STRINGSTRING
CYP27A1 CYP27A1 AKR1D1 AKR1D1 COQ6 COQ6 MICAL1 MICAL1 CYP26B1 CYP26B1 FMO5 FMO5 LOC112933725 LOC112933725 NOS3 NOS3 LOC112914568 LOC112914568 LOC112912510 LOC112912510 NOS1 NOS1 CYP51A1 CYP51A1 NOS2 NOS2 CYP27B1 CYP27B1 SQLE SQLE CYP7A1 CYP7A1 COQ7 COQ7 CYP26A1 CYP26A1 MICAL3 MICAL3 FMO4 FMO4 FMO1 FMO1 FMO2 FMO2 LOC112923472 LOC112923472 FMO3 FMO3 MICAL2 MICAL2 KMO KMO CYP46A1 CYP46A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP27A1Sterol 26-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (530 aa)
AKR1D13-oxo-5-beta-steroid 4-dehydrogenase. (302 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (481 aa)
MICAL1F-actin-monooxygenase MICAL1. (1115 aa)
CYP26B1Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (561 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
LOC112933725Aldo-keto reductase family 1 member C1 homolog isoform X1. (324 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1207 aa)
LOC112914568Dimethylaniline monooxygenase [N-oxide-forming]. (617 aa)
LOC1129125103-oxo-5-beta-steroid 4-dehydrogenase-like. (317 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
CYP51A1Lanosterol 14-alpha demethylase isoform X1; Belongs to the cytochrome P450 family. (511 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
SQLESqualene monooxygenase. (573 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (281 aa)
CYP26A1LOW QUALITY PROTEIN: cytochrome P450 26A1; Belongs to the cytochrome P450 family. (495 aa)
MICAL3F-actin-monooxygenase MICAL3 isoform X4. (2164 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (555 aa)
FMO1Flavin-containing monooxygenase. (558 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
LOC112923472Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
MICAL2F-actin-monooxygenase MICAL2 isoform X5. (1782 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
CYP46A1Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (500 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.