STRINGSTRING
LTB LTB ADAM9 ADAM9 ST14 ST14 PLA2G10 PLA2G10 BCR BCR JUP JUP KRT17 KRT17 KRT16 KRT16 STK4 STK4 SOS1 SOS1 NSUN2 NSUN2 ENSVVUP00000023631 ENSVVUP00000023631 WNT16 WNT16 FOXN1 FOXN1 FGF7 FGF7 EZH2 EZH2 SLC2A10 SLC2A10 PAX6 PAX6 TBC1D31 TBC1D31 IL18 IL18 LOC112907995 LOC112907995 ENSVVUP00000021418 ENSVVUP00000021418 FLG2 FLG2 ENSVVUP00000021365 ENSVVUP00000021365 ENSVVUP00000021351 ENSVVUP00000021351 EXT1 EXT1 COL1A2 COL1A2 EXPH5 EXPH5 ITGA6 ITGA6 LDB2 LDB2 NF1 NF1 LSR LSR PUM2 PUM2 ITGB4 ITGB4 SMAD4 SMAD4 CERS3 CERS3 CD109 CD109 CLDN1 CLDN1 SLC27A4 SLC27A4 TP63 TP63 CDH3 CDH3 CASP3 CASP3 TGFB2 TGFB2 SMO SMO KDF1 KDF1 SFN SFN APCDD1 APCDD1 INTU INTU CDSN CDSN YAP1 YAP1 LHX2 LHX2 SOX9 SOX9 PKD1 PKD1 IRF6 IRF6 CNFN CNFN PPP3CA PPP3CA ABCA12 ABCA12 SOSTDC1 SOSTDC1 LGR5 LGR5 ELOVL1 ELOVL1 PIAS4 PIAS4 COMP COMP TNFRSF19 TNFRSF19 PTCH2 PTCH2 LATS2 LATS2 TXNIP TXNIP LOC112907671 LOC112907671 EDA EDA CYP26B1 CYP26B1 DLL1 DLL1 TRAF3IP2 TRAF3IP2 SLITRK5 SLITRK5 INHBA INHBA NSDHL NSDHL TMEM79 TMEM79 WDR48 WDR48 ZMPSTE24 ZMPSTE24 LATS1 LATS1 DSP DSP PALLD PALLD COL1A1 COL1A1 SUFU SUFU ITGA3 ITGA3 TRPC4AP TRPC4AP DLX3 DLX3 ERCC2 ERCC2 ASH1L ASH1L GATA6 GATA6 NGFR NGFR ENSVVUP00000004499 ENSVVUP00000004499 FZD3 FZD3 ANXA1 ANXA1 TSG101 TSG101 LDB1 LDB1 NOM1 NOM1 FOSL2 FOSL2 UGCG UGCG MED1 MED1 ADAMTS2 ADAMTS2 WNT10A WNT10A LGR4 LGR4 EDAR EDAR IFT74 IFT74 CASP14 CASP14 PLEC PLEC ARRDC3 ARRDC3 SNAI1 SNAI1 MADCAM1 MADCAM1 CSTA CSTA ZDHHC21 ZDHHC21 POU3F2 POU3F2 FA2H FA2H KRT10 KRT10 KRT27 KRT27 KRT26 KRT26 KRT25 KRT25 FRAS1 FRAS1 CELSR1 CELSR1 GORAB GORAB FGF10 FGF10 FST FST TGM3 TGM3 ABCB6 ABCB6 PNPLA1 PNPLA1 ERRFI1 ERRFI1 ENSVVUP00000036810 ENSVVUP00000036810 OPN3 OPN3 NOTCH1 NOTCH1 LRP4 LRP4 DHCR24 DHCR24 ACER1 ACER1 GRHL3 GRHL3 OVOL1 OVOL1 RELA RELA CLIC4 CLIC4 ALX4 ALX4 STARD7 STARD7 DSG4 DSG4 KEL KEL ALOX12 ALOX12 ACVR1B ACVR1B KRT80 KRT80 KRT7 KRT7 LOC112921255 LOC112921255 LOC112920992 LOC112920992 LOC112920993 LOC112920993 LOC112920994 LOC112920994 LOC112921256 LOC112921256 KRT85 KRT85 KRT84 KRT84 COL5A2 COL5A2 KRT82 KRT82 LOC112920998 LOC112920998 KRT75 KRT75 LOC112920999 LOC112920999 KRT6A KRT6A KRT5 KRT5 KRT71 KRT71 KRT74 KRT74 KRT72 KRT72 KRT73 KRT73 KRT77 KRT77 LOC112921008 LOC112921008 KRT76 KRT76 KRT3 KRT3 KRT4 KRT4 KRT79 KRT79 KRT78 KRT78 KRT8 KRT8 ALOX12B ALOX12B HOXC13 HOXC13 BCL11B BCL11B SRF SRF ENSVVUP00000040567 ENSVVUP00000040567 KAZN KAZN EPHA2 EPHA2 TGM1 TGM1 SAV1 SAV1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LTBLymphotoxin-beta; Belongs to the tumor necrosis factor family. (247 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9. (819 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (832 aa)
PLA2G10Phospholipase A(2). (152 aa)
BCRBreakpoint cluster region protein. (1367 aa)
JUPJunction plakoglobin. (842 aa)
KRT17Keratin, type I cytoskeletal 17; Belongs to the intermediate filament family. (433 aa)
KRT16Keratin, type I cytoskeletal 16; Belongs to the intermediate filament family. (472 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (494 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
NSUN2tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (712 aa)
ENSVVUP00000023631annotation not available (142 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
FOXN1Forkhead box protein N1. (645 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X7. (751 aa)
SLC2A10Solute carrier family 2, facilitated glucose transporter member 10 isoform X4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
PAX6Paired box protein Pax-6 isoform X2. (422 aa)
TBC1D31TBC1 domain family member 31 isoform X1. (1215 aa)
IL18Interleukin-18. (236 aa)
LOC112907995cornifin-A. (88 aa)
ENSVVUP00000021418annotation not available (113 aa)
FLG2Filaggrin-2. (267 aa)
ENSVVUP00000021365annotation not available (895 aa)
ENSVVUP00000021351annotation not available (591 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (537 aa)
COL1A2Collagen alpha-2(I) chain. (1274 aa)
EXPH5Exophilin-5 isoform X1. (2087 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1082 aa)
LDB2LIM domain-binding protein 2 isoform X1. (373 aa)
NF1Neurofibromin. (2816 aa)
LSRLipolysis-stimulated lipoprotein receptor. (621 aa)
PUM2Pumilio homolog 2 isoform X2. (1063 aa)
ITGB4Integrin beta. (1805 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CERS3Ceramide synthase 3. (396 aa)
