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RACK1 RACK1 ASPSCR1 ASPSCR1 STXBP3 STXBP3 NR1D1 NR1D1 ENSVVUP00000001460 ENSVVUP00000001460 HK3 HK3 IL6 IL6 LOC112921570 LOC112921570 CSRP3 CSRP3 PRKAA1 PRKAA1 PTPRN2 PTPRN2 LOC112912760 LOC112912760 INS INS APPL2 APPL2 SOX4 SOX4 FOXA3 FOXA3 NGFR NGFR HK2 HK2 PDK2 PDK2 TRPV4 TRPV4 PIK3CA PIK3CA FOXO3 FOXO3 SLC39A14 SLC39A14 FOXK2 FOXK2 FOXK1 FOXK1 ERN1 ERN1 LOC112923739 LOC112923739 PIK3R1 PIK3R1 ADIPOR1 ADIPOR1 CARTPT CARTPT WFS1 WFS1 RMI1 RMI1 ADRA2C ADRA2C ENSVVUP00000011174 ENSVVUP00000011174 TCF7L2 TCF7L2 ENSVVUP00000011482 ENSVVUP00000011482 GCK GCK ENSVVUP00000011849 ENSVVUP00000011849 PDX1 PDX1 PIK3R2 PIK3R2 PTCH1 PTCH1 STK11 STK11 MCU MCU KCNB1 KCNB1 STXBP5L STXBP5L ZBTB20 ZBTB20 INPP5K INPP5K RPH3AL RPH3AL HK1 HK1 HKDC1 HKDC1 HNF1A HNF1A ALOX5 ALOX5 FOXA1 FOXA1 ADIPOR2 ADIPOR2 GCGR GCGR SIRT1 SIRT1 CYB5R4 CYB5R4 SIN3A SIN3A CCN4 CCN4 HNF4A HNF4A NOX4 NOX4 GCG GCG NR1H4 NR1H4 CYP7A1 CYP7A1 PRCP PRCP PCK1 PCK1 GCKR GCKR ADCY8 ADCY8 ENSVVUP00000023156 ENSVVUP00000023156 GPR1 GPR1 G6PC2 G6PC2 RFX6 RFX6 PAX6 PAX6 NCOA5 NCOA5 FAM3B FAM3B BACE2 BACE2 GPI GPI FBN1 FBN1 PDK4 PDK4 LEPR LEPR CRY2 CRY2 SLC2A4 SLC2A4 PLSCR3 PLSCR3 INSR INSR GPER1 GPER1 PCK2 PCK2 ADGRF5 ADGRF5 TFAP2B TFAP2B HIF1A HIF1A CSMD1 CSMD1 PYGL PYGL BAD BAD LRRC8D LRRC8D RAF1 RAF1 BHLHA15 BHLHA15 IGF1R IGF1R ENSVVUP00000019211 ENSVVUP00000019211 NUCKS1 NUCKS1 KAT5 KAT5 PTPN2 PTPN2 GAS6 GAS6 ADIPOQ ADIPOQ TRA2B TRA2B SELENOT-2 SELENOT-2 HECTD4 HECTD4 LOC112912623 LOC112912623 KLF7 KLF7 ENSVVUP00000015945 ENSVVUP00000015945 SESN3 SESN3 SELENOT SELENOT MBD5 MBD5 SUCNR1 SUCNR1 RAB11FIP2 RAB11FIP2 PTPN11 PTPN11 SLC8B1 SLC8B1 CNR1 CNR1 CCDC186 CCDC186 ENSVVUP00000012830 ENSVVUP00000012830 ENSVVUP00000037390 ENSVVUP00000037390 PRKAA2 PRKAA2 PARK7 PARK7 LRRC8A LRRC8A CAV3 CAV3 SLC12A6 SLC12A6 SIDT2 SIDT2 AGER AGER MLXIPL MLXIPL SLC37A4 SLC37A4 DHPS DHPS STAT3 STAT3 VGF VGF CRY1 CRY1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RACK1Receptor of activated protein C kinase 1. (317 aa)
ASPSCR1Tether containing UBX domain for GLUT4. (568 aa)
STXBP3Syntaxin-binding protein 3 isoform X4; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (617 aa)
ENSVVUP00000001460annotation not available (223 aa)
HK3Hexokinase-3. (965 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (207 aa)
LOC112921570Ankyrin repeat domain-containing protein 26-like isoform X1. (1689 aa)
CSRP3Cysteine and glycine-rich protein 3. (194 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PTPRN2Receptor-type tyrosine-protein phosphatase N2. (1041 aa)
LOC112912760Ankyrin repeat domain-containing protein 26-like. (201 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
APPL2DCC-interacting protein 13-beta isoform X2. (695 aa)
SOX4Transcription factor SOX-4. (170 aa)
FOXA3Hepatocyte nuclear factor 3-gamma. (369 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (423 aa)
HK2Hexokinase-2. (917 aa)
PDK2Protein-serine/threonine kinase. (408 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXO3Forkhead box protein O3. (453 aa)
SLC39A14Zinc transporter ZIP14 isoform X1. (521 aa)
FOXK2LOW QUALITY PROTEIN: forkhead box protein K2. (622 aa)
FOXK1Forkhead box protein K1. (611 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (991 aa)
LOC112923739LOW QUALITY PROTEIN: fatty acid-binding protein 5. (104 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (132 aa)
WFS1Wolframin isoform X2. (999 aa)
RMI1recQ-mediated genome instability protein 1. (649 aa)
ADRA2Calpha-2C adrenergic receptor. (297 aa)
ENSVVUP00000011174annotation not available (238 aa)
TCF7L2Transcription factor 7-like 2 isoform X2. (507 aa)
ENSVVUP00000011482annotation not available (162 aa)
GCKPhosphotransferase. (481 aa)
ENSVVUP00000011849annotation not available (98 aa)
PDX1Pancreas/duodenum homeobox protein 1. (282 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (735 aa)
PTCH1Protein patched homolog 1 isoform X3. (1386 aa)
STK11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (517 aa)
MCUCalcium uniporter protein, mitochondrial isoform X1. (337 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
STXBP5LSyntaxin-binding protein 5-like isoform X1. (1237 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (741 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (451 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (325 aa)
HK1Hexokinase-1. (935 aa)
