STRINGSTRING
HYAL3 HYAL3 ATP13A2 ATP13A2 RAB15 RAB15 CSPG5 CSPG5 ADCY1 ADCY1 RAB24 RAB24 RAB5A RAB5A RAB27A RAB27A FOXF1 FOXF1 STXBP3 STXBP3 FBXL20 FBXL20 BRAF BRAF PRKN PRKN PRKN-2 PRKN-2 VAMP8 VAMP8 NLGN1 NLGN1 BLK BLK PLA2G3 PLA2G3 SYT8 SYT8 TSG101 TSG101 VAMP7 VAMP7 ANXA1 ANXA1 CHMP2A CHMP2A GIPC3 GIPC3 DTNBP1 DTNBP1 SNF8 SNF8 ENSVVUP00000004697 ENSVVUP00000004697 CACNB2 CACNB2 STAM STAM APBA1 APBA1 DVL1 DVL1 SYTL4 SYTL4 RAB3B RAB3B TPCN2 TPCN2 SYT7 SYT7 STXBP5 STXBP5 PREPL PREPL ENSVVUP00000007085 ENSVVUP00000007085 PRKCB PRKCB RALA RALA SYT11 SYT11 MICAL1 MICAL1 REST REST LGI3 LGI3 CHRM2 CHRM2 FES FES SYT2 SYT2 DGKI DGKI SYT5 SYT5 SNX4 SNX4 SYT6 SYT6 CHRNA5 CHRNA5 ADRA2C ADRA2C RAB3A RAB3A CDK5 CDK5 RAB9A RAB9A PDPK1 PDPK1 CD177 CD177 RAB26 RAB26 SYT1 SYT1 LOC112920766 LOC112920766 CNR1 CNR1 RAP1B RAP1B LOC112924172 LOC112924172 CFTR CFTR RPH3A RPH3A SYT12 SYT12 PFN2 PFN2 BAIAP3 BAIAP3 CACNA1H CACNA1H RAB8B RAB8B RAB12 RAB12 CADPS2 CADPS2 FGR FGR IL1RAPL1 IL1RAPL1 SEPTIN4-2 SEPTIN4-2 SYT10 SYT10 SYT3 SYT3 STXBP1 STXBP1 DNM1 DNM1 LAMP1 LAMP1 CACNA1I CACNA1I RAPGEF4 RAPGEF4 CACNB4 CACNB4 SYNPR SYNPR CADPS CADPS SDC1 SDC1 RAB27B RAB27B UNC13D UNC13D EXPH5 EXPH5 LOC112925884 LOC112925884 RAB10 RAB10 CD84 CD84 LOC112916044 LOC112916044 RAP1A RAP1A LOC112934124 LOC112934124 LRRK2 LRRK2 P2RX7 P2RX7 RIMS2 RIMS2 VPS4A VPS4A KIAA0100 KIAA0100 ENSVVUP00000023383 ENSVVUP00000023383 RAB8A RAB8A VPS4B VPS4B LYN LYN SYP SYP CUNH12orf4 CUNH12orf4 SCAMP5 SCAMP5 RAB8A-2 RAB8A-2 GRIN3A GRIN3A BCR BCR PCLO PCLO HGS HGS SYT17 SYT17 GIT1 GIT1 RAB33B RAB33B RPH3AL RPH3AL DOC2B DOC2B RAB3C RAB3C GSK3B GSK3B SYK SYK STXBP5L STXBP5L ATP9A ATP9A SEPTIN2 SEPTIN2 CBARP CBARP SPHK2 SPHK2 RAB3D RAB3D NCKAP1L NCKAP1L RAC2 RAC2 ZP3 ZP3 IL4 IL4 IL13 IL13 BACE1 BACE1 ENSVVUP00000034315 ENSVVUP00000034315 STX1A STX1A PRAM1 PRAM1 FGB FGB F2RL1 F2RL1 SEPTIN5 SEPTIN5 SYT15 SYT15 CACNA1A CACNA1A DOC2A DOC2A SEPTIN1 SEPTIN1 ENSVVUP00000036810 ENSVVUP00000036810 NOTCH1 NOTCH1 VPS18 VPS18 CACNA1A-2 CACNA1A-2 GIPC1 GIPC1 SYT13 SYT13 STX1B STX1B SLC4A8 SLC4A8 SYT4 SYT4 SYT9 SYT9 SNAPIN SNAPIN CACNA1B CACNA1B RAB13 RAB13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HYAL3Hyaluronidase. (489 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1118 aa)
RAB15Ras-related protein Rab-15. (204 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (543 aa)
ADCY1Adenylate cyclase type 1-like. (919 aa)
RAB24Ras-related protein Rab-24 isoform X1. (203 aa)
RAB5ARas-related protein Rab-5A. (215 aa)
RAB27ARas-related protein Rab-27A. (221 aa)
FOXF1Forkhead box protein F1. (354 aa)
STXBP3Syntaxin-binding protein 3 isoform X4; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
FBXL20F-box/LRR-repeat protein 20 isoform X1. (438 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (765 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (381 aa)
PRKN-2E3 ubiquitin-protein ligase parkin. (176 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
NLGN1Neuroligin-1 isoform X1. (502 aa)
BLKTyrosine-protein kinase. (500 aa)
PLA2G3LOW QUALITY PROTEIN: group 3 secretory phospholipase A2. (512 aa)
SYT8Synaptotagmin-8. (402 aa)
TSG101LOW QUALITY PROTEIN: tumor susceptibility gene 101 protein. (373 aa)
VAMP7Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family. (224 aa)
ANXA1Annexin. (345 aa)
CHMP2ACharged multivesicular body protein 2a isoform X2. (222 aa)
GIPC3PDZ domain-containing protein GIPC3. (314 aa)
