(29 nodes) Positive regulation of telomere maintenance via telomerase network (Vulpes vulpes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	ENSVVUP00000021619	annotation not available (147 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1511 aa)
	FBXO4	F-box only protein 4. (265 aa)
	ENSVVUP00000002230	annotation not available (93 aa)
	CCT3	T-complex protein 1 subunit gamma. (596 aa)
	TCP1	T-complex protein 1 subunit alpha. (556 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (544 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (463 aa)
	ENSVVUP00000009298	annotation not available (382 aa)
	POT1	Protection of telomeres protein 1 isoform X1. (731 aa)
	ENSVVUP00000009381	annotation not available (106 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (799 aa)
	NEK2	Serine/threonine-protein kinase Nek2. (444 aa)
	CCT2	T-complex protein 1 subunit beta. (547 aa)
	CCT4	T-complex protein 1 subunit delta. (541 aa)
	ACD	Adrenocortical dysplasia protein homolog isoform X2. (400 aa)
	ENSVVUP00000017517	annotation not available (118 aa)
	MAPKAPK5	MAP kinase-activated protein kinase 5 isoform X2. (488 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3060 aa)
	ENSVVUP00000024290	annotation not available (257 aa)
	PARN	poly(A)-specific ribonuclease PARN. (638 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)
	MAPK1	Mitogen-activated protein kinase. (392 aa)
	DKC1	H/ACA ribonucleoprotein complex subunit DKC1. (580 aa)
	PNKP	Bifunctional polynucleotide phosphatase/kinase. (556 aa)
	ENSVVUP00000029631	annotation not available (489 aa)
	ENSVVUP00000033560	annotation not available (489 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	NEK7	Serine/threonine-protein kinase Nek7; Belongs to the protein kinase superfamily. (302 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	DKC1	ENSVVUP00000016952	ENSVVUP00000028325	Adrenocortical dysplasia protein homolog isoform X2.	H/ACA ribonucleoprotein complex subunit DKC1.	0.478
ACD	ENSVVUP00000029631	ENSVVUP00000016952	ENSVVUP00000029631	Adrenocortical dysplasia protein homolog isoform X2.	annotation not available	0.478
ACD	POT1	ENSVVUP00000016952	ENSVVUP00000009305	Adrenocortical dysplasia protein homolog isoform X2.	Protection of telomeres protein 1 isoform X1.	0.996
ATM	XRCC5	ENSVVUP00000020826	ENSVVUP00000012044	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.868
CCT2	CCT3	ENSVVUP00000013786	ENSVVUP00000007831	T-complex protein 1 subunit beta.	T-complex protein 1 subunit gamma.	0.995
CCT2	CCT4	ENSVVUP00000013786	ENSVVUP00000016407	T-complex protein 1 subunit beta.	T-complex protein 1 subunit delta.	0.987
CCT2	CCT7	ENSVVUP00000013786	ENSVVUP00000008872	T-complex protein 1 subunit beta.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.968
CCT2	ENSVVUP00000009381	ENSVVUP00000013786	ENSVVUP00000009381	T-complex protein 1 subunit beta.	annotation not available	0.981
CCT2	ENSVVUP00000033560	ENSVVUP00000013786	ENSVVUP00000033560	T-complex protein 1 subunit beta.	annotation not available	0.953
CCT2	TCP1	ENSVVUP00000013786	ENSVVUP00000008836	T-complex protein 1 subunit beta.	T-complex protein 1 subunit alpha.	0.990
CCT3	CCT2	ENSVVUP00000007831	ENSVVUP00000013786	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit beta.	0.995
CCT3	CCT4	ENSVVUP00000007831	ENSVVUP00000016407	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.996
CCT3	CCT7	ENSVVUP00000007831	ENSVVUP00000008872	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.996
CCT3	ENSVVUP00000009298	ENSVVUP00000007831	ENSVVUP00000009298	T-complex protein 1 subunit gamma.	annotation not available	0.992
CCT3	ENSVVUP00000009381	ENSVVUP00000007831	ENSVVUP00000009381	T-complex protein 1 subunit gamma.	annotation not available	0.995
CCT3	ENSVVUP00000021619	ENSVVUP00000007831	ENSVVUP00000021619	T-complex protein 1 subunit gamma.	annotation not available	0.993
CCT3	ENSVVUP00000033560	ENSVVUP00000007831	ENSVVUP00000033560	T-complex protein 1 subunit gamma.	annotation not available	0.994
CCT3	TCP1	ENSVVUP00000007831	ENSVVUP00000008836	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit alpha.	0.999
CCT4	CCT2	ENSVVUP00000016407	ENSVVUP00000013786	T-complex protein 1 subunit delta.	T-complex protein 1 subunit beta.	0.987
CCT4	CCT3	ENSVVUP00000016407	ENSVVUP00000007831	T-complex protein 1 subunit delta.	T-complex protein 1 subunit gamma.	0.996