90 items (Vulpes vulpes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEPR	Leptin receptor isoform X1. (1172 aa)
	TMEM130	Transmembrane protein 130 isoform X1. (435 aa)
	APOB	Apolipoprotein B-100. (4347 aa)
	CYB5R3	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (302 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (303 aa)
	AKR1D1	3-oxo-5-beta-steroid 4-dehydrogenase. (302 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
	NFE2L1	Endoplasmic reticulum membrane sensor NFE2L1 isoform X1. (781 aa)
	DHCR7	7-dehydrocholesterol reductase. (475 aa)
	GBA	Glucosylceramidase. (564 aa)
	FDPS	Farnesyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family. (486 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (400 aa)
	CUBN	Cubilin. (3627 aa)
	NPC2	NPC intracellular cholesterol transporter 2 isoform X1. (149 aa)
	NSDHL	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating isoform X2; Belongs to the 3-beta-HSD family. (361 aa)
	ENSVVUP00000008159	annotation not available (281 aa)
	SREBF1	Sterol regulatory element-binding protein 1 isoform X3. (1152 aa)
	EBP	3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase. (228 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (606 aa)
	CYP39A1	24-hydroxycholesterol 7-alpha-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (534 aa)
	CYP46A1	Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (500 aa)
	SOAT2	O-acyltransferase. (524 aa)
	LOC112927104	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (275 aa)
	TM7SF2	Delta(14)-sterol reductase isoform X1. (432 aa)
	ABCA1	ATP-binding cassette sub-family A member 1. (2230 aa)
	CDCP2	CUB domain-containing protein 2. (413 aa)
	DHCR24	Delta(24)-sterol reductase. (516 aa)
	ANGPTL3	Angiopoietin-related protein 3. (459 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (486 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	APOA4	Apolipoprotein A-IV. (388 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (933 aa)
	APOA1	Apolipoprotein A-I. (266 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)
	TSKU	Tsukushin. (357 aa)
	CLN8	Protein CLN8. (288 aa)
	VLDLR	Very low-density lipoprotein receptor. (868 aa)
	CYB5R1	NADH-cytochrome b5 reductase 1. (396 aa)
	ARV1	Protein ARV1. (281 aa)
	CYP26B1	Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (561 aa)
	APOE	Apolipoprotein E. (336 aa)
	ENSVVUP00000011619	annotation not available (275 aa)
	ENSVVUP00000012461	annotation not available (356 aa)
	LIPE	Hormone-sensitive lipase. (755 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1630 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (542 aa)
	HSD17B7	3-keto-steroid reductase isoform X1. (403 aa)
	FDXR	NADPH:adrenodoxin oxidoreductase, mitochondrial. (492 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1493 aa)
	LSS	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (749 aa)
	HDLBP	Vigilin. (1307 aa)
	CH25H	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (295 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (487 aa)
	LOC112911200	Cytochrome P450 11B1, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (602 aa)
	ENSVVUP00000030976	annotation not available (140 aa)
	MSMO1	Methylsterol monooxygenase 1 isoform X2; Belongs to the sterol desaturase family. (295 aa)
	GBA2	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (925 aa)
	CYP26A1	LOW QUALITY PROTEIN: cytochrome P450 26A1; Belongs to the cytochrome P450 family. (495 aa)
	CYP26C1	Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (522 aa)
	MT3	Metallothionein 3. (68 aa)
	HNF1A	Hepatocyte nuclear factor 1-alpha isoform X1. (661 aa)
	SC5D	Lathosterol oxidase; Belongs to the sterol desaturase family. (299 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (339 aa)
	ERLIN2	Erlin-2 isoform X1. (353 aa)
	CYP1A2	Cytochrome P450 1A2 isoform X2; Belongs to the cytochrome P450 family. (512 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (551 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
	LDLR	Low-density lipoprotein receptor. (866 aa)
	SQLE	Squalene monooxygenase. (573 aa)
