STRINGSTRING
NR5A2 NR5A2 ENSVVUP00000000714 ENSVVUP00000000714 PYGO1 PYGO1 NPAP1 NPAP1 ENSVVUP00000001731 ENSVVUP00000001731 EIF4ENIF1 EIF4ENIF1 MED1 MED1 SQSTM1 SQSTM1 LOC112912691 LOC112912691 RRP7A RRP7A PINX1 PINX1 ENSVVUP00000003416 ENSVVUP00000003416 LMNB2 LMNB2 E2F3 E2F3 KPNB1 KPNB1 BANP BANP LOC112912812 LOC112912812 NUP153 NUP153 ENSVVUP00000004499 ENSVVUP00000004499 RANGAP1 RANGAP1 LOC112912956 LOC112912956 ENSVVUP00000005011 ENSVVUP00000005011 ENSVVUP00000005533 ENSVVUP00000005533 DVL1 DVL1 NOL8 NOL8 SIX2 SIX2 IPO11 IPO11 LMNA LMNA PLK1 PLK1 FAM53B FAM53B CLDN18 CLDN18 NUP155 NUP155 PAF1 PAF1 IPO9 IPO9 SHISA4 SHISA4 KPNA2 KPNA2 GLI3 GLI3 TAF3 TAF3 RPF2 RPF2 PIK3R1 PIK3R1 NUP133 NUP133 ENSVVUP00000008924 ENSVVUP00000008924 TRAF3IP2 TRAF3IP2 SYNE1 SYNE1 IPO5 IPO5 IPO8 IPO8 TNPO1 TNPO1 ENSVVUP00000009941 ENSVVUP00000009941 TXNIP TXNIP ENSVVUP00000010211 ENSVVUP00000010211 FGF9 FGF9 RAP1GDS1 RAP1GDS1 DCLK3 DCLK3 IPO13 IPO13 BCL3 BCL3 CDK5 CDK5 TOR1AIP2 TOR1AIP2 TOR1AIP1 TOR1AIP1 PPP3CA PPP3CA KPNA7 KPNA7 UTP25 UTP25 SOX9 SOX9 OSBPL8 OSBPL8 NUP62CL NUP62CL NR5A1 NR5A1 AKIRIN2 AKIRIN2 NUP107 NUP107 NXT2 NXT2 ENSVVUP00000014502 ENSVVUP00000014502 ENSVVUP00000014600 ENSVVUP00000014600 PHB2 PHB2 TPR TPR NUP85 NUP85 LOC112931624 LOC112931624 SPG11 SPG11 ENSVVUP00000015896 ENSVVUP00000015896 XPO1 XPO1 GPN2 GPN2 NXT1 NXT1 TNPO3 TNPO3 STK3 STK3 SMO SMO ENSVVUP00000016853 ENSVVUP00000016853 NUTF2 NUTF2 ATF2 ATF2 TMCO6 TMCO6 ENSVVUP00000018044 ENSVVUP00000018044 CIZ1 CIZ1 ENSVVUP00000019188 ENSVVUP00000019188 ENSVVUP00000020138 ENSVVUP00000020138 MSX1 MSX1 KPNA6 KPNA6 NF1 NF1 FAM53A FAM53A LOC112907919 LOC112907919 GPN3 GPN3 LRRK2 LRRK2 KPNA5 KPNA5 PRICKLE1 PRICKLE1 NUP35 NUP35 GCKR GCKR ABRA ABRA BMP7 BMP7 HIKESHI HIKESHI FAM53C FAM53C CNEP1R1 CNEP1R1 HEATR3 HEATR3 BBS4 BBS4 RRS1 RRS1 PML PML ENSVVUP00000025385 ENSVVUP00000025385 STK4 STK4 ENSVVUP00000025994 ENSVVUP00000025994 PPP3R2 PPP3R2 SNUPN SNUPN XPA XPA WRN WRN ING1 ING1 NFKBIA NFKBIA MORC3 MORC3 RANBP2 RANBP2 TBRG1 TBRG1 APPL1 APPL1 TOPORS TOPORS ENSVVUP00000028967 ENSVVUP00000028967 ENSVVUP00000028969 ENSVVUP00000028969 ENSVVUP00000029061 ENSVVUP00000029061 YWHAE YWHAE NUP93 NUP93 HHEX HHEX SYK SYK CSE1L CSE1L KPNA1 KPNA1 ABCA7 ABCA7 STK11 STK11 KPNA4 KPNA4 APPL2 APPL2 NOP53 NOP53 SEC13 SEC13 NUP54 NUP54 ARL2BP ARL2BP STAT3 STAT3 PTTG1IP PTTG1IP TNPO2 TNPO2 ENSVVUP00000033247 ENSVVUP00000033247 ENSVVUP00000033849 ENSVVUP00000033849 LOC112935781 LOC112935781 PLRG1 PLRG1 ADGRD1 ADGRD1 RAN RAN ENSVVUP00000036059 ENSVVUP00000036059 PARK7 PARK7 CDKN1A CDKN1A HNRNPU HNRNPU DCLK1 DCLK1 ENSVVUP00000037228 ENSVVUP00000037228 NOTCH1 NOTCH1 TAF8 TAF8 NUP188 NUP188 RPL11 RPL11 ENSVVUP00000037686 ENSVVUP00000037686 ELAVL1 ELAVL1 CRY2 CRY2 POLA2 POLA2 TOR1B TOR1B TOR1A TOR1A RPAIN RPAIN NUP88 NUP88 ARL2 ARL2 IPO7 IPO7 PPP3R1 PPP3R1 CTDNEP1 CTDNEP1 TP53 TP53 WRAP53 WRAP53 NUP214 NUP214 KPNA3 KPNA3 RANGRF RANGRF NUP50 NUP50 TXN TXN SUN1 SUN1 ENSVVUP00000040742 ENSVVUP00000040742 ENSVVUP00000040743 ENSVVUP00000040743 IPO4 IPO4 SIX4 SIX4 SIX1 SIX1 BMP4 BMP4 ENSVVUP00000042464 ENSVVUP00000042464 LMNB1 LMNB1 INTS13 INTS13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR5A2Nuclear receptor subfamily 5 group A member 2 isoform X1. (519 aa)
