STRINGSTRING
PML PML SEMA4G SEMA4G PSRC1 PSRC1 CDHR2 CDHR2 OSGIN2 OSGIN2 ADAM15 ADAM15 RACK1 RACK1 ENPP1 ENPP1 SLIT3 SLIT3 CDKN1C CDKN1C ENSVVUP00000004395 ENSVVUP00000004395 PHB PHB SEMA4F SEMA4F ULK1 ULK1 MINAR1 MINAR1 PPP1R9B PPP1R9B RERG RERG LOC112922133 LOC112922133 CDKN1B CDKN1B SMARCA2 SMARCA2 WNT3 WNT3 CCAR2 CCAR2 TGFB1 TGFB1 C10orf90 C10orf90 RYK RYK SERTAD3 SERTAD3 ENSVVUP00000007731 ENSVVUP00000007731 SERTAD1 SERTAD1 SEMA4A SEMA4A CDKN2C CDKN2C INHBA INHBA SEMA4B SEMA4B YJEFN3 YJEFN3 NDUFA13 NDUFA13 CDK5 CDK5 ENSVVUP00000011482 ENSVVUP00000011482 SEMA6B SEMA6B GNG4 GNG4 RTN4 RTN4 GSK3A GSK3A ST7 ST7 CYP27C1 CYP27C1 TSPYL2 TSPYL2 DDX3X DDX3X CRLF3 CRLF3 SESN2 SESN2 SEMA6C SEMA6C TGFB2 TGFB2 CDKN2AIP CDKN2AIP SLIT2 SLIT2 BCL6 BCL6 NAIF1 NAIF1 PTPRS PTPRS OSTN OSTN TNR TNR ENSVVUP00000019211 ENSVVUP00000019211 ENSVVUP00000019282 ENSVVUP00000019282 ENSVVUP00000019285 ENSVVUP00000019285 GJA1 GJA1 RBBP7 RBBP7 SEMA6D SEMA6D SMAD4 SMAD4 SMAD3 SMAD3 MSX1 MSX1 CCN3 CCN3 ST7L ST7L SEMA7A SEMA7A MYL2 MYL2 WT1 WT1 FRZB FRZB CYP27B1 CYP27B1 DCSTAMP DCSTAMP CDKN2D CDKN2D SEMA5A SEMA5A FHL1 FHL1 GDF9 GDF9 SEMA3E SEMA3E WNT11 WNT11 ENSVVUP00000033251 ENSVVUP00000033251 SERPINE2 SERPINE2 MYL10 MYL10 NDUFS3 NDUFS3 DCUN1D3 DCUN1D3 SPHK2 SPHK2 PTPRJ PTPRJ CIRBP CIRBP STK11 STK11 FBP1 FBP1 SEMA5B SEMA5B EAF2 EAF2 SEMA4D SEMA4D MT3 MT3 MYL2-2 MYL2-2 DCBLD2 DCBLD2 FSTL4 FSTL4 CDKL3 CDKL3 SFRP1 SFRP1 SIRT1 SIRT1 SEMA3C SEMA3C SEMA6A SEMA6A HNF4A HNF4A SEMA3A SEMA3A SEMA3D SEMA3D TP53TG5 TP53TG5 NME6 NME6 CGRRF1 CGRRF1 PLXNA3 PLXNA3 MUL1 MUL1 IP6K2 IP6K2 NTN1 NTN1 SEMA4C SEMA4C SEMA3F SEMA3F DRAXIN DRAXIN SEMA3B SEMA3B IFRD2 IFRD2 HYAL1 HYAL1 HYAL2 HYAL2 RB1 RB1 TP53 TP53 ACVR1B ACVR1B SFRP2 SFRP2 ACVRL1 ACVRL1 BMP10 BMP10 SPART SPART PI16 PI16 CDKN1A CDKN1A SEMA3G SEMA3G GDF2 GDF2 DIP2B DIP2B DNAJB2 DNAJB2 RTN4R RTN4R SH3BP4 SH3BP4 WNT3A WNT3A DDX3Y DDX3Y OSGIN1 OSGIN1 FLCN FLCN SOX17 SOX17 SMARCA4 SMARCA4 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PMLProtein PML. (406 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (840 aa)
PSRC1Proline/serine-rich coiled-coil protein 1 isoform X1. (364 aa)
CDHR2Cadherin-related family member 2. (887 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2. (503 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (866 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (932 aa)
SLIT3Slit homolog 3 protein. (1372 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (165 aa)
ENSVVUP00000004395annotation not available (210 aa)
PHBProhibitin. (270 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (964 aa)
ULK1Serine/threonine-protein kinase ULK1. (995 aa)
MINAR1Major intrinsically disordered Notch2-binding receptor 1. (917 aa)
PPP1R9BNeurabin-2. (776 aa)
RERGRas-related and estrogen-regulated growth inhibitor. (199 aa)
LOC112922133Probable global transcription activator SNF2L2. (263 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
SMARCA2Probable global transcription activator SNF2L2. (1177 aa)
WNT3Wingless-type MMTV integration site family, member 3. (170 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (918 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
C10orf90Centrosomal protein C10orf90 homolog isoform X1. (807 aa)
RYKTyrosine-protein kinase RYK. (546 aa)
SERTAD3SERTA domain-containing protein 3. (213 aa)
ENSVVUP00000007731annotation not available (190 aa)
SERTAD1SERTA domain-containing protein 1. (237 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (585 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
INHBAInhibin beta A chain. (424 aa)
SEMA4Bsemaphorin-4B; Belongs to the semaphorin family. (954 aa)
YJEFN3yjeF N-terminal domain-containing protein 3 isoform X2. (345 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (218 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X3; Belongs to the protein kinase superfamily. (383 aa)
ENSVVUP00000011482annotation not available (162 aa)
SEMA6BLOW QUALITY PROTEIN: semaphorin-6B; Belongs to the semaphorin family. (685 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
RTN4Reticulon. (993 aa)
GSK3AGlycogen synthase kinase-3 alpha. (446 aa)
ST7Suppressor of tumorigenicity 7 protein isoform X3. (511 aa)
CYP27C1Cytochrome P450 27C1 isoform X2; Belongs to the cytochrome P450 family. (492 aa)
TSPYL2Testis-specific Y-encoded-like protein 2 isoform X1; Belongs to the nucleosome assembly protein (NAP) family. (725 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
