STRINGSTRING
ENSVVUP00000025427 ENSVVUP00000025427 EDC3 EDC3 ETF1 ETF1 EIF3E EIF3E EIF4A3 EIF4A3 PATL1 PATL1 SSB SSB LSM2 LSM2 NBDY NBDY ATM ATM HELZ2 HELZ2 ENSVVUP00000020147 ENSVVUP00000020147 CTIF CTIF RC3H1 RC3H1 UPF3A UPF3A SMG8 SMG8 NUDT12 NUDT12 EXOSC9 EXOSC9 PABPC1 PABPC1 NBAS NBAS YTHDF2 YTHDF2 EDC4 EDC4 ENSVVUP00000016659 ENSVVUP00000016659 XRN2 XRN2 UPF3B UPF3B PATL2 PATL2 RIDA RIDA LOC112912449 LOC112912449 THRAP3 THRAP3 ZFP36L2 ZFP36L2 AGO3 AGO3 MAGOH MAGOH AGO1 AGO1 LOC112914685 LOC112914685 ENSVVUP00000000522 ENSVVUP00000000522 CASC3 CASC3 LRRC27 LRRC27 MTPAP MTPAP LSM7 LSM7 NANOS2 NANOS2 CNOT9 CNOT9 ZFP36L1 ZFP36L1 PABPN1L PABPN1L CNOT8 CNOT8 MAGOHB MAGOHB LOC112908264 LOC112908264 ZC3H12D ZC3H12D EXOSC5 EXOSC5 SMG5 SMG5 UPF2 UPF2 DDX5 DDX5 ZFP36 ZFP36 SAMD4B SAMD4B PNLDC1 PNLDC1 EXOSC7 EXOSC7 SND1 SND1 PNPT1 PNPT1 CSDE1 CSDE1 NCBP2L NCBP2L EXOSC4 EXOSC4 RC3H2 RC3H2 PAN3 PAN3 SWT1 SWT1 SMG7 SMG7 CNOT2 CNOT2 SMG9 SMG9 CNOT3 CNOT3 METTL14 METTL14 LSM4 LSM4 UPF1 UPF1 CNOT7 CNOT7 RBM8A RBM8A POLR2G POLR2G SAMD4A SAMD4A MRTO4 MRTO4 CNOT11 CNOT11 EXOSC2 EXOSC2 EXOSC10 EXOSC10 CNOT1 CNOT1 CNOT6 CNOT6 PNRC2 PNRC2 KHSRP KHSRP EXOSC8 EXOSC8 XRN1 XRN1 DCP2 DCP2 DIS3L2 DIS3L2 PELO PELO TENT2 TENT2 CNOT6L CNOT6L DHX34 DHX34 DCP1A DCP1A DXO DXO SKIV2L SKIV2L ZC3H12A ZC3H12A PYM1 PYM1 CNOT10 CNOT10 TTC37 TTC37 PAN2 PAN2 SMG6 SMG6 NOCT NOCT ENSVVUP00000029221 ENSVVUP00000029221 SMG1 SMG1 DCP1B DCP1B SUPV3L1 SUPV3L1 PDE12 PDE12 LSM1 LSM1 DCPS DCPS ZCCHC7 ZCCHC7 EXOSC3 EXOSC3 NCBP1 NCBP1 PARN PARN ENSVVUP00000026514 ENSVVUP00000026514
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSVVUP00000025427annotation not available (98 aa)
EDC3Enhancer of mRNA-decapping protein 3 isoform X2. (508 aa)
ETF1Eukaryotic peptide chain release factor subunit 1. (437 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (457 aa)
EIF4A3Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (411 aa)
PATL1Protein PAT1 homolog 1. (790 aa)
SSBLupus La protein. (523 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2. (81 aa)
NBDYNegative regulator of P-body association. (68 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3060 aa)
HELZ2Helicase with zinc finger domain 2. (2993 aa)
ENSVVUP00000020147annotation not available (94 aa)
CTIFCBP80/20-dependent translation initiation factor isoform X1. (622 aa)
RC3H1Roquin-1 isoform X1. (1136 aa)
UPF3ARegulator of nonsense transcripts 3A isoform X1. (519 aa)
SMG8Protein SMG8. (991 aa)
NUDT12Peroxisomal NADH pyrophosphatase NUDT12 isoform X1. (627 aa)
EXOSC9Exosome complex component RRP45. (440 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (565 aa)
NBASNeuroblastoma-amplified sequence. (2110 aa)
YTHDF2YTH domain-containing family protein 2. (580 aa)
EDC4Enhancer of mRNA-decapping protein 4. (1400 aa)
ENSVVUP00000016659annotation not available (74 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
UPF3BRegulator of nonsense transcripts 3B isoform X2. (464 aa)
PATL2Protein PAT1 homolog 2. (537 aa)
RIDA2-iminobutanoate/2-iminopropanoate deaminase isoform X2. (137 aa)
LOC112912449Proline-rich nuclear receptor coactivator 2-like. (139 aa)
THRAP3Thyroid hormone receptor-associated protein 3 isoform X2. (957 aa)
ZFP36L2LOW QUALITY PROTEIN: mRNA decay activator protein ZFP36L2. (601 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (845 aa)
MAGOHProtein mago nashi homolog. (146 aa)
AGO1Protein argonaute-1 isoform X2; Belongs to the argonaute family. (857 aa)
LOC112914685Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (794 aa)
ENSVVUP00000000522annotation not available (59 aa)
CASC3Protein CASC3. (703 aa)
LRRC27Leucine-rich repeat-containing protein 27 isoform X1. (533 aa)
MTPAPpoly(A) RNA polymerase, mitochondrial. (584 aa)
LSM7U6 snRNA-associated Sm-like protein LSm7. (109 aa)
