STRINGSTRING
NEK2 NEK2 EFHC1 EFHC1 SGO1 SGO1 LOC112927180 LOC112927180 TUBGCP2 TUBGCP2 GPSM2 GPSM2 CDC6 CDC6 PSRC1 PSRC1 WDR60 WDR60 BEX4 BEX4 RMDN1 RMDN1 ALPK1 ALPK1 BOD1 BOD1 AURKC AURKC CALM3 CALM3 SPDL1 SPDL1 ENSVVUP00000003811 ENSVVUP00000003811 TUBGCP5 TUBGCP5 NEDD9 NEDD9 MAD1L1 MAD1L1 ENSVVUP00000005393 ENSVVUP00000005393 CETN1 CETN1 DCTN1 DCTN1 ENSVVUP00000005911 ENSVVUP00000005911 DYNC1LI1 DYNC1LI1 KATNA1 KATNA1 LATS1 LATS1 KIF2A KIF2A CTNNB1 CTNNB1 MAPRE1-2 MAPRE1-2 EFCAB3 EFCAB3 BCCIP BCCIP PLK1 PLK1 ABRAXAS2 ABRAXAS2 WDR73 WDR73 CEP95 CEP95 ENSVVUP00000009373 ENSVVUP00000009373 CALML5 CALML5 MAP10 MAP10 YPEL5 YPEL5 LATS2 LATS2 HSF1 HSF1 PLK3 PLK3 SMC3 SMC3 FAM110A FAM110A LOC112911667 LOC112911667 CENPF CENPF TPX2 TPX2 SPAST SPAST CEP19 CEP19 ENSVVUP00000011611 ENSVVUP00000011611 UBL3 UBL3 KATNAL1 KATNAL1 LOC112908355 LOC112908355 NUP62CL NUP62CL TUBGCP4 TUBGCP4 NUBP2 NUBP2 MAPRE1 MAPRE1 PLK4 PLK4 AUNIP AUNIP POC1B POC1B ENSVVUP00000015848 ENSVVUP00000015848 CEP85 CEP85 MTCL1 MTCL1 CDK5RAP2 CDK5RAP2 BIRC6 BIRC6 LOC112915139 LOC112915139 TBCCD1 TBCCD1 IK IK WDR62 WDR62 RAB11A RAB11A SMC6 SMC6 FBF1 FBF1 BOD1L1 BOD1L1 RAD21 RAD21 ODF2 ODF2 DYNC1I1 DYNC1I1 ZW10 ZW10 SBDS SBDS CEP89 CEP89 UNC119 UNC119 CEP44 CEP44 SPAG5 SPAG5 VPS4A VPS4A RSKR RSKR RAE1 RAE1 AURKA AURKA UXT UXT CEP128 CEP128 VPS4B VPS4B UBXN2B UBXN2B LOC112914557 LOC112914557 CALM1 CALM1 KNTC1 KNTC1 CSPP1 CSPP1 NEDD1 NEDD1 RMDN2 RMDN2 CTDP1 CTDP1 NDE1 NDE1 TNKS TNKS TUBGCP3 TUBGCP3 PPP2CB PPP2CB BRCC3 BRCC3 GIT1 GIT1 TOPORS TOPORS PPP2CA PPP2CA PLK2 PLK2 KIF11 KIF11 CDC14A CDC14A CCDC155 CCDC155 PLK5 PLK5 CDC14B CDC14B UMOD UMOD KATNB1 KATNB1 KLHL22 KLHL22 TUBG1 TUBG1 TUBG1-2 TUBG1-2 CDC25B CDC25B ENSVVUP00000034938 ENSVVUP00000034938 TUBGCP6 TUBGCP6 RAB11B RAB11B NUMA1 NUMA1 ENSVVUP00000035680 ENSVVUP00000035680 SPOUT1 SPOUT1 CUL3 CUL3 TMEM201 TMEM201 NOL9 NOL9 CKAP5 CKAP5 POC1A POC1A MAPKBP1 MAPKBP1 KAT5 KAT5 ANKRD53 ANKRD53 HAUS1 HAUS1 AAAS AAAS AURKB AURKB KATNAL2 KATNAL2 EML1 EML1 TPT1 TPT1 CKAP2L CKAP2L ENSVVUP00000040212 ENSVVUP00000040212 STAG2 STAG2 FAM83D FAM83D EMD EMD DLGAP5 DLGAP5 NIN NIN SMC1A SMC1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NEK2Serine/threonine-protein kinase Nek2. (444 aa)
EFHC1EF-hand domain-containing protein 1. (688 aa)
SGO1Shugoshin 1. (524 aa)
LOC112927180Calmodulin-alpha-like. (81 aa)
TUBGCP2Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (904 aa)
GPSM2G-protein-signaling modulator 2 isoform X1. (693 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (516 aa)
PSRC1Proline/serine-rich coiled-coil protein 1 isoform X1. (364 aa)
WDR60WD repeat-containing protein 60 isoform X1. (1031 aa)
BEX4Protein BEX4. (118 aa)
RMDN1Regulator of microtubule dynamics protein 1 isoform X1. (317 aa)
ALPK1Alpha-protein kinase 1 isoform X1. (1237 aa)
BOD1Biorientation of chromosomes in cell division protein 1. (288 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
CALM3Calmodulin-1; Belongs to the calmodulin family. (149 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (621 aa)
ENSVVUP00000003811annotation not available (192 aa)
TUBGCP5Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (690 aa)
NEDD9Enhancer of filamentation 1 isoform X2. (834 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X1. (782 aa)
ENSVVUP00000005393annotation not available (155 aa)
CETN1Centrin-1. (172 aa)