ENSVVUP00000000714annotation not available (127 aa)
PYGO1Pygopus homolog 1. (394 aa)
NPAP1Nuclear pore-associated protein 1. (836 aa)
ENSVVUP00000001731annotation not available (403 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E transporter isoform X2. (1002 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
SQSTM1Sequestosome-1. (444 aa)
LOC112912691STAGA complex 65 subunit gamma-like. (143 aa)
RRP7ARibosomal RNA-processing protein 7 homolog A. (444 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (512 aa)
ENSVVUP00000003416annotation not available (298 aa)
LMNB2lamin-B2; Belongs to the intermediate filament family. (667 aa)
E2F3Transcription factor E2F3. (224 aa)
KPNB1Importin subunit beta-1. (876 aa)
BANPProtein BANP isoform X2. (530 aa)
LOC112912812ELAV-like protein 1. (296 aa)
NUP153Nuclear pore complex protein Nup153. (1478 aa)
ENSVVUP00000004499annotation not available (1082 aa)
RANGAP1Ran GTPase-activating protein 1 isoform X1. (587 aa)
LOC112912956torsin-1B-like. (173 aa)
ENSVVUP00000005011annotation not available (177 aa)
ENSVVUP00000005533annotation not available (190 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
NOL8Nucleolar protein 8. (1142 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
IPO11Importin-11 isoform X1. (943 aa)
LMNALamin; Belongs to the intermediate filament family. (685 aa)
PLK1Serine/threonine-protein kinase PLK. (607 aa)
FAM53BProtein FAM53B. (426 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
NUP155Nuclear pore complex protein Nup155 isoform X1. (1391 aa)
PAF1RNA polymerase II-associated factor 1 homolog. (721 aa)
IPO9Importin-9. (1003 aa)
SHISA4Protein shisa-4. (181 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (548 aa)
GLI3LOW QUALITY PROTEIN: transcriptional activator GLI3. (1522 aa)
TAF3Transcription initiation factor TFIID subunit 3. (943 aa)
RPF2Ribosome production factor 2 homolog. (283 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
NUP133Nuclear pore complex protein Nup133. (1182 aa)
ENSVVUP00000008924annotation not available (159 aa)
TRAF3IP2Adapter protein CIKS isoform X2. (551 aa)
SYNE1Nesprin-1. (2833 aa)
IPO5Importin-5. (1097 aa)
IPO8Importin-8 isoform X2. (1037 aa)
TNPO1Transportin-1. (1075 aa)
ENSVVUP00000009941annotation not available (1578 aa)
TXNIPThioredoxin-interacting protein. (391 aa)
ENSVVUP00000010211annotation not available (160 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1 isoform X1. (644 aa)
DCLK3Serine/threonine-protein kinase DCLK3. (467 aa)
IPO13Importin-13 isoform X1. (963 aa)
BCL3BCL3 transcription coactivator. (331 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X3; Belongs to the protein kinase superfamily. (383 aa)
TOR1AIP2torsin-1A-interacting protein 2-like. (468 aa)
TOR1AIP1torsin-1A-interacting protein 1 isoform X1. (792 aa)
PPP3CASerine/threonine-protein phosphatase. (572 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (496 aa)
UTP25Digestive organ expansion factor homolog. (758 aa)
SOX9LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (938 aa)
NUP62CLNucleoporin-62 C-terminal-like protein isoform X1. (179 aa)
NR5A1Steroidogenic factor 1. (461 aa)
AKIRIN2Akirin-2. (213 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (927 aa)
NXT2NTF2-related export protein 2 isoform X1. (199 aa)
