22 items (Vulpes vulpes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	RYR1	LOW QUALITY PROTEIN: ryanodine receptor 1. (4780 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1000 aa)
	ATP2A3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1060 aa)
	BBS5	Kelch-like protein 41. (918 aa)
	TMEM38A	Trimeric intracellular cation channel type A. (299 aa)
	TRDN	Triadin. (136 aa)
	CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta. (633 aa)
	FKBP1B	Peptidylprolyl isomerase. (116 aa)
	DMPK	Myotonin-protein kinase isoform X1. (695 aa)
	LOC112914300	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein-like isoform X1. (675 aa)
	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6. (533 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2; Belongs to the protein kinase superfamily. (478 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (611 aa)
	STIM1	Stromal interaction molecule 1 isoform X2. (794 aa)
	ART1	NAD(P)(+)--arginine ADP-ribosyltransferase. (321 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	RYR2	Ryanodine receptor 2. (4919 aa)
	REEP5	Receptor expression-enhancing protein 5. (351 aa)
	DHRS7C	Dehydrogenase/reductase SDR family member 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
	ENSVVUP00000036743	annotation not available (110 aa)
	RYR3	Ryanodine receptor 3. (4847 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP2A1	ATP2A2	ENSVVUP00000033433	ENSVVUP00000022414	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.907
ATP2A1	BBS5	ENSVVUP00000033433	ENSVVUP00000022690	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Kelch-like protein 41.	0.488
ATP2A1	DMPK	ENSVVUP00000033433	ENSVVUP00000003970	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Myotonin-protein kinase isoform X1.	0.458
ATP2A1	PLN	ENSVVUP00000033433	ENSVVUP00000021558	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.984
ATP2A1	RYR1	ENSVVUP00000033433	ENSVVUP00000016318	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	LOW QUALITY PROTEIN: ryanodine receptor 1.	0.743
ATP2A1	RYR2	ENSVVUP00000033433	ENSVVUP00000018126	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 2.	0.513
ATP2A1	STIM1	ENSVVUP00000033433	ENSVVUP00000036055	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Stromal interaction molecule 1 isoform X2.	0.462
ATP2A1	TRDN	ENSVVUP00000033433	ENSVVUP00000000450	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Triadin.	0.528
ATP2A2	ATP2A1	ENSVVUP00000022414	ENSVVUP00000033433	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.907
ATP2A2	PLN	ENSVVUP00000022414	ENSVVUP00000021558	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.985
ATP2A2	RYR2	ENSVVUP00000022414	ENSVVUP00000018126	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 2.	0.684
ATP2A2	RYR3	ENSVVUP00000022414	ENSVVUP00000036512	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 3.	0.464
ATP2A2	TRDN	ENSVVUP00000022414	ENSVVUP00000000450	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Triadin.	0.421
ATP2A3	PLN	ENSVVUP00000036379	ENSVVUP00000021558	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.781
BBS5	ATP2A1	ENSVVUP00000022690	ENSVVUP00000033433	Kelch-like protein 41.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.488
CAMK2A	CAMK2D	ENSVVUP00000010027	ENSVVUP00000010715	Calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2; Belongs to the protein kinase superfamily.	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6.	0.900
CAMK2A	CAMK2G	ENSVVUP00000010027	ENSVVUP00000032005	Calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2; Belongs to the protein kinase superfamily.	Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1.	0.994
CAMK2A	RYR2	ENSVVUP00000010027	ENSVVUP00000018126	Calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2; Belongs to the protein kinase superfamily.	Ryanodine receptor 2.	0.918
CAMK2B	CAMK2G	ENSVVUP00000015687	ENSVVUP00000032005	Calcium/calmodulin-dependent protein kinase type II subunit beta.	Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1.	0.851
CAMK2D	CAMK2A	ENSVVUP00000010715	ENSVVUP00000010027	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6.	Calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2; Belongs to the protein kinase superfamily.	0.900