(35 nodes) Lung morphogenesis network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FOXF1	Forkhead box protein F1. (354 aa)
	LIF	Leukemia inhibitory factor. (375 aa)
	CTSH	Pro-cathepsin H; Belongs to the peptidase C1 family. (329 aa)
	HHIP	Hedgehog-interacting protein isoform X2. (727 aa)
	SOX9	LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	YAP1	Transcriptional coactivator YAP1. (431 aa)
	LAMA1	Laminin subunit alpha-1. (2985 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (216 aa)
	ENSVVUP00000017517	annotation not available (118 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (717 aa)
	SPRY1	Protein sprouty homolog 1 isoform X1. (342 aa)
	SPRY2	Protein sprouty homolog 2. (315 aa)
	EXT1	Exostosin-1; Belongs to the glycosyltransferase 47 family. (537 aa)
	KRAS	GTPase KRas isoform X1. (418 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (409 aa)
	DAG1	Dystroglycan. (892 aa)
	SRF	Serum response factor isoform X1. (508 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	DLG5	Disks large homolog 5; Belongs to the MAGUK family. (1825 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2741 aa)
	HOXA5	Homeobox protein Hox-A5. (381 aa)
	PLOD3	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 isoform X2. (739 aa)
	STK40	Serine/threonine-protein kinase 40 isoform X1. (440 aa)
	NODAL	Nodal homolog isoform X1. (348 aa)
	FOXA1	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha. (440 aa)
	NKX2-1	Homeobox protein Nkx-2.1. (369 aa)
	MAPK1	Mitogen-activated protein kinase. (392 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	TCF21	Transcription factor 21. (179 aa)
	TBX2	T-box transcription factor TBX2. (700 aa)
	ENSVVUP00000024290	annotation not available (257 aa)
	SEC24B	LOW QUALITY PROTEIN: protein transport protein Sec24B. (1250 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (278 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSVVUP00000041694	ENSVVUP00000035372	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.786
BMP4	FOXF1	ENSVVUP00000041694	ENSVVUP00000000708	Bone morphogenetic protein 4 isoform X2.	Forkhead box protein F1.	0.473
BMP4	LIF	ENSVVUP00000041694	ENSVVUP00000004444	Bone morphogenetic protein 4 isoform X2.	Leukemia inhibitory factor.	0.550
BMP4	NOG	ENSVVUP00000041694	ENSVVUP00000015880	Bone morphogenetic protein 4 isoform X2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.978
BMP4	SOX9	ENSVVUP00000041694	ENSVVUP00000013114	Bone morphogenetic protein 4 isoform X2.	LOW QUALITY PROTEIN: transcription factor SOX-9.	0.608
BMP4	SPRY2	ENSVVUP00000041694	ENSVVUP00000019273	Bone morphogenetic protein 4 isoform X2.	Protein sprouty homolog 2.	0.440
CTSH	CTSZ	ENSVVUP00000005252	ENSVVUP00000022082	Pro-cathepsin H; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.492
CTSZ	CTSH	ENSVVUP00000022082	ENSVVUP00000005252	Cathepsin Z; Belongs to the peptidase C1 family.	Pro-cathepsin H; Belongs to the peptidase C1 family.	0.492
DAG1	LAMA1	ENSVVUP00000040755	ENSVVUP00000015646	Dystroglycan.	Laminin subunit alpha-1.	0.921
ENSVVUP00000017517	KRAS	ENSVVUP00000017517	ENSVVUP00000042700	annotation not available	GTPase KRas isoform X1.	0.611
ENSVVUP00000024290	KRAS	ENSVVUP00000024290	ENSVVUP00000042700	annotation not available	GTPase KRas isoform X1.	0.611
ENSVVUP00000024290	MAPK1	ENSVVUP00000024290	ENSVVUP00000027843	annotation not available	Mitogen-activated protein kinase.	0.766
FGF10	BMP4	ENSVVUP00000035372	ENSVVUP00000041694	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4 isoform X2.	0.786
FGF10	KRAS	ENSVVUP00000035372	ENSVVUP00000042700	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase KRas isoform X1.	0.633
FGF10	LIF	ENSVVUP00000035372	ENSVVUP00000004444	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Leukemia inhibitory factor.	0.546
FGF10	NKX2-1	ENSVVUP00000035372	ENSVVUP00000028225	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein Nkx-2.1.	0.499
FGF10	NOG	ENSVVUP00000035372	ENSVVUP00000015880	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.603
FGF10	SOX9	ENSVVUP00000035372	ENSVVUP00000013114	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LOW QUALITY PROTEIN: transcription factor SOX-9.	0.534
FOXA1	NKX2-1	ENSVVUP00000028297	ENSVVUP00000028225	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha.	Homeobox protein Nkx-2.1.	0.587
FOXF1	BMP4	ENSVVUP00000000708	ENSVVUP00000041694	Forkhead box protein F1.	Bone morphogenetic protein 4 isoform X2.	0.473