ENSVVUP00000014502annotation not available (106 aa)
ENSVVUP00000014600annotation not available (76 aa)
PHB2Prohibitin. (297 aa)
TPRNucleoprotein TPR. (2511 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (659 aa)
LOC112931624Importin subunit alpha-8-like. (296 aa)
SPG11Spatacsin. (2451 aa)
ENSVVUP00000015896annotation not available (101 aa)
XPO1Exportin-1 isoform X1. (1071 aa)
GPN2GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (310 aa)
NXT1NTF2-related export protein 1. (140 aa)
TNPO3Transportin-3 isoform X1. (978 aa)
STK3Serine/threonine-protein kinase 3. (508 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (802 aa)
ENSVVUP00000016853annotation not available (107 aa)
NUTF2Nuclear transport factor 2. (127 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
TMCO6Transmembrane and coiled-coil domain-containing protein 6 isoform X2. (492 aa)
ENSVVUP00000018044annotation not available (985 aa)
CIZ1Cip1-interacting zinc finger protein isoform X1. (858 aa)
ENSVVUP00000019188annotation not available (143 aa)
ENSVVUP00000020138annotation not available (464 aa)
MSX1Homeobox protein MSX-1. (261 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (541 aa)
NF1Neurofibromin. (2816 aa)
FAM53AProtein FAM53A isoform X1. (392 aa)
LOC112907919Nuclear envelope pore membrane protein POM 121-like. (759 aa)
GPN3GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (284 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (543 aa)
PRICKLE1Prickle-like protein 1. (832 aa)
NUP35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (356 aa)
GCKRGlucokinase regulatory protein isoform X2. (600 aa)
ABRAActin-binding Rho-activating protein. (380 aa)
BMP7Bone morphogenetic protein 7. (432 aa)
HIKESHIProtein Hikeshi. (197 aa)
FAM53CProtein FAM53C. (392 aa)
CNEP1R1Nuclear envelope phosphatase-regulatory subunit 1. (143 aa)
HEATR3HEAT repeat-containing protein 3 isoform X1. (910 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X1. (520 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
PMLProtein PML. (406 aa)
ENSVVUP00000025385annotation not available (161 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (494 aa)
ENSVVUP00000025994annotation not available (127 aa)
PPP3R2Calcineurin subunit B type 2. (252 aa)
SNUPNSnurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family. (358 aa)
XPADNA repair protein complementing XP-A cells isoform X1. (272 aa)
WRNWerner syndrome ATP-dependent helicase. (1455 aa)
ING1Inhibitor of growth protein. (279 aa)
NFKBIANF-kappa-B inhibitor alpha. (327 aa)
MORC3MORC family CW-type zinc finger protein 3 isoform X1. (939 aa)
RANBP2E3 SUMO-protein ligase RanBP2 isoform X4. (3265 aa)
TBRG1Transforming growth factor beta regulator 1 isoform X2. (426 aa)
APPL1DCC-interacting protein 13-alpha. (672 aa)
TOPORSE3 ubiquitin-protein ligase Topors. (1043 aa)
ENSVVUP00000028967annotation not available (416 aa)
ENSVVUP00000028969annotation not available (85 aa)
ENSVVUP00000029061annotation not available (252 aa)
YWHAE14-3-3 protein epsilon isoform X3; Belongs to the 14-3-3 family. (244 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
HHEXHematopoietically expressed homeobox. (228 aa)
SYKTyrosine-protein kinase. (610 aa)
