STRINGSTRING
CACNG6 CACNG6 CACNG4 CACNG4 CACNG1 CACNG1 ASB3 ASB3 SCN5A SCN5A CACNB3 CACNB3 ENSVVUP00000024094 ENSVVUP00000024094 KCND3 KCND3 FXYD1 FXYD1 KCND1 KCND1 ATP2B4 ATP2B4 CACNG7 CACNG7 CACNA2D1 CACNA2D1 CACNA1C CACNA1C CAPN9 CAPN9 KCND2 KCND2 CAV3 CAV3 STBD1 STBD1 CACNA1D CACNA1D PPP3CB PPP3CB DYSF DYSF ASB15 ASB15 CAPN3 CAPN3 CACNA1S CACNA1S CACNB2 CACNB2 RTN2 RTN2 CAPN3-2 CAPN3-2 CACNG5 CACNG5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (259 aa)
CACNG4Calcium voltage-gated channel auxiliary subunit gamma 4. (321 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
ASB3Ankyrin repeat and SOCS box protein 3. (558 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1860 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X2. (495 aa)
ENSVVUP00000024094annotation not available (108 aa)
KCND3Potassium voltage-gated channel subfamily D member 3 isoform X1; Belongs to the potassium channel family. (655 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (647 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5. (1024 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2088 aa)
CAPN9Calpain-9 isoform X1; Belongs to the peptidase C2 family. (696 aa)
KCND2Potassium voltage-gated channel Shal-related subfamily D member 2. (403 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
STBD1Starch binding domain 1. (322 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2167 aa)
PPP3CBSerine/threonine-protein phosphatase. (529 aa)
DYSFDysferlin isoform X8. (2153 aa)
ASB15Ankyrin repeat and SOCS box protein 15. (616 aa)
CAPN3Calpain-3 isoform X7; Belongs to the peptidase C2 family. (731 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1865 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X4. (610 aa)
RTN2Reticulon. (473 aa)
CAPN3-2Calpain-3 isoform X1. (76 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit isoform X2. (326 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.