(34 nodes) Positive regulation of epithelial to mesenchymal transition network (Vulpes vulpes)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ALX1	ALX homeobox protein 1. (326 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ENG	Endoglin. (669 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	EZH2	Histone-lysine N-methyltransferase EZH2 isoform X7. (751 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X3. (468 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (238 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
	GLIPR2	Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. (81 aa)
	TBX20	T-box transcription factor TBX20. (448 aa)
	SNAI1	Zinc finger protein SNAI1 isoform X1. (264 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	BCL9L	B-cell CLL/lymphoma 9-like protein. (1494 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2644 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
	PDPN	Podoplanin isoform X1. (169 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Belongs to the paxillin family. (447 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (409 aa)
	FERMT2	Fermitin family homolog 2 isoform X1. (792 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (207 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	DAB2	Disabled homolog 2 isoform X1. (873 aa)
	LOXL2	Lysyl oxidase homolog 2. (764 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	CTNNB1	Catenin beta-1 isoform X1. (781 aa)
	TGFB3	Transforming growth factor beta-3. (412 aa)
	AXIN2	Axin-2 isoform X1. (842 aa)
	ENSVVUP00000011174	annotation not available (238 aa)
	TCF7L2	Transcription factor 7-like 2 isoform X2. (507 aa)
	LRG1	Leucine-rich alpha-2-glycoprotein. (347 aa)
	CRB2	Protein crumbs homolog 2. (1012 aa)
	WWTR1	WW domain-containing transcription regulator protein 1. (360 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSVVUP00000009241	ENSVVUP00000041694	Axin-2 isoform X1.	Bone morphogenetic protein 4 isoform X2.	0.521
AXIN2	CTNNB1	ENSVVUP00000009241	ENSVVUP00000007116	Axin-2 isoform X1.	Catenin beta-1 isoform X1.	0.995
AXIN2	ENSVVUP00000011174	ENSVVUP00000009241	ENSVVUP00000011174	Axin-2 isoform X1.	annotation not available	0.542
AXIN2	LEF1	ENSVVUP00000009241	ENSVVUP00000023803	Axin-2 isoform X1.	Lymphoid enhancer-binding factor 1 isoform X3.	0.880
AXIN2	TCF7L2	ENSVVUP00000009241	ENSVVUP00000011252	Axin-2 isoform X1.	Transcription factor 7-like 2 isoform X2.	0.542
BAMBI	BMP2	ENSVVUP00000002569	ENSVVUP00000032146	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Bone morphogenetic protein 2.	0.530
BAMBI	BMP4	ENSVVUP00000002569	ENSVVUP00000041694	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Bone morphogenetic protein 4 isoform X2.	0.526
BAMBI	SMAD3	ENSVVUP00000002569	ENSVVUP00000019777	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.622
BAMBI	SMAD4	ENSVVUP00000002569	ENSVVUP00000019738	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.656
BAMBI	TGFB1	ENSVVUP00000002569	ENSVVUP00000007028	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.707
BAMBI	TGFBR1	ENSVVUP00000002569	ENSVVUP00000026425	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.967
BCL9L	CTNNB1	ENSVVUP00000033321	ENSVVUP00000007116	B-cell CLL/lymphoma 9-like protein.	Catenin beta-1 isoform X1.	0.605
BMP2	BAMBI	ENSVVUP00000032146	ENSVVUP00000002569	Bone morphogenetic protein 2.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.530
BMP2	BMP4	ENSVVUP00000032146	ENSVVUP00000041694	Bone morphogenetic protein 2.	Bone morphogenetic protein 4 isoform X2.	0.929
BMP2	CTNNB1	ENSVVUP00000032146	ENSVVUP00000007116	Bone morphogenetic protein 2.	Catenin beta-1 isoform X1.	0.533
BMP2	IL1B	ENSVVUP00000032146	ENSVVUP00000040168	Bone morphogenetic protein 2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.440
BMP2	IL6	ENSVVUP00000032146	ENSVVUP00000001673	Bone morphogenetic protein 2.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.457
BMP2	SMAD3	ENSVVUP00000032146	ENSVVUP00000019777	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.589
BMP2	SMAD4	ENSVVUP00000032146	ENSVVUP00000019738	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.835
BMP2	TGFB1	ENSVVUP00000032146	ENSVVUP00000007028	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.455