CD109CD109 antigen. (1445 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (676 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (988 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (355 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (802 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
APCDD1Protein APCDD1 isoform X1. (498 aa)
INTUProtein inturned isoform X2. (940 aa)
CDSNCorneodesmosin. (510 aa)
YAP1Transcriptional coactivator YAP1. (431 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
SOX9LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
PKD1Polycystin-1. (3467 aa)
IRF6Interferon regulatory factor 6. (462 aa)
CNFNCornifelin. (124 aa)
PPP3CASerine/threonine-protein phosphatase. (572 aa)
ABCA12ATP-binding cassette sub-family A member 12. (2609 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (296 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (279 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (597 aa)
COMPCartilage oligomeric matrix protein. (332 aa)
TNFRSF19Tumor necrosis factor receptor superfamily member 19. (415 aa)
PTCH2Protein patched homolog 2 isoform X2. (1207 aa)
LATS2Non-specific serine/threonine protein kinase. (1085 aa)
TXNIPThioredoxin-interacting protein. (391 aa)
LOC112907671Golgi pH regulator isoform X1. (545 aa)
EDAectodysplasin-A; Belongs to the tumor necrosis factor family. (259 aa)
CYP26B1Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (561 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
TRAF3IP2Adapter protein CIKS isoform X2. (551 aa)
SLITRK5SLIT and NTRK-like protein 5. (1137 aa)
INHBAInhibin beta A chain. (424 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating isoform X2; Belongs to the 3-beta-HSD family. (361 aa)
TMEM79Transmembrane protein 79. (395 aa)
WDR48WD repeat-containing protein 48 isoform X1. (677 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
LATS1Serine/threonine-protein kinase LATS1 isoform X1. (1127 aa)
DSPDesmoplakin isoform X2. (2215 aa)
PALLDPalladin. (1329 aa)
COL1A1Collagen alpha-1(I) chain. (1288 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (970 aa)
TRPC4APShort transient receptor potential channel 4-associated protein isoform X1. (797 aa)
DLX3Homeobox protein DLX-3. (287 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform X1. (760 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X2. (2965 aa)
GATA6Transcription factor GATA-6. (571 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (423 aa)
ENSVVUP00000004499annotation not available (1082 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ANXA1Annexin. (345 aa)
TSG101LOW QUALITY PROTEIN: tumor susceptibility gene 101 protein. (373 aa)
LDB1LIM domain-binding protein 1 isoform X3. (411 aa)
NOM1Nucleolar MIF4G domain-containing protein 1 isoform X2. (863 aa)
FOSL2Fos-related antigen 2. (325 aa)
UGCGCeramide glucosyltransferase. (394 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
ADAMTS2A disintegrin and metalloproteinase with thrombospondin motifs 2. (1189 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (955 aa)
EDARTumor necrosis factor receptor superfamily member EDAR. (479 aa)
IFT74Intraflagellar transport protein 74 homolog. (600 aa)
CASP14Caspase-14; Belongs to the peptidase C14A family. (242 aa)
PLECPlectin. (4948 aa)
ARRDC3Arrestin domain-containing protein 3 isoform X1. (414 aa)
SNAI1Zinc finger protein SNAI1 isoform X1. (264 aa)
MADCAM1Mucosal addressin cell adhesion molecule 1. (398 aa)
CSTAcystatin-A; Belongs to the cystatin family. (93 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
POU3F2POU domain protein. (217 aa)
FA2HFatty acid 2-hydroxylase; Belongs to the cytochrome b5 family. (369 aa)
KRT10LOW QUALITY PROTEIN: keratin, type I cytoskeletal 10; Belongs to the intermediate filament family. (579 aa)
KRT27Keratin, type I cytoskeletal 27 isoform X1. (446 aa)
KRT26Keratin, type I cytoskeletal 26-like; Belongs to the intermediate filament family. (464 aa)
KRT25Keratin, type I cytoskeletal 25; Belongs to the intermediate filament family. (450 aa)
FRAS1Extracellular matrix protein FRAS1. (4066 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2741 aa)
GORABRAB6-interacting golgin isoform X1. (397 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FSTFollistatin isoform X1. (344 aa)
TGM3Protein-glutamine gamma-glutamyltransferase E. (695 aa)
