(25 nodes) Lung epithelial cell differentiation network (Vulpes vulpes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	HOXA5	Homeobox protein Hox-A5. (381 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	ENSVVUP00000030260	annotation not available (246 aa)
	FOXA1	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha. (440 aa)
	ENSVVUP00000026625	annotation not available (166 aa)
	NKX2-1	Homeobox protein Nkx-2.1. (369 aa)
	PPP3R2	Calcineurin subunit B type 2. (252 aa)
	ASCL1	Achaete-scute homolog 1. (211 aa)
	AIMP2	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1. (320 aa)
	RBBP9	Putative hydrolase RBBP9. (186 aa)
	NKX2-2	Homeobox protein Nkx-2.2 isoform X1. (273 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	YAP1	Transcriptional coactivator YAP1. (431 aa)
	SOX9	LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
	AGR2	Anterior gradient protein 2 homolog. (195 aa)
	GATA6	Transcription factor GATA-6. (571 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B. (1220 aa)
	KRAS	GTPase KRas isoform X1. (418 aa)
	SAV1	Protein salvador homolog 1. (351 aa)
	THRB	Thyroid hormone receptor beta isoform X2. (510 aa)
	PPP3R1	Calcineurin subunit B type 1. (192 aa)
	TMEM38B	Trimeric intracellular cation channel type B isoform X1. (292 aa)
	SPDEF	SAM pointed domain-containing Ets transcription factor isoform X1. (337 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2153 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	SPDEF	ENSVVUP00000011750	ENSVVUP00000036457	Anterior gradient protein 2 homolog.	SAM pointed domain-containing Ets transcription factor isoform X1.	0.510
ASCL1	CREB1	ENSVVUP00000024445	ENSVVUP00000016172	Achaete-scute homolog 1.	Cyclic AMP-responsive element-binding protein 1 isoform X1.	0.573
ASCL1	NFIB	ENSVVUP00000024445	ENSVVUP00000031352	Achaete-scute homolog 1.	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	0.440
ASCL1	NKX2-1	ENSVVUP00000024445	ENSVVUP00000028225	Achaete-scute homolog 1.	Homeobox protein Nkx-2.1.	0.468
ASCL1	NKX2-2	ENSVVUP00000024445	ENSVVUP00000016528	Achaete-scute homolog 1.	Homeobox protein Nkx-2.2 isoform X1.	0.484
ASCL1	SOX9	ENSVVUP00000024445	ENSVVUP00000013114	Achaete-scute homolog 1.	LOW QUALITY PROTEIN: transcription factor SOX-9.	0.606
CREB1	ASCL1	ENSVVUP00000016172	ENSVVUP00000024445	Cyclic AMP-responsive element-binding protein 1 isoform X1.	Achaete-scute homolog 1.	0.573
ENSVVUP00000026625	SPDEF	ENSVVUP00000026625	ENSVVUP00000036457	annotation not available	SAM pointed domain-containing Ets transcription factor isoform X1.	0.510
FGF10	KRAS	ENSVVUP00000035372	ENSVVUP00000042700	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase KRas isoform X1.	0.633
FGF10	NKX2-1	ENSVVUP00000035372	ENSVVUP00000028225	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein Nkx-2.1.	0.499
FGF10	SOX9	ENSVVUP00000035372	ENSVVUP00000013114	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LOW QUALITY PROTEIN: transcription factor SOX-9.	0.534
FOXA1	GATA6	ENSVVUP00000028297	ENSVVUP00000005020	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha.	Transcription factor GATA-6.	0.823
FOXA1	NKX2-1	ENSVVUP00000028297	ENSVVUP00000028225	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha.	Homeobox protein Nkx-2.1.	0.587
FOXA1	NKX2-2	ENSVVUP00000028297	ENSVVUP00000016528	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha.	Homeobox protein Nkx-2.2 isoform X1.	0.450
GATA6	FOXA1	ENSVVUP00000005020	ENSVVUP00000028297	Transcription factor GATA-6.	LOW QUALITY PROTEIN: hepatocyte nuclear factor 3-alpha.	0.823
GATA6	NKX2-1	ENSVVUP00000005020	ENSVVUP00000028225	Transcription factor GATA-6.	Homeobox protein Nkx-2.1.	0.458
GATA6	SOX9	ENSVVUP00000005020	ENSVVUP00000013114	Transcription factor GATA-6.	LOW QUALITY PROTEIN: transcription factor SOX-9.	0.623
KRAS	FGF10	ENSVVUP00000042700	ENSVVUP00000035372	GTPase KRas isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.633
KRAS	YAP1	ENSVVUP00000042700	ENSVVUP00000014422	GTPase KRas isoform X1.	Transcriptional coactivator YAP1.	0.493
NFIB	ASCL1	ENSVVUP00000031352	ENSVVUP00000024445	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	Achaete-scute homolog 1.	0.440