(38 nodes) Negative regulation of MAP kinase activity network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (427 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (409 aa)
	DEFB114	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (933 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	PAQR3	Progestin and adipoQ receptor family member 3. (311 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	PTPRJ	Receptor-type tyrosine-protein phosphatase eta. (1224 aa)
	INPP5K	Inositol polyphosphate 5-phosphatase K isoform X1. (451 aa)
	SPRY4	Protein sprouty homolog 4. (344 aa)
	SORL1	Sortilin-related receptor. (2136 aa)
	SFRP1	Secreted frizzled-related protein 1. (293 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	BMP7	Bone morphogenetic protein 7. (432 aa)
	SH2B3	SH2B adapter protein 3. (355 aa)
	NF1	Neurofibromin. (2816 aa)
	TMEM130	Transmembrane protein 130 isoform X1. (435 aa)
	LAX1	Lymphocyte transmembrane adapter 1. (393 aa)
	SPRY2	Protein sprouty homolog 2. (315 aa)
	SPRY1	Protein sprouty homolog 1 isoform X1. (342 aa)
	ADIPOQ	Adiponectin. (266 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3. (597 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (636 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	DUSP10	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	LOC112920766	CMRF35-like molecule 8 isoform X1. (312 aa)
	NUP62CL	Nucleoporin-62 C-terminal-like protein isoform X1. (179 aa)
	DAB2IP	Disabled homolog 2-interacting protein isoform X1. (1090 aa)
	CBLC	E3 ubiquitin-protein ligase CBL-C. (450 aa)
	APOE	Apolipoprotein E. (336 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (477 aa)
	DUSP16	Dual specificity protein phosphatase 16. (663 aa)
	GBA	Glucosylceramidase. (564 aa)
	CDK5RAP3	CDK5 regulatory subunit-associated protein 3. (504 aa)
	SPRY3	Protein sprouty homolog 3. (288 aa)
	RGS14	Regulator of G-protein signaling 14 isoform X1. (584 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APOE	ENSVVUP00000018002	ENSVVUP00000011276	Adiponectin.	Apolipoprotein E.	0.456
ADIPOQ	CAV1	ENSVVUP00000018002	ENSVVUP00000014366	Adiponectin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.436
ADIPOQ	PAQR3	ENSVVUP00000018002	ENSVVUP00000034302	Adiponectin.	Progestin and adipoQ receptor family member 3.	0.544
AGT	APOE	ENSVVUP00000009089	ENSVVUP00000011276	Angiotensinogen; Belongs to the serpin family.	Apolipoprotein E.	0.465
APOE	ADIPOQ	ENSVVUP00000011276	ENSVVUP00000018002	Apolipoprotein E.	Adiponectin.	0.456
APOE	AGT	ENSVVUP00000011276	ENSVVUP00000009089	Apolipoprotein E.	Angiotensinogen; Belongs to the serpin family.	0.465
APOE	CAV1	ENSVVUP00000011276	ENSVVUP00000014366	Apolipoprotein E.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.606
APOE	HMGCR	ENSVVUP00000011276	ENSVVUP00000034999	Apolipoprotein E.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.524
APOE	SORL1	ENSVVUP00000011276	ENSVVUP00000028293	Apolipoprotein E.	Sortilin-related receptor.	0.661
BMP2	BMP4	ENSVVUP00000032146	ENSVVUP00000041694	Bone morphogenetic protein 2.	Bone morphogenetic protein 4 isoform X2.	0.929
BMP2	BMP7	ENSVVUP00000032146	ENSVVUP00000023613	Bone morphogenetic protein 2.	Bone morphogenetic protein 7.	0.671
BMP4	BMP2	ENSVVUP00000041694	ENSVVUP00000032146	Bone morphogenetic protein 4 isoform X2.	Bone morphogenetic protein 2.	0.929
BMP4	BMP7	ENSVVUP00000041694	ENSVVUP00000023613	Bone morphogenetic protein 4 isoform X2.	Bone morphogenetic protein 7.	0.801
BMP4	SPRY2	ENSVVUP00000041694	ENSVVUP00000019273	Bone morphogenetic protein 4 isoform X2.	Protein sprouty homolog 2.	0.440
BMP7	BMP2	ENSVVUP00000023613	ENSVVUP00000032146	Bone morphogenetic protein 7.	Bone morphogenetic protein 2.	0.671
BMP7	BMP4	ENSVVUP00000023613	ENSVVUP00000041694	Bone morphogenetic protein 7.	Bone morphogenetic protein 4 isoform X2.	0.801
CAV1	ADIPOQ	ENSVVUP00000014366	ENSVVUP00000018002	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adiponectin.	0.436
CAV1	APOE	ENSVVUP00000014366	ENSVVUP00000011276	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Apolipoprotein E.	0.606
CAV1	CAV3	ENSVVUP00000014366	ENSVVUP00000035215	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.958
CAV3	CAV1	ENSVVUP00000035215	ENSVVUP00000014366	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.958