ABCB6ATP-binding cassette sub-family B member 6, mitochondrial. (979 aa)
PNPLA1Patatin-like phospholipase domain-containing protein 1. (565 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (452 aa)
ENSVVUP00000036810annotation not available (68 aa)
OPN3Opsin-3; Belongs to the G-protein coupled receptor 1 family. (419 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2644 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1883 aa)
DHCR24Delta(24)-sterol reductase. (516 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
GRHL3Grainyhead-like protein 3 homolog. (606 aa)
OVOL1Putative transcription factor Ovo-like 1. (267 aa)
RELATranscription factor p65 isoform X2. (542 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (236 aa)
ALX4Homeobox protein aristaless-like 4. (376 aa)
STARD7stAR-related lipid transfer protein 7, mitochondrial. (295 aa)
DSG4Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1058 aa)
KELLOW QUALITY PROTEIN: kell blood group glycoprotein. (750 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (685 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (538 aa)
KRT80Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family. (453 aa)
KRT7Keratin, type II cytoskeletal 7; Belongs to the intermediate filament family. (465 aa)
LOC112921255Keratin, type II microfibrillar, component 7C-like; Belongs to the intermediate filament family. (162 aa)
LOC112920992Keratin, type II cuticular Hb1; Belongs to the intermediate filament family. (513 aa)
LOC112920993Keratin, type II cuticular Hb6; Belongs to the intermediate filament family. (485 aa)
LOC112920994Keratin, type II microfibrillar, component 7C; Belongs to the intermediate filament family. (487 aa)
LOC112921256Keratin, type II cuticular Hb5-like; Belongs to the intermediate filament family. (489 aa)
KRT85Keratin, type II cuticular Hb5 isoform X1; Belongs to the intermediate filament family. (498 aa)
KRT84Keratin, type II cuticular Hb4; Belongs to the intermediate filament family. (592 aa)
COL5A2Collagen alpha-2(V) chain. (1204 aa)
KRT82Keratin, type II cuticular Hb2; Belongs to the intermediate filament family. (509 aa)
LOC112920998Keratin, type II cytoskeletal 5-like; Belongs to the intermediate filament family. (525 aa)
KRT75LOW QUALITY PROTEIN: keratin, type II cytoskeletal 75-like; Belongs to the intermediate filament family. (497 aa)
LOC112920999Keratin, type II cytoskeletal 6A-like; Belongs to the intermediate filament family. (564 aa)
KRT6AKeratin, type II cytoskeletal 6C; Belongs to the intermediate filament family. (564 aa)
KRT5Keratin, type II cytoskeletal 5; Belongs to the intermediate filament family. (591 aa)
KRT71Keratin, type II cytoskeletal 71 isoform X1; Belongs to the intermediate filament family. (525 aa)
KRT74Keratin, type II cytoskeletal 74; Belongs to the intermediate filament family. (553 aa)
KRT72Keratin, type II cytoskeletal 72; Belongs to the intermediate filament family. (510 aa)
KRT73Keratin, type II cytoskeletal 73; Belongs to the intermediate filament family. (540 aa)
KRT77Keratin, type II cytoskeletal 1b-like; Belongs to the intermediate filament family. (586 aa)
LOC112921008Keratin, type II cytoskeletal 3-like; Belongs to the intermediate filament family. (519 aa)
KRT76Keratin, type II cytoskeletal 2 oral-like; Belongs to the intermediate filament family. (592 aa)
KRT3Keratin, type II cytoskeletal 3; Belongs to the intermediate filament family. (629 aa)
KRT4Keratin, type II cytoskeletal 4; Belongs to the intermediate filament family. (527 aa)
KRT79Keratin, type II cytoskeletal 79; Belongs to the intermediate filament family. (538 aa)
KRT78Keratin, type II cytoskeletal 78; Belongs to the intermediate filament family. (545 aa)
KRT8LOW QUALITY PROTEIN: keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (279 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R-type. (699 aa)
HOXC13LOW QUALITY PROTEIN: homeobox protein Hox-C13. (214 aa)
BCL11BB-cell lymphoma/leukemia 11B. (802 aa)
SRFSerum response factor isoform X1. (508 aa)
ENSVVUP00000040567annotation not available (177 aa)
KAZNKazrin isoform X3. (799 aa)
EPHA2Ephrin type-A receptor 2. (921 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K. (843 aa)
SAV1Protein salvador homolog 1. (351 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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