HKDC1Putative hexokinase HKDC1. (923 aa)
HNF1AHepatocyte nuclear factor 1-alpha isoform X1. (661 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
FOXA1LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha. (440 aa)
ADIPOR2Adiponectin receptor protein 2. (385 aa)
GCGRLOW QUALITY PROTEIN: glucagon receptor; Belongs to the G-protein coupled receptor 2 family. (492 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (769 aa)
CYB5R4Cytochrome b5 reductase 4 isoform X1. (519 aa)
SIN3APaired amphipathic helix protein Sin3a. (1274 aa)
CCN4WNT1-inducible-signaling pathway protein 1. (362 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X2. (474 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
GCGGlucagon. (171 aa)
NR1H4Bile acid receptor isoform X2. (481 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
PRCPLysosomal Pro-X carboxypeptidase isoform X1. (632 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
GCKRGlucokinase regulatory protein isoform X2. (600 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
ENSVVUP00000023156annotation not available (593 aa)
GPR1G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
RFX6DNA-binding protein RFX6. (919 aa)
PAX6Paired box protein Pax-6 isoform X2. (422 aa)
NCOA5Nuclear receptor coactivator 5 isoform X1. (579 aa)
FAM3BProtein FAM3B isoform X1. (350 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (471 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (941 aa)
FBN1Fibrillin-1. (2881 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
LEPRLeptin receptor isoform X1. (1172 aa)
CRY2Cryptochrome-2. (600 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (510 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (297 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
ADGRF5Adhesion G protein-coupled receptor F5 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1404 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (460 aa)
HIF1AHypoxia-inducible factor 1-alpha. (764 aa)
CSMD1CUB and sushi domain-containing protein 1. (3368 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
BADBcl2-associated agonist of cell death. (157 aa)
LRRC8DVolume-regulated anion channel subunit LRRC8D. (877 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
BHLHA15Class A basic helix-loop-helix protein 15. (187 aa)
IGF1RTyrosine-protein kinase receptor. (1249 aa)
ENSVVUP00000019211annotation not available (82 aa)
NUCKS1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1. (243 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
GAS6Growth arrest-specific protein 6. (655 aa)
ADIPOQAdiponectin. (266 aa)
TRA2BTransformer-2 protein homolog beta isoform X1. (478 aa)
SELENOT-2Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
HECTD4Probable E3 ubiquitin-protein ligase HECTD4 isoform X7. (4475 aa)
LOC112912623Coiled-coil domain-containing protein 144B-like. (1459 aa)
KLF7Krueppel-like factor 7 isoform X2. (334 aa)
ENSVVUP00000015945annotation not available (147 aa)
SESN3Sestrin-3 isoform X2. (469 aa)
SELENOTSelenoprotein T. (133 aa)
MBD5methyl-CpG-binding domain protein 5 isoform X4. (1500 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (342 aa)
RAB11FIP2Rab11 family-interacting protein 2. (512 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
SLC8B1Mitochondrial sodium/calcium exchanger protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (597 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
CCDC186Coiled-coil domain-containing protein 186. (896 aa)
ENSVVUP00000012830annotation not available (123 aa)
ENSVVUP00000037390annotation not available (101 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
LRRC8AVolume-regulated anion channel subunit LRRC8A. (810 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SLC12A6Solute carrier family 12 member 6 isoform X1. (1151 aa)
SIDT2SID1 transmembrane family member 2 isoform X3. (1018 aa)
AGERAdvanced glycosylation end product-specific receptor. (405 aa)
MLXIPLCarbohydrate-responsive element-binding protein isoform X1. (907 aa)
SLC37A4Glucose-6-phosphate exchanger SLC37A4 isoform X1. (451 aa)
DHPSDeoxyhypusine synthase isoform X1. (369 aa)
STAT3Signal transducer and activator of transcription. (791 aa)
VGFLOW QUALITY PROTEIN: neurosecretory protein VGF. (359 aa)
CRY1Cryptochrome-1. (596 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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