DTNBP1Dysbindin. (360 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
ENSVVUP00000004697annotation not available (107 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X4. (610 aa)
STAMSignal transducing adapter molecule 1 isoform X1. (538 aa)
APBA1LOW QUALITY PROTEIN: amyloid-beta A4 precursor protein-binding family A member 1. (791 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
SYTL4Synaptotagmin-like protein 4 isoform X1. (671 aa)
RAB3BRas-related protein Rab-3B. (243 aa)
TPCN2Two pore calcium channel protein 2. (696 aa)
SYT7Synaptotagmin-7. (681 aa)
STXBP5Syntaxin-binding protein 5 isoform X1. (1179 aa)
PREPLProlyl endopeptidase-like isoform X1. (727 aa)
ENSVVUP00000007085annotation not available (499 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
RALARas-related protein Ral-A. (206 aa)
SYT11Synaptotagmin-11. (431 aa)
MICAL1F-actin-monooxygenase MICAL1. (1115 aa)
RESTRE1-silencing transcription factor. (996 aa)
LGI3Leucine-rich repeat LGI family member 3. (550 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (503 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (852 aa)
SYT2Synaptotagmin-2. (419 aa)
DGKIDiacylglycerol kinase. (1008 aa)
SYT5Synaptotagmin-5. (386 aa)
SNX4Sorting nexin-4. (412 aa)
SYT6Synaptotagmin-6 isoform X2. (421 aa)
CHRNA5Neuronal acetylcholine receptor subunit alpha-5 isoform X1. (498 aa)
ADRA2Calpha-2C adrenergic receptor. (297 aa)
RAB3ARas-related protein Rab-3A. (224 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X3; Belongs to the protein kinase superfamily. (383 aa)
RAB9ARas-related protein Rab-9A. (201 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
CD177CD177 antigen. (412 aa)
RAB26Ras-related protein Rab-26 isoform X3. (190 aa)
SYT1Synaptotagmin-1 isoform X1. (454 aa)
LOC112920766CMRF35-like molecule 8 isoform X1. (312 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
LOC112924172Double C2-like domain-containing protein. (387 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1493 aa)
RPH3Arabphilin-3A. (685 aa)
SYT12Synaptotagmin-12. (421 aa)
PFN2Profilin; Belongs to the profilin family. (142 aa)
BAIAP3BAI1-associated protein 3 isoform X5. (1192 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H. (2324 aa)
RAB8BRas-related protein Rab-8B. (207 aa)
RAB12Ras-related protein Rab-12. (222 aa)
CADPS2Calcium-dependent secretion activator 2 isoform X7. (1337 aa)
FGRTyrosine-protein kinase. (527 aa)
IL1RAPL1Interleukin-1 receptor accessory protein-like 1. (407 aa)
SEPTIN4-2Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (465 aa)
SYT10Synaptotagmin 10. (385 aa)
SYT3Synaptotagmin-3. (591 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (597 aa)
DNM1Dynamin-1 isoform X9; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (845 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (420 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2127 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X2. (1037 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (486 aa)
SYNPRSynaptoporin isoform X1. (309 aa)
CADPSLOW QUALITY PROTEIN: calcium-dependent secretion activator 1. (1251 aa)
SDC1Syndecan 1. (322 aa)
RAB27BRas-related protein Rab-27B. (260 aa)
UNC13DProtein unc-13 homolog D. (1091 aa)
EXPH5Exophilin-5 isoform X1. (2087 aa)
LOC112925884Ras-related protein Rab-13-like. (189 aa)
RAB10Ras-related protein Rab-10. (200 aa)
CD84SLAM family member 5. (340 aa)