DCTN1Dynactin subunit 1 isoform X6. (1285 aa)
ENSVVUP00000005911annotation not available (91 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (495 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (628 aa)
LATS1Serine/threonine-protein kinase LATS1 isoform X1. (1127 aa)
KIF2AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (729 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
MAPRE1-2Microtubule-associated protein RP/EB family member 1. (126 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3. (438 aa)
BCCIPBRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family. (314 aa)
PLK1Serine/threonine-protein kinase PLK. (607 aa)
ABRAXAS2BRISC complex subunit Abraxas 2. (440 aa)
WDR73WD repeat-containing protein 73 isoform X1. (427 aa)
CEP95Centrosomal protein of 95 kDa. (816 aa)
ENSVVUP00000009373annotation not available (154 aa)
CALML5Calmodulin-like protein 5. (149 aa)
MAP10Microtubule-associated protein 10. (863 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
LATS2Non-specific serine/threonine protein kinase. (1085 aa)
HSF1Heat shock factor protein 1 isoform X2. (554 aa)
PLK3Serine/threonine-protein kinase PLK. (886 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
FAM110AProtein FAM110A. (422 aa)
LOC112911667E3 ubiquitin-protein ligase Topors-like. (739 aa)
CENPFCentromere protein F. (3062 aa)
TPX2Targeting protein for Xklp2. (740 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (540 aa)
CEP19Centrosomal protein of 19 kDa. (163 aa)
ENSVVUP00000011611annotation not available (205 aa)
UBL3Ubiquitin-like protein. (121 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (532 aa)
LOC112908355LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like. (270 aa)
NUP62CLNucleoporin-62 C-terminal-like protein isoform X1. (179 aa)
TUBGCP4Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (666 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (295 aa)
MAPRE1Microtubule-associated protein RP/EB family member 1. (195 aa)
PLK4Serine/threonine-protein kinase PLK4. (968 aa)
AUNIPAurora kinase A and ninein-interacting protein. (416 aa)
POC1BPOC1 centriolar protein homolog B isoform X4. (208 aa)
ENSVVUP00000015848annotation not available (142 aa)
CEP85Centrosomal protein of 85 kDa. (767 aa)
MTCL1Microtubule cross-linking factor 1 isoform X1. (1688 aa)
CDK5RAP2CDK5 regulatory subunit-associated protein 2. (1889 aa)
BIRC6Baculoviral IAP repeat-containing protein 6 isoform X3. (4983 aa)
LOC112915139Protein yippee-like 5. (121 aa)
TBCCD1TBCC domain-containing protein 1. (557 aa)
IKProtein Red. (845 aa)
WDR62LOW QUALITY PROTEIN: WD repeat-containing protein 62. (1558 aa)
RAB11ARas-related protein Rab-11A. (216 aa)
SMC6Structural maintenance of chromosomes protein 6. (1096 aa)
FBF1Fas-binding factor 1 isoform X2. (1173 aa)
BOD1L1Biorientation of chromosomes in cell division protein 1-like 1. (2830 aa)
RAD21Double-strand-break repair protein rad21 homolog. (631 aa)
ODF2Outer dense fiber protein 2 isoform X4. (829 aa)
DYNC1I1Cytoplasmic dynein 1 intermediate chain 1 isoform X2. (703 aa)
ZW10Centromere/kinetochore protein zw10 homolog isoform X1. (779 aa)
SBDSRibosome maturation protein SBDS. (250 aa)
CEP89Centrosomal protein of 89 kDa isoform X1. (833 aa)
UNC119Protein unc-119 homolog A. (242 aa)
CEP44Centrosomal protein of 44 kDa isoform X1. (386 aa)
