STRINGSTRING
ELOVL5 ELOVL5 NR1D1 NR1D1 FGFR4 FGFR4 BMP5 BMP5 LOC112921570 LOC112921570 SCAP SCAP ENSVVUP00000003074 ENSVVUP00000003074 PLA2G3 PLA2G3 LOC112912760 LOC112912760 INS INS INSIG1 INSIG1 AKT1 AKT1 ANXA1 ANXA1 GIP GIP SIRT5 SIRT5 EIF6 EIF6 PDK2 PDK2 ATCAY ATCAY LOC112928185 LOC112928185 FGF19 FGF19 BMP6 BMP6 MFSD2A MFSD2A PRKCE PRKCE REST REST LOC112923739 LOC112923739 CD74 CD74 PRKAG2 PRKAG2 ENSVVUP00000010162 ENSVVUP00000010162 PROX1 PROX1 TRIB3 TRIB3 APOC2 APOC2 PLIN5 PLIN5 ENSVVUP00000011849 ENSVVUP00000011849 SOX9 SOX9 LPGAT1 LPGAT1 PRMT3 PRMT3 CAV1 CAV1 MALRD1 MALRD1 MID1IP1 MID1IP1 WDTC1 WDTC1 CLCN2 CLCN2 LOC112912623 LOC112912623 ETFBKMT ETFBKMT STARD4 STARD4 DGKQ DGKQ ADIPOQ ADIPOQ SLC45A3 SLC45A3 PDK1 PDK1 ATP2B4 ATP2B4 PPARG PPARG PDK4 PDK4 LONP2 LONP2 PPTC7 PPTC7 ABCD2 ABCD2 ABCB11 ABCB11 CYP7A1 CYP7A1 PIBF1 PIBF1 EGR1 EGR1 INSIG2 INSIG2 NR1H4 NR1H4 SLC7A7 SLC7A7 SIRT1 SIRT1 ERLIN2 ERLIN2 NR1H2 NR1H2 SIRT4 SIRT4 SLC7A11 SLC7A11 TYSND1 TYSND1 DKKL1 DKKL1 APPL2 APPL2 BMP2 BMP2 BRCA1 BRCA1 PANK2 PANK2 MLXIPL MLXIPL ERLIN1 ERLIN1 PPARA PPARA FMO4 FMO4 FMO1 FMO1 FMO2 FMO2 LOC112923472 LOC112923472 FMO3 FMO3 APOA4 APOA4 DKK3 DKK3 KCNMA1 KCNMA1 CLN3 CLN3 PPARD PPARD NR1H3 NR1H3 H6PD H6PD PARK7 PARK7 AKT3 AKT3 ENSVVUP00000037390 ENSVVUP00000037390 NCOR2 NCOR2 ACADVL ACADVL IL1B IL1B ENSVVUP00000041731 ENSVVUP00000041731 ABCD1 ABCD1 TREX1 TREX1 NCOR1 NCOR1 MLYCD MLYCD
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (336 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (617 aa)
FGFR4Fibroblast growth factor receptor. (844 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
LOC112921570Ankyrin repeat domain-containing protein 26-like isoform X1. (1689 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein. (1161 aa)
ENSVVUP00000003074annotation not available (314 aa)
PLA2G3LOW QUALITY PROTEIN: group 3 secretory phospholipase A2. (512 aa)
LOC112912760Ankyrin repeat domain-containing protein 26-like. (201 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (303 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ANXA1Annexin. (345 aa)
GIPGastric inhibitory polypeptide. (160 aa)
SIRT5Sirtuin 5. (315 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
PDK2Protein-serine/threonine kinase. (408 aa)
ATCAYCaytaxin. (411 aa)
LOC112928185NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (266 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
BMP6Bone morphogenetic protein 6. (418 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1. (523 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (750 aa)
RESTRE1-silencing transcription factor. (996 aa)
LOC112923739LOW QUALITY PROTEIN: fatty acid-binding protein 5. (104 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (272 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (257 aa)
ENSVVUP00000010162annotation not available (285 aa)
PROX1Prospero homeobox protein 1 isoform X2. (737 aa)
TRIB3Tribbles homolog 3. (358 aa)
APOC2Apolipoprotein C-II isoform X1. (101 aa)
PLIN5Perilipin; Belongs to the perilipin family. (499 aa)
ENSVVUP00000011849annotation not available (98 aa)
SOX9LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
LPGAT1acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1. (486 aa)
PRMT3Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (564 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MALRD1LOW QUALITY PROTEIN: MAM and LDL-receptor class A domain-containing protein 1. (335 aa)
MID1IP1Mid1-interacting protein 1. (183 aa)
WDTC1WD and tetratricopeptide repeats protein 1 isoform X1. (679 aa)
CLCN2Chloride channel protein. (928 aa)
LOC112912623Coiled-coil domain-containing protein 144B-like. (1459 aa)
ETFBKMTElectron transfer flavoprotein beta subunit lysine methyltransferase. (266 aa)
STARD4stAR-related lipid transfer protein 4 isoform X1. (208 aa)
DGKQDiacylglycerol kinase. (865 aa)
ADIPOQAdiponectin. (266 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
PDK1Protein-serine/threonine kinase. (407 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
PPTC7Protein phosphatase; Belongs to the PP2C family. (304 aa)
ABCD2ATP-binding cassette sub-family D member 2. (742 aa)
ABCB11Bile salt export pump. (1267 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (1111 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
NR1H4Bile acid receptor isoform X2. (481 aa)
SLC7A7Y+L amino acid transporter 1. (542 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (769 aa)
ERLIN2Erlin-2 isoform X1. (353 aa)
NR1H2Oxysterols receptor LXR-beta. (457 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (313 aa)
SLC7A11Cystine/glutamate transporter. (503 aa)
TYSND1Trypsin domain containing 1. (673 aa)
DKKL1Dickkopf-like protein 1 isoform X1. (318 aa)
APPL2DCC-interacting protein 13-beta isoform X2. (695 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1891 aa)
PANK2Pantothenate kinase 2, mitochondrial isoform X2. (449 aa)
MLXIPLCarbohydrate-responsive element-binding protein isoform X1. (907 aa)
ERLIN1Erlin-1. (346 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (555 aa)
FMO1Flavin-containing monooxygenase. (558 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
LOC112923472Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
APOA4Apolipoprotein A-IV. (388 aa)
DKK3Dickkopf-related protein 3. (357 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X1. (1133 aa)
CLN3Battenin. (438 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
NR1H3Oxysterols receptor LXR-alpha. (447 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein isoform X2. (797 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSVVUP00000037390annotation not available (101 aa)
NCOR2Nuclear receptor corepressor 2 isoform X9. (2529 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial. (555 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
ENSVVUP00000041731annotation not available (218 aa)
ABCD1ATP-binding cassette sub-family D member 1. (516 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
NCOR1Nuclear receptor corepressor 1 isoform X5. (2521 aa)
MLYCDmalonyl-CoA decarboxylase, mitochondrial. (479 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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