSPN | Claspin isoform X2. (667 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (516 aa) |
| | XRCC3 | DNA repair protein XRCC3. (349 aa) |
| | ENSVVUP00000001281 | annotation not available (486 aa) |
| | DBF4 | Activator of S phase kinase. (79 aa) |
| | ORC6 | Origin recognition complex subunit 6. (392 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (792 aa) |
| | ENSVVUP00000002949 | annotation not available (75 aa) |
| | RAD54B | DNA repair and recombination protein RAD54B isoform X3. (113 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (306 aa) |
| | CDT1 | DNA replication factor Cdt1. (512 aa) |
| | RAD51B | DNA repair protein RAD51 homolog 2 isoform X3. (271 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (900 aa) |
| | POLE4 | DNA polymerase epsilon subunit 4. (118 aa) |
| | MYRF-2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa) |
| | EME1 | Crossover junction endonuclease EME1. (579 aa) |
| | MLH3 | DNA mismatch repair protein Mlh3 isoform X1. (1456 aa) |
| | MGMT | methylated-DNA--protein-cysteine methyltransferase. (237 aa) |
| | MCM10 | Protein MCM10 homolog. (875 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (852 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1 isoform X2. (1512 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa) |
| | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3. (1082 aa) |
| | BLM | Bloom syndrome protein. (1420 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa) |
| | REV3L | DNA polymerase zeta catalytic subunit isoform X2. (3138 aa) |
| | LOC112926201 | LOW QUALITY PROTEIN: replication factor C subunit 5-like. (304 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17 isoform X1. (680 aa) |
| | FBH1 | F-box DNA helicase 1. (1163 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like. (747 aa) |
| | XRCC2 | DNA repair protein XRCC2. (279 aa) |
| | MLH1 | DNA mismatch repair protein Mlh1 isoform X1. (759 aa) |
| | RMI1 | recQ-mediated genome instability protein 1. (649 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (469 aa) |
| | TM4SF19 | Transmembrane 4 L6 family member 19. (209 aa) |
| | PRIM2 | DNA primase large subunit. (469 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (719 aa) |
| | TP53BP1 | TP53-binding protein 1 isoform X1. (1976 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein. (471 aa) |
| | ORC3 | Origin recognition complex subunit 3 isoform X1. (772 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (397 aa) |
| | POLD4 | DNA polymerase delta subunit 4. (107 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | MCMBP | Mini-chromosome maintenance complex-binding protein isoform X2. (635 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ANKRD12 | Ankyrin repeat domain-containing protein 12 isoform X1. (2061 aa) |
| | ATAD5 | ATPase family AAA domain-containing protein 5. (1882 aa) |
| | RPA2 | Replication protein A 32 kDa subunit isoform X2. (269 aa) |
| | CHTF18 | Chromosome transmission fidelity protein 18 homolog. (1099 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | RAD51C | DNA repair protein RAD51 homolog 3 isoform X1. (382 aa) |
| | RFC5 | Replication factor C subunit 5. (331 aa) |
| | RFC4 | Replication factor C subunit 4. (424 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (265 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | RFC1 | Replication factor C subunit 1. (1166 aa) |
| | GEN1 | Flap endonuclease GEN homolog 1. (906 aa) |
| | POLI | DNA polymerase iota isoform X3. (704 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1232 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2 isoform X1. (995 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3060 aa) |
| | MCM9 | DNA helicase MCM9 isoform X1; Belongs to the MCM family. (1141 aa) |
| | DSCC1 | Sister chromatid cohesion protein DCC1 isoform X1. (422 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (245 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4. (1743 aa) |
| | RAD9B | Cell cycle checkpoint control protein RAD9B. (421 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (865 aa) |
| | ENSVVUP00000024478 | annotation not available (157 aa) |
| | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (255 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1272 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | MCMDC2 | Minichromosome maintenance domain-containing protein 2. (681 aa) |
| | ORC2 | Origin recognition complex subunit 2. (574 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1455 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (863 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1054 aa) |
| | RAD52 | DNA repair protein RAD52 homolog. (758 aa) |
| | RAD51D | DNA repair protein RAD51 homolog 4 isoform X1. (328 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase. (576 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa) |
| | MSH5 | mutS protein homolog 5. (846 aa) |
| | TIMELESS | Protein timeless homolog isoform X1. (1248 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | LOC112913400 | Protein DBF4 homolog A. (629 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor protein 1. (1059 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (281 aa) |
| | GINS1 | DNA replication complex GINS protein PSF1 isoform X2. (224 aa) |
| | DMC1 | Meiotic recombination protein DMC1/LIM15 homolog; Belongs to the RecA family. (333 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (653 aa) |
| | MCM8 | DNA helicase MCM8; Belongs to the MCM family. (868 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (763 aa) |
| | GINS3 | DNA replication complex GINS protein PSF3. (228 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1891 aa) |
| | ATR | Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2637 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | POLD3 | DNA polymerase delta subunit 3 isoform X1. (466 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1312 aa) |
| | RFC2 | Replication factor C subunit 2 isoform X1. (496 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1113 aa) |
| | POLK | DNA polymerase kappa isoform X1. (861 aa) |
| | CDC45 | Cell division control protein 45 homolog. (569 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2 isoform X1. (544 aa) |
| | SLX1A | SLX1 homolog A, structure-specific endonuclease subunit. (161 aa) |
| | EXO1 | Exonuclease 1. (844 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3446 aa) |
| | RFC3 | Replication factor C subunit 3 isoform X1. (355 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (348 aa) |
| | MUS81 | Crossover junction endonuclease MUS81 isoform X2. (697 aa) |
| | PMS1 | PMS1 protein homolog 1 isoform X1. (930 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (586 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa) |
| | POLH | DNA polymerase eta isoform X1. (709 aa) |
| | TDRD3 | Tudor domain-containing protein 3 isoform X3. (799 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (297 aa) |
| | MCPH1 | Microcephalin. (829 aa) |
| | WDHD1 | WD repeat and HMG-box DNA-binding protein 1. (1116 aa) |
| | ATRIP | ATR-interacting protein isoform X2. (792 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (813 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (987 aa) |