	ABCG1	ATP-binding cassette sub-family G member 1 isoform X1. (656 aa)
	APOA2	Apolipoprotein A-II. (100 aa)
	ENSVVUP00000014375	annotation not available (293 aa)
	ENSVVUP00000014713	annotation not available (199 aa)
	LOC112912510	3-oxo-5-beta-steroid 4-dehydrogenase-like. (317 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	SOAT1	O-acyltransferase. (549 aa)
	MBTPS2	Membrane-bound transcription factor site-2 protease isoform X1. (528 aa)
	CCDC160	Coiled-coil domain-containing protein 160. (323 aa)
	CYP51A1	Lanosterol 14-alpha demethylase isoform X1; Belongs to the cytochrome P450 family. (511 aa)
	CLN6	Ceroid-lipofuscinosis neuronal protein 6. (316 aa)
	LBR	lamin-B receptor. (617 aa)
	FDFT1	Squalene synthase isoform X1. (484 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	SCAP	Sterol regulatory element-binding protein cleavage-activating protein. (1161 aa)
	LIPC	Hepatic triacylglycerol lipase. (501 aa)
	CYP27A1	Sterol 26-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (530 aa)
	ENSVVUP00000000015	annotation not available (175 aa)
	PON1	Serum paraoxonase/arylesterase 1. (355 aa)
	FDX1	Adrenodoxin, mitochondrial. (227 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA1	ENSVVUP00000038260	ENSVVUP00000034996	ATP-binding cassette sub-family A member 1.	Apolipoprotein A-I.	0.933
ABCA1	APOA2	ENSVVUP00000038260	ENSVVUP00000021456	ATP-binding cassette sub-family A member 1.	Apolipoprotein A-II.	0.516
ABCA1	APOB	ENSVVUP00000038260	ENSVVUP00000020128	ATP-binding cassette sub-family A member 1.	Apolipoprotein B-100.	0.603
ABCA1	APOE	ENSVVUP00000038260	ENSVVUP00000011276	ATP-binding cassette sub-family A member 1.	Apolipoprotein E.	0.757
ABCA1	CYP27A1	ENSVVUP00000038260	ENSVVUP00000001296	ATP-binding cassette sub-family A member 1.	Sterol 26-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	0.516
ABCA1	CYP46A1	ENSVVUP00000038260	ENSVVUP00000039839	ATP-binding cassette sub-family A member 1.	Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family.	0.466
ABCA1	CYP7A1	ENSVVUP00000038260	ENSVVUP00000024435	ATP-binding cassette sub-family A member 1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.525
ABCA1	DHCR24	ENSVVUP00000038260	ENSVVUP00000037438	ATP-binding cassette sub-family A member 1.	Delta(24)-sterol reductase.	0.405
ABCA1	HMGCR	ENSVVUP00000038260	ENSVVUP00000034999	ATP-binding cassette sub-family A member 1.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.607
ABCA1	HMGCS1	ENSVVUP00000038260	ENSVVUP00000035290	ATP-binding cassette sub-family A member 1.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.436
ABCA1	LIPC	ENSVVUP00000038260	ENSVVUP00000001665	ATP-binding cassette sub-family A member 1.	Hepatic triacylglycerol lipase.	0.517
ABCA1	SCARB1	ENSVVUP00000038260	ENSVVUP00000035965	ATP-binding cassette sub-family A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.741
ABCA1	SREBF1	ENSVVUP00000038260	ENSVVUP00000042447	ATP-binding cassette sub-family A member 1.	Sterol regulatory element-binding protein 1 isoform X3.	0.442
ABCA1	VLDLR	ENSVVUP00000038260	ENSVVUP00000008403	ATP-binding cassette sub-family A member 1.	Very low-density lipoprotein receptor.	0.453
ABCG1	APOB	ENSVVUP00000022700	ENSVVUP00000020128	ATP-binding cassette sub-family G member 1 isoform X1.	Apolipoprotein B-100.	0.520
ABCG1	APOE	ENSVVUP00000022700	ENSVVUP00000011276	ATP-binding cassette sub-family G member 1 isoform X1.	Apolipoprotein E.	0.700
ABCG1	CYP27A1	ENSVVUP00000022700	ENSVVUP00000001296	ATP-binding cassette sub-family G member 1 isoform X1.	Sterol 26-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	0.487
ABCG1	CYP46A1	ENSVVUP00000022700	ENSVVUP00000039839	ATP-binding cassette sub-family G member 1 isoform X1.	Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family.	0.510
ABCG1	CYP7A1	ENSVVUP00000022700	ENSVVUP00000024435	ATP-binding cassette sub-family G member 1 isoform X1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.537
ABCG1	HMGCR	ENSVVUP00000022700	ENSVVUP00000034999	ATP-binding cassette sub-family G member 1 isoform X1.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.603