(30 nodes) Regulation of myotube differentiation network (Vulpes vulpes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Others

textmining

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protein homology

Your Input:
	BHLHA15	Class A basic helix-loop-helix protein 15. (187 aa)
	BHLHE41	Class E basic helix-loop-helix protein 41. (520 aa)
	MYOCD	Myocardin. (978 aa)
	SMYD1	Histone-lysine N-methyltransferase SMYD1 isoform X1. (490 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
	PLPP7	Inactive phospholipid phosphatase 7. (440 aa)
	TRIM72	Tripartite motif-containing protein 72. (524 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2644 aa)
	ACTN3	Alpha-actinin-3 isoform X1. (1024 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	MAMSTR	MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X4. (427 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1180 aa)
	MAML3	LOW QUALITY PROTEIN: mastermind-like protein 3. (417 aa)
	ATP11A	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1251 aa)
	FBXO22	F-box only protein 22. (391 aa)
	MMP14	Matrix metalloproteinase-14. (582 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1146 aa)
	RBM38	RNA-binding protein 38. (239 aa)
	SIK1	Serine/threonine-protein kinase SIK1. (773 aa)
	CCN3	Protein NOV homolog. (383 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (427 aa)
	MYF6	Myogenic factor 6. (243 aa)
	TMEM119	Transmembrane protein 119. (513 aa)
	CYP26B1	Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (561 aa)
	MYOG	Myogenin. (224 aa)
	ENSVVUP00000004278	annotation not available (121 aa)
	DMPK	Myotonin-protein kinase isoform X1. (695 aa)
	NKX2-5	Homeobox protein Nkx-2.5. (322 aa)
	MAML1	Mastermind-like protein 1. (1004 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	MYF6	ENSVVUP00000036817	ENSVVUP00000014390	Alpha-actinin-3 isoform X1.	Myogenic factor 6.	0.578
ACTN3	SMYD1	ENSVVUP00000036817	ENSVVUP00000040260	Alpha-actinin-3 isoform X1.	Histone-lysine N-methyltransferase SMYD1 isoform X1.	0.415
CAV3	MYOG	ENSVVUP00000035215	ENSVVUP00000009014	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myogenin.	0.546
CAV3	TRIM72	ENSVVUP00000035215	ENSVVUP00000038972	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tripartite motif-containing protein 72.	0.708
CCN3	NOTCH1	ENSVVUP00000021531	ENSVVUP00000037241	Protein NOV homolog.	Neurogenic locus notch homolog protein 1.	0.414
HDAC4	HDAC5	ENSVVUP00000031667	ENSVVUP00000023981	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.913
HDAC4	MYOG	ENSVVUP00000031667	ENSVVUP00000009014	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Myogenin.	0.552
HDAC5	HDAC4	ENSVVUP00000023981	ENSVVUP00000031667	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.913
MAML1	NOTCH1	ENSVVUP00000001864	ENSVVUP00000037241	Mastermind-like protein 1.	Neurogenic locus notch homolog protein 1.	0.979
MAML3	NOTCH1	ENSVVUP00000029302	ENSVVUP00000037241	LOW QUALITY PROTEIN: mastermind-like protein 3.	Neurogenic locus notch homolog protein 1.	0.914
MAPK14	MYF5	ENSVVUP00000036585	ENSVVUP00000014393	Mitogen-activated protein kinase.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.415
MAPK14	MYF6	ENSVVUP00000036585	ENSVVUP00000014390	Mitogen-activated protein kinase.	Myogenic factor 6.	0.431
MAPK14	MYOG	ENSVVUP00000036585	ENSVVUP00000009014	Mitogen-activated protein kinase.	Myogenin.	0.442
MYF5	MAPK14	ENSVVUP00000014393	ENSVVUP00000036585	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Mitogen-activated protein kinase.	0.415
MYF5	MYF6	ENSVVUP00000014393	ENSVVUP00000014390	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myogenic factor 6.	0.705
MYF5	MYOG	ENSVVUP00000014393	ENSVVUP00000009014	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myogenin.	0.695
MYF6	ACTN3	ENSVVUP00000014390	ENSVVUP00000036817	Myogenic factor 6.	Alpha-actinin-3 isoform X1.	0.578
MYF6	MAPK14	ENSVVUP00000014390	ENSVVUP00000036585	Myogenic factor 6.	Mitogen-activated protein kinase.	0.431
MYF6	MYF5	ENSVVUP00000014390	ENSVVUP00000014393	Myogenic factor 6.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.705
MYF6	MYOG	ENSVVUP00000014390	ENSVVUP00000009014	Myogenic factor 6.	Myogenin.	0.646