LOC112916044Synaptotagmin-17-like. (392 aa)
RAP1ARas-related protein Rap-1A. (336 aa)
LOC112934124Rab5 GDP/GTP exchange factor isoform X1. (800 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
RIMS2Regulating synaptic membrane exocytosis protein 2 isoform X1. (1674 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (518 aa)
KIAA0100Protein KIAA0100 homolog isoform X1. (2330 aa)
ENSVVUP00000023383annotation not available (202 aa)
RAB8ARas-related protein Rab-8A. (218 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (461 aa)
LYNTyrosine-protein kinase. (512 aa)
SYPSynaptophysin. (318 aa)
CUNH12orf4Protein C12orf4 homolog isoform X1. (554 aa)
SCAMP5Secretory carrier-associated membrane protein. (253 aa)
RAB8A-2Ras-related protein Rab-8A. (210 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A isoform X1. (243 aa)
BCRBreakpoint cluster region protein. (1367 aa)
PCLOProtein piccolo. (5036 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (716 aa)
SYT17Synaptotagmin-17. (474 aa)
GIT1ARF GTPase-activating protein GIT1. (798 aa)
RAB33BRas-related protein Rab-33B. (225 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (325 aa)
DOC2BDouble C2-like domain-containing protein beta. (363 aa)
RAB3CRas-related protein Rab-3C isoform X1. (227 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (459 aa)
SYKTyrosine-protein kinase. (610 aa)
STXBP5LSyntaxin-binding protein 5-like isoform X1. (1237 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1102 aa)
SEPTIN2Septin-2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (361 aa)
CBARPVoltage-dependent calcium channel beta subunit-associated regulatory protein. (507 aa)
SPHK2Sphingosine kinase 2 isoform X1. (674 aa)
RAB3DRas-related protein Rab-3D. (219 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1133 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (173 aa)
ZP3Zona pellucida sperm-binding protein 3. (426 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
IL13Interleukin-13. (131 aa)
BACE1Beta-secretase 1 isoform X1; Belongs to the peptidase A1 family. (501 aa)
ENSVVUP00000034315annotation not available (59 aa)
STX1Asyntaxin-1A; Belongs to the syntaxin family. (308 aa)
PRAM1PML-RARA-regulated adapter molecule 1. (645 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
F2RL1Proteinase-activated receptor 2. (394 aa)
SEPTIN5Septin-5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (448 aa)
SYT15Synaptotagmin-15. (551 aa)
CACNA1ACalcium voltage-gated channel subunit alpha1 A. (1545 aa)
DOC2ADouble C2-like domain-containing protein alpha isoform X3. (424 aa)
SEPTIN1Septin-1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (375 aa)
ENSVVUP00000036810annotation not available (68 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2644 aa)
VPS18Vacuolar protein sorting-associated protein 18 homolog. (973 aa)
CACNA1A-2Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (296 aa)
GIPC1PDZ domain-containing protein GIPC1. (417 aa)
SYT13Synaptotagmin-13. (426 aa)
STX1Bsyntaxin-1B; Belongs to the syntaxin family. (294 aa)
SLC4A8Anion exchange protein. (1081 aa)
SYT4Synaptotagmin-4. (472 aa)
SYT9Synaptotagmin-9. (501 aa)
SNAPINSNARE-associated protein Snapin. (82 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2243 aa)
RAB13Ras-related protein Rab-13 isoform X1. (188 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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