CSE1LExportin-2 isoform X1. (979 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
ABCA7ATP-binding cassette sub-family A member 7. (2042 aa)
STK11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (517 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (521 aa)
APPL2DCC-interacting protein 13-beta isoform X2. (695 aa)
NOP53Ribosome biogenesis protein NOP53 isoform X1. (498 aa)
SEC13Protein SEC13 homolog; Belongs to the WD repeat SEC13 family. (308 aa)
NUP54Nucleoporin p54 isoform X2. (508 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein. (163 aa)
STAT3Signal transducer and activator of transcription. (791 aa)
PTTG1IPPituitary tumor-transforming gene 1 protein-interacting protein. (115 aa)
TNPO2Transportin-2. (848 aa)
ENSVVUP00000033247annotation not available (386 aa)
ENSVVUP00000033849annotation not available (314 aa)
LOC112935781Nuclear envelope pore membrane protein POM 121C-like. (1057 aa)
PLRG1Pleiotropic regulator 1 isoform X1. (515 aa)
ADGRD1Adhesion G-protein coupled receptor D1 isoform X2; Belongs to the G-protein coupled receptor 2 family. (905 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
ENSVVUP00000036059annotation not available (384 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X2. (806 aa)
DCLK1Serine/threonine-protein kinase DCLK1 isoform X6; Belongs to the protein kinase superfamily. (423 aa)
ENSVVUP00000037228annotation not available (126 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2644 aa)
TAF8Transcription initiation factor TFIID subunit 8 isoform X1. (310 aa)
NUP188Nucleoporin NUP188 homolog isoform X1. (1764 aa)
RPL1160S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (196 aa)
ENSVVUP00000037686annotation not available (410 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (350 aa)
CRY2Cryptochrome-2. (600 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (586 aa)
TOR1BTorsin. (379 aa)
TOR1ATorsin. (332 aa)
RPAINRPA-interacting protein. (280 aa)
NUP88Nuclear pore complex protein Nup88. (867 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform X3; Belongs to the small GTPase superfamily. Arf family. (184 aa)
IPO7Importin-7 isoform X1. (1042 aa)
PPP3R1Calcineurin subunit B type 1. (192 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (226 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
WRAP53Telomerase Cajal body protein 1 isoform X2. (539 aa)
NUP214LOW QUALITY PROTEIN: nuclear pore complex protein Nup214. (2088 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (497 aa)
RANGRFRan guanine nucleotide release factor isoform X1. (186 aa)
NUP50Nuclear pore complex protein Nup50. (467 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
SUN1SUN domain-containing protein 1 isoform X2. (981 aa)
ENSVVUP00000040742annotation not available (77 aa)
ENSVVUP00000040743annotation not available (421 aa)
IPO4Importin-4. (1121 aa)
SIX4Homeobox protein SIX4. (801 aa)
SIX1Homeobox protein SIX1. (284 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (409 aa)
ENSVVUP00000042464annotation not available (399 aa)
LMNB1lamin-B1 isoform X1; Belongs to the intermediate filament family. (586 aa)
INTS13Integrator complex subunit 13 isoform X1. (706 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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