CRLF3Cytokine receptor-like factor 3. (400 aa)
SESN2Sestrin-2. (484 aa)
SEMA6CLOW QUALITY PROTEIN: semaphorin-6C; Belongs to the semaphorin family. (940 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CDKN2AIPCDKN2A-interacting protein isoform X1. (580 aa)
SLIT2Slit homolog 2 protein. (1329 aa)
BCL6B-cell lymphoma 6 protein. (721 aa)
NAIF1Nuclear apoptosis-inducing factor 1. (327 aa)
PTPRSLOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase S. (1947 aa)
OSTNOsteocrin. (151 aa)
TNRtenascin-R. (1356 aa)
ENSVVUP00000019211annotation not available (82 aa)
ENSVVUP00000019282annotation not available (310 aa)
ENSVVUP00000019285annotation not available (245 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
RBBP7Histone-binding protein RBBP7 isoform X3. (469 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1086 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MSX1Homeobox protein MSX-1. (261 aa)
CCN3Protein NOV homolog. (383 aa)
ST7LSuppressor of tumorigenicity 7 protein-like isoform X1. (589 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (692 aa)
MYL2Myosin light chain 2. (173 aa)
WT1Wilms tumor protein isoform X2. (514 aa)
FRZBSecreted frizzled-related protein 3. (333 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
DCSTAMPDendritic cell-specific transmembrane protein. (470 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
SEMA5Asemaphorin-5A isoform X1. (1072 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (199 aa)
GDF9Growth/differentiation factor 9 isoform X1. (365 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (722 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSVVUP00000033251annotation not available (226 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (525 aa)
MYL10Myosin regulatory light chain 10. (206 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (263 aa)
DCUN1D3DCN1-like protein. (304 aa)
SPHK2Sphingosine kinase 2 isoform X1. (674 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1224 aa)
CIRBPCold-inducible RNA-binding protein isoform X2. (361 aa)
STK11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (517 aa)
FBP1Fructose-1,6-bisphosphatase 1 isoform X1; Belongs to the FBPase class 1 family. (341 aa)
SEMA5Bsemaphorin-5B. (1013 aa)
EAF2ELL-associated factor 2 isoform X1. (263 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (854 aa)
MT3Metallothionein 3. (68 aa)
MYL2-2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (158 aa)
DCBLD2Discoidin, CUB and LCCL domain-containing protein 2 isoform X2. (729 aa)
FSTL4Follistatin-related protein 4 isoform X2. (823 aa)
CDKL3Cyclin-dependent kinase-like 3. (613 aa)
SFRP1Secreted frizzled-related protein 1. (293 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (769 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (750 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X2. (474 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (744 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
TP53TG5TP53-target gene 5 protein. (257 aa)
NME6Nucleoside diphosphate kinase. (198 aa)
CGRRF1Cell growth regulator with RING finger domain protein 1. (332 aa)
PLXNA3plexin-A3 isoform X1. (1846 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (448 aa)
NTN1Netrin-1. (574 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (791 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (334 aa)
SEMA3Bsemaphorin-3B isoform X1; Belongs to the semaphorin family. (748 aa)
IFRD2Interferon-related developmental regulator 2. (700 aa)
HYAL1Hyaluronidase. (435 aa)
HYAL2Hyaluronidase. (472 aa)
RB1Retinoblastoma-associated protein. (928 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (538 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SPARTSpartin. (672 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (458 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (765 aa)
GDF2Growth/differentiation factor 2. (417 aa)
DIP2BDisco-interacting protein 2 homolog B. (1574 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (355 aa)
RTN4RReticulon-4 receptor. (487 aa)
SH3BP4SH3 domain-binding protein 4. (962 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
DDX3YATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (627 aa)
OSGIN1Oxidative stress-induced growth inhibitor 1. (581 aa)
FLCNFolliculin. (935 aa)
SOX17Transcription factor SOX-18. (213 aa)
SMARCA4Transcription activator BRG1 isoform X5. (1689 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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