SPAG5Sperm-associated antigen 5 isoform X3. (1088 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (518 aa)
RSKRUncharacterized serine/threonine-protein kinase SgK494 isoform X2. (393 aa)
RAE1mRNA export factor. (371 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (386 aa)
UXTProtein UXT isoform X2. (157 aa)
CEP128Centrosomal protein of 128 kDa. (1135 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (461 aa)
UBXN2BUBX domain-containing protein 2B. (330 aa)
LOC112914557Protein BEX4-like. (118 aa)
CALM1Calmodulin 1. (149 aa)
KNTC1Kinetochore-associated protein 1. (2221 aa)
CSPP1Centrosome and spindle pole-associated protein 1 isoform X1. (1144 aa)
NEDD1Protein NEDD1 isoform X2. (658 aa)
RMDN2Regulator of microtubule dynamics protein 2. (504 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (878 aa)
NDE1Nuclear distribution protein nudE homolog 1. (346 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
TUBGCP3Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (907 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (263 aa)
GIT1ARF GTPase-activating protein GIT1. (798 aa)
TOPORSE3 ubiquitin-protein ligase Topors. (1043 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PLK2Serine/threonine-protein kinase PLK2. (639 aa)
KIF11Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1099 aa)
CDC14ADual specificity protein phosphatase CDC14A isoform X2. (611 aa)
CCDC155Protein KASH5. (616 aa)
PLK5Serine/threonine-protein kinase PLK. (632 aa)
CDC14BDual specificity protein phosphatase CDC14B isoform X5. (461 aa)
UMODUromodulin. (679 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (655 aa)
KLHL22Kelch-like protein 22. (634 aa)
TUBG1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (491 aa)
TUBG1-2Tubulin gamma-1 chain. (251 aa)
CDC25BM-phase inducer phosphatase 2 isoform X2. (533 aa)
ENSVVUP00000034938annotation not available (125 aa)
TUBGCP6LOW QUALITY PROTEIN: gamma-tubulin complex component 6. (1540 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2153 aa)
ENSVVUP00000035680annotation not available (126 aa)
SPOUT1Putative methyltransferase C9orf114 homolog isoform X1. (358 aa)
CUL3Cullin-3 isoform X1; Belongs to the cullin family. (755 aa)
TMEM201Transmembrane protein 201. (646 aa)
NOL9Polynucleotide 5'-hydroxyl-kinase NOL9. (1070 aa)
CKAP5Cytoskeleton-associated protein 5 isoform X1. (2033 aa)
POC1APOC1 centriolar protein homolog A isoform X2. (406 aa)
MAPKBP1Mitogen-activated protein kinase-binding protein 1 isoform X1. (1503 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa)
ANKRD53Ankyrin repeat domain-containing protein 53. (489 aa)
HAUS1HAUS augmin-like complex subunit 1. (273 aa)
AAASAladin isoform X1. (546 aa)
AURKBAurora kinase B isoform X3; Belongs to the protein kinase superfamily. (501 aa)
KATNAL2Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (588 aa)
EML1Echinoderm microtubule-associated protein-like 1. (866 aa)
TPT1Translationally-controlled tumor protein; Belongs to the TCTP family. (195 aa)
CKAP2LCytoskeleton-associated protein 2-like. (746 aa)
ENSVVUP00000040212annotation not available (169 aa)
STAG2Cohesin subunit SA-2 isoform X1. (1299 aa)
FAM83DProtein FAM83D. (420 aa)
EMDEmerin. (317 aa)
DLGAP5Disks large-associated protein 5. (845 aa)
NINNinein isoform X2. (2134 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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