STRINGSTRING
PHACTR4 PHACTR4 KDF1 KDF1 MKS1 MKS1 KDM6A KDM6A NOG NOG SOX8 SOX8 COBL COBL LHX2 LHX2 SOX9 SOX9 PDX1 PDX1 DVL3 DVL3 TRAF6 TRAF6 MED12 MED12 GATA3 GATA3 MTHFD1L MTHFD1L RALA RALA JAG2 JAG2 WNT9B WNT9B HAND1 HAND1 DVL1 DVL1 TFAP2A TFAP2A SUFU SUFU GRSF1 GRSF1 VASP VASP MIB1 MIB1 SPINT2-2 SPINT2-2 SETD2 SETD2 FZD3 FZD3 SOX4 SOX4 GDNF GDNF ALDH1A2 ALDH1A2 LRRC1 LRRC1 WNT6 WNT6 MPP5 MPP5 ARHGAP35 ARHGAP35 LMO4 LMO4 HS2ST1 HS2ST1 BCL10 BCL10 PRKACB PRKACB HECTD1 HECTD1 BMP4 BMP4 HIF1A HIF1A TGFB1I1 TGFB1I1 SEMA4C SEMA4C PCDH8 PCDH8 PAX8 PAX8 SALL4 SALL4 PTK7 PTK7 MTHFR MTHFR TSC1 TSC1 RARG RARG MTHFD1 MTHFD1 DVL2 DVL2 ABL1 ABL1 HES5 HES5 GRHL3 GRHL3 LUZP1 LUZP1 SPINT1 SPINT1 GREM1 GREM1 SHANK3 SHANK3 PLXNB2 PLXNB2 FGF10 FGF10 ENSVVUP00000035204 ENSVVUP00000035204 BRD2 BRD2 SFRP2 SFRP2 CELSR1 CELSR1 OPA1 OPA1 SHROOM3 SHROOM3 PTCH1 PTCH1 TEAD2 TEAD2 SCRIB SCRIB CECR2 CECR2 IRX2 IRX2 TRIM71 TRIM71 IFT57 IFT57 NODAL NODAL FUZ FUZ RET RET KAT2A KAT2A GLMN GLMN SFRP1 SFRP1 ST14 ST14 IRX3 IRX3 IFT52 IFT52 RDH10 RDH10 STK4 STK4 BBS4 BBS4 TULP3 TULP3 FZD2 FZD2 SEC24B SEC24B CTHRC1 CTHRC1 PRICKLE1 PRICKLE1 LRP2 LRP2 KDM2B KDM2B TCTN1 TCTN1 CLUAP1 CLUAP1 CC2D2A CC2D2A ENSVVUP00000020138 ENSVVUP00000020138 OSR1 OSR1 LIAS LIAS ALDH1A3 ALDH1A3 LOC112922441 LOC112922441 ENSVVUP00000019188 ENSVVUP00000019188 TP63 TP63 SPINT2 SPINT2 VEGFC VEGFC LOC112916859 LOC112916859 STK3 STK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHACTR4Phosphatase and actin regulator. (857 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
MKS1Meckel syndrome type 1 protein isoform X1. (580 aa)
KDM6ALysine-specific demethylase 6A isoform X1. (1453 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (216 aa)
SOX8Transcription factor SOX-8. (480 aa)
COBLProtein cordon-bleu isoform X3. (1287 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
SOX9LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
PDX1Pancreas/duodenum homeobox protein 1. (282 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X2. (747 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2064 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. (728 aa)
RALARas-related protein Ral-A. (206 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1215 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
TFAP2ATranscription factor AP-2-alpha isoform X1. (439 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
GRSF1G-rich sequence factor 1. (344 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (350 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1006 aa)
SPINT2-2Kunitz-type protease inhibitor 2 isoform X1. (74 aa)
SETD2Histone-lysine N-methyltransferase SETD2. (2543 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SOX4Transcription factor SOX-4. (170 aa)
GDNFGlial cell line-derived neurotrophic factor. (198 aa)
ALDH1A2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
LRRC1Leucine-rich repeat-containing protein 1 isoform X1. (619 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
MPP5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
ARHGAP35Rho GTPase-activating protein 35. (1516 aa)
LMO4LIM domain transcription factor LMO4. (165 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1 isoform X2. (356 aa)
BCL10B-cell lymphoma/leukemia 10. (235 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
HECTD1E3 ubiquitin-protein ligase HECTD1 isoform X1. (2610 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (409 aa)
HIF1AHypoxia-inducible factor 1-alpha. (764 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Belongs to the paxillin family. (447 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
PCDH8LOW QUALITY PROTEIN: protocadherin-8. (973 aa)
PAX8Paired box protein Pax-8 isoform X3. (459 aa)
SALL4LOW QUALITY PROTEIN: sal-like protein 4. (267 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
TSC1Hamartin isoform X1. (1168 aa)
RARGRetinoic acid receptor gamma isoform X1. (648 aa)
MTHFD1C-1-tetrahydrofolate synthase, cytoplasmic. (496 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X4. (732 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
HES5Transcription factor HES-5. (139 aa)
GRHL3Grainyhead-like protein 3 homolog. (606 aa)
LUZP1Leucine zipper protein 1. (1109 aa)
SPINT1Kunitz-type protease inhibitor 1. (595 aa)
GREM1Gremlin. (184 aa)
SHANK3LOW QUALITY PROTEIN: SH3 and multiple ankyrin repeat domains protein 3. (1667 aa)
PLXNB2plexin-B2. (1887 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
ENSVVUP00000035204annotation not available (500 aa)
BRD2Bromodomain-containing protein 2. (803 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2741 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (998 aa)
SHROOM3LOW QUALITY PROTEIN: protein Shroom3. (1852 aa)
PTCH1Protein patched homolog 1 isoform X3. (1386 aa)
TEAD2Transcriptional enhancer factor TEF-4. (437 aa)
SCRIBProtein scribble homolog. (1517 aa)
CECR2Cat eye syndrome critical region protein 2 isoform X3. (1300 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (346 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (566 aa)
IFT57Intraflagellar transport protein 57 homolog. (429 aa)
NODALNodal homolog isoform X1. (348 aa)
FUZProtein fuzzy homolog isoform X1. (419 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1070 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (903 aa)
GLMNGlomulin. (550 aa)
SFRP1Secreted frizzled-related protein 1. (293 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (832 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (538 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (446 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (494 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X1. (520 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (643 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (567 aa)
SEC24BLOW QUALITY PROTEIN: protein transport protein Sec24B. (1250 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (247 aa)
PRICKLE1Prickle-like protein 1. (832 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4329 aa)
KDM2BLysine-specific demethylase 2B isoform X4. (1491 aa)
TCTN1Tectonic-1 isoform X1. (589 aa)
CLUAP1Clusterin-associated protein 1 isoform X1. (507 aa)
CC2D2ACoiled-coil and C2 domain-containing protein 2A isoform X1. (1531 aa)
ENSVVUP00000020138annotation not available (464 aa)
OSR1LOW QUALITY PROTEIN: protein odd-skipped-related 1. (294 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
ALDH1A3Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
LOC112922441LOW QUALITY PROTEIN: C-1-tetrahydrofolate synthase, cytoplasmic-like. (792 aa)
ENSVVUP00000019188annotation not available (143 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (676 aa)
SPINT2Kunitz-type protease inhibitor 2 isoform X1. (248 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
LOC112916859LOW QUALITY PROTEIN: sal-like protein 4. (138 aa)
STK3Serine/threonine-protein kinase 3. (508 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.