NANOS2Nanos homolog 2; Belongs to the nanos family. (138 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (309 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
PABPN1LLOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2. (177 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
MAGOHBProtein mago nashi homolog 2. (148 aa)
LOC112908264Protein mago nashi homolog. (144 aa)
ZC3H12DProbable ribonuclease ZC3H12D. (157 aa)
EXOSC5Exosome complex component RRP46. (235 aa)
SMG5Protein SMG5 isoform X2. (1011 aa)
UPF2Regulator of nonsense transcripts 2 isoform X1. (1271 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
ZFP36mRNA decay activator protein ZFP36. (330 aa)
SAMD4BProtein Smaug homolog 2. (748 aa)
PNLDC1poly(A)-specific ribonuclease PNLDC1 isoform X1. (594 aa)
EXOSC7Exosome complex component RRP42 isoform X1. (291 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (784 aa)
CSDE1Cold shock domain-containing protein E1 isoform X3. (731 aa)
NCBP2LNuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (141 aa)
EXOSC4Exosome complex component RRP41. (245 aa)
RC3H2Roquin-2 isoform X1. (1188 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (955 aa)
SWT1Transcriptional protein SWT1 isoform X1. (898 aa)
SMG7Protein SMG7 isoform X3. (1191 aa)
CNOT2CCR4-NOT transcription complex subunit 2 isoform X3. (551 aa)
SMG9Protein SMG9 isoform X1. (520 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (799 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (507 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (195 aa)
UPF1Regulator of nonsense transcripts 1 isoform X2. (1119 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
POLR2GDNA-directed RNA polymerase II subunit RPB7 isoform X2. (172 aa)
SAMD4AProtein Smaug homolog 1 isoform X1. (718 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (240 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (508 aa)
EXOSC2Exosome complex component RRP4. (293 aa)
EXOSC10Exosome component 10. (803 aa)
CNOT1CCR4-NOT transcription complex subunit 1 isoform X1. (2376 aa)
CNOT6CCR4-NOT transcription complex subunit 6 isoform X1. (557 aa)
PNRC2Proline-rich nuclear receptor coactivator 2 isoform X3. (139 aa)
KHSRPFar upstream element-binding protein 2. (744 aa)
EXOSC8Exosome complex component RRP43. (463 aa)
XRN15'-3' exoribonuclease 1 isoform X2. (1731 aa)
DCP2m7GpppN-mRNA hydrolase. (422 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (881 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
TENT2poly(A) RNA polymerase GLD2 isoform X2. (480 aa)
CNOT6LCCR4-NOT transcription complex subunit 6-like. (608 aa)
DHX34Probable ATP-dependent RNA helicase DHX34. (1139 aa)
DCP1AmRNA-decapping enzyme 1A. (580 aa)
DXODecapping and exoribonuclease protein isoform X1. (397 aa)
SKIV2LHelicase SKI2W. (1246 aa)
ZC3H12AEndoribonuclease ZC3H12A. (578 aa)
PYM1Partner of Y14 and mago. (221 aa)
CNOT10CCR4-NOT transcription complex subunit 10 isoform X1. (803 aa)
TTC37Tetratricopeptide repeat protein 37. (1564 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
SMG6Telomerase-binding protein EST1A isoform X1. (1412 aa)
NOCTNocturnin isoform X1. (388 aa)
ENSVVUP00000029221annotation not available (69 aa)
SMG1Serine/threonine-protein kinase SMG1 isoform X1; Belongs to the PI3/PI4-kinase family. (3638 aa)
DCP1BmRNA-decapping enzyme 1B isoform X1. (612 aa)
SUPV3L1ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform X1. (846 aa)
PDE122',5'-phosphodiesterase 12. (625 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
DCPSm7GpppX diphosphatase. (388 aa)
ZCCHC7Zinc finger CCHC domain-containing protein 7. (457 aa)
EXOSC3Exosome complex component RRP40 isoform X1. (275 aa)
NCBP1Nuclear cap-binding protein subunit 1 isoform X1. (790 aa)
PARNpoly(A)-specific ribonuclease PARN. (638 aa)
ENSVVUP00000026514annotation not available (123 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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