STRINGSTRING
MCM3 MCM3 GINS4 GINS4 GINS2 GINS2 ENSVVUP00000000565 ENSVVUP00000000565 CDC6 CDC6 ENSVVUP00000001281 ENSVVUP00000001281 DBF4 DBF4 ORC6 ORC6 ENSVVUP00000002949 ENSVVUP00000002949 POLE3 POLE3 CDT1 CDT1 POLE4 POLE4 MYRF-2 MYRF-2 ORC1 ORC1 MCM10 MCM10 POLE POLE REV3L REV3L LOC112926201 LOC112926201 MCM6 MCM6 POLD2 POLD2 TM4SF19 TM4SF19 PRIM2 PRIM2 ORC3 ORC3 POLD4 POLD4 ORC4 ORC4 MCMBP MCMBP ATAD5 ATAD5 CHTF18 CHTF18 POLA1 POLA1 RFC5 RFC5 RFC4 RFC4 TIPIN TIPIN ORC5 ORC5 RFC1 RFC1 POLI POLI MCM9 MCM9 DSCC1 DSCC1 MCM4 MCM4 MCM2 MCM2 MCMDC2 MCMDC2 ORC2 ORC2 WRN WRN POLD1 POLD1 DNA2 DNA2 CDC7 CDC7 PRIM1 PRIM1 TIMELESS TIMELESS LOC112913400 LOC112913400 GINS1 GINS1 MCM7 MCM7 MCM8 MCM8 MCM5 MCM5 GINS3 GINS3 PCNA PCNA POLD3 POLD3 RFC2 RFC2 POLK POLK CDC45 CDC45 RFC3 RFC3 POLA2 POLA2 MAD2L2 MAD2L2 REV1 REV1 POLH POLH WDHD1 WDHD1 POLE2 POLE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM3DNA helicase; Belongs to the MCM family. (825 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (253 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
ENSVVUP00000000565annotation not available (253 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (516 aa)
ENSVVUP00000001281annotation not available (486 aa)
DBF4Activator of S phase kinase. (79 aa)
ORC6Origin recognition complex subunit 6. (392 aa)
ENSVVUP00000002949annotation not available (75 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (306 aa)
CDT1DNA replication factor Cdt1. (512 aa)
POLE4DNA polymerase epsilon subunit 4. (118 aa)
MYRF-2Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
MCM10Protein MCM10 homolog. (875 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa)
REV3LDNA polymerase zeta catalytic subunit isoform X2. (3138 aa)
LOC112926201LOW QUALITY PROTEIN: replication factor C subunit 5-like. (304 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
TM4SF19Transmembrane 4 L6 family member 19. (209 aa)
PRIM2DNA primase large subunit. (469 aa)
ORC3Origin recognition complex subunit 3 isoform X1. (772 aa)
POLD4DNA polymerase delta subunit 4. (107 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
MCMBPMini-chromosome maintenance complex-binding protein isoform X2. (635 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1882 aa)
CHTF18Chromosome transmission fidelity protein 18 homolog. (1099 aa)
POLA1DNA polymerase. (1467 aa)
RFC5Replication factor C subunit 5. (331 aa)
RFC4Replication factor C subunit 4. (424 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (265 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
RFC1Replication factor C subunit 1. (1166 aa)
POLIDNA polymerase iota isoform X3. (704 aa)
MCM9DNA helicase MCM9 isoform X1; Belongs to the MCM family. (1141 aa)
DSCC1Sister chromatid cohesion protein DCC1 isoform X1. (422 aa)
MCM4DNA helicase; Belongs to the MCM family. (865 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
MCMDC2Minichromosome maintenance domain-containing protein 2. (681 aa)
ORC2Origin recognition complex subunit 2. (574 aa)
WRNWerner syndrome ATP-dependent helicase. (1455 aa)
POLD1DNA polymerase. (1107 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1054 aa)
CDC7Cell division cycle 7-related protein kinase. (576 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
TIMELESSProtein timeless homolog isoform X1. (1248 aa)
LOC112913400Protein DBF4 homolog A. (629 aa)
GINS1DNA replication complex GINS protein PSF1 isoform X2. (224 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (653 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (868 aa)
MCM5DNA helicase; Belongs to the MCM family. (763 aa)
GINS3DNA replication complex GINS protein PSF3. (228 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLD3DNA polymerase delta subunit 3 isoform X1. (466 aa)
RFC2Replication factor C subunit 2 isoform X1. (496 aa)
POLKDNA polymerase kappa isoform X1. (861 aa)
CDC45Cell division control protein 45 homolog. (569 aa)
RFC3Replication factor C subunit 3 isoform X1. (355 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (586 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa)
POLHDNA polymerase eta isoform X1. (709 aa)
WDHD1WD repeat and HMG-box DNA-binding protein 1. (1116 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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