STRINGSTRING
EFNA1 EFNA1 FERMT2 FERMT2 BMP4 BMP4 DAG1 DAG1 TGFB1I1 TGFB1I1 PDPN PDPN IL1B IL1B MAD2L2 MAD2L2 MTOR MTOR NOTCH1 NOTCH1 SPRED1 SPRED1 GREM1 GREM1 EPHA4 EPHA4 SFRP2 SFRP2 PHLDB1 PHLDB1 BCL9L BCL9L POFUT2 POFUT2 BMP2 BMP2 SNAI1 SNAI1 USF3 USF3 TBX20 TBX20 PHLDB2 PHLDB2 FOXA1 FOXA1 NKX2-1 NKX2-1 IL17RD IL17RD SFRP1 SFRP1 GLIPR2 GLIPR2 MCRIP1 MCRIP1 TGFBR1 TGFBR1 EMP2 EMP2 LEF1 LEF1 EZH2 EZH2 VASN VASN TRIM62 TRIM62 HPN HPN SMAD3 SMAD3 SMAD4 SMAD4 LDLRAD4 LDLRAD4 SMAD7 SMAD7 SPRY2 SPRY2 SPRY1 SPRY1 ENG ENG TGFB2 TGFB2 NOG NOG ALX1 ALX1 WWTR1 WWTR1 ELL3 ELL3 PAWR PAWR CRB2 CRB2 DAB2IP DAB2IP LRG1 LRG1 TCF7L2 TCF7L2 ENSVVUP00000011174 ENSVVUP00000011174 ZNF750 ZNF750 AXIN2 AXIN2 ADIPOR1 ADIPOR1 TGFB3 TGFB3 GATA3 GATA3 CTNNB1 CTNNB1 TGFB1 TGFB1 LOXL2 LOXL2 SDHAF2 SDHAF2 POFUT2-2 POFUT2-2 DAB2 DAB2 BAMBI BAMBI PTEN PTEN IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNA1ephrin-A1 isoform X2; Belongs to the ephrin family. (205 aa)
FERMT2Fermitin family homolog 2 isoform X1. (792 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (409 aa)
DAG1Dystroglycan. (892 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Belongs to the paxillin family. (447 aa)
PDPNPodoplanin isoform X1. (169 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2644 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1 isoform X1. (443 aa)
GREM1Gremlin. (184 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
PHLDB1Pleckstrin homology-like domain family B member 1 isoform X6. (1452 aa)
BCL9LB-cell CLL/lymphoma 9-like protein. (1494 aa)
POFUT2GDP-fucose protein O-fucosyltransferase 2. (467 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SNAI1Zinc finger protein SNAI1 isoform X1. (264 aa)
USF3Basic helix-loop-helix domain-containing protein USF3. (2193 aa)
TBX20T-box transcription factor TBX20. (448 aa)
PHLDB2Pleckstrin homology-like domain family B member 2. (762 aa)
FOXA1LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha. (440 aa)
NKX2-1Homeobox protein Nkx-2.1. (369 aa)
IL17RDInterleukin-17 receptor D isoform X1. (777 aa)
SFRP1Secreted frizzled-related protein 1. (293 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. (81 aa)
MCRIP1Mapk-regulated corepressor-interacting protein 1 isoform X1. (216 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (238 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X3. (468 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X7. (751 aa)
VASNVasorin. (672 aa)
TRIM62E3 ubiquitin-protein ligase TRIM62. (475 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (460 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4. (315 aa)
SMAD7Mothers against decapentaplegic homolog. (429 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (342 aa)
ENGEndoglin. (669 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (216 aa)
ALX1ALX homeobox protein 1. (326 aa)
WWTR1WW domain-containing transcription regulator protein 1. (360 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X2. (397 aa)
PAWRPRKC apoptosis WT1 regulator protein. (292 aa)
CRB2Protein crumbs homolog 2. (1012 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1090 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (347 aa)
TCF7L2Transcription factor 7-like 2 isoform X2. (507 aa)
ENSVVUP00000011174annotation not available (238 aa)
ZNF750LOW QUALITY PROTEIN: zinc finger protein 750. (682 aa)
AXIN2Axin-2 isoform X1. (842 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
TGFB3Transforming growth factor beta-3. (412 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
LOXL2Lysyl oxidase homolog 2. (764 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (165 aa)
POFUT2-2GDP-fucose protein O-fucosyltransferase 2. (134 aa)
DAB2Disabled homolog 2 isoform X1. (873 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (369 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (207 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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