STRINGSTRING
WDTC1 WDTC1 LOC112912623 LOC112912623 ATP5IF1 ATP5IF1 ETFBKMT ETFBKMT STARD4 STARD4 PDK3 PDK3 DNM1L DNM1L DGKQ DGKQ SLC35B4 SLC35B4 ADIPOQ ADIPOQ PPARGC1A PPARGC1A SLC27A4 SLC27A4 CLYBL CLYBL AVPR1B AVPR1B PTPN2 PTPN2 SLC45A3 SLC45A3 PDK1 PDK1 APOB APOB LOC112934102 LOC112934102 ATP2B4 ATP2B4 PPARG PPARG LEPR LEPR PDK4 PDK4 NOS2 NOS2 ENSVVUP00000021681 ENSVVUP00000021681 PMAIP1 PMAIP1 LONP2 LONP2 NNMT NNMT PPTC7 PPTC7 ABCD2 ABCD2 P2RX7 P2RX7 MLYCD MLYCD FLCN FLCN SREBF1 SREBF1 NCOR1 NCOR1 ACADM ACADM BAD BAD TREX1 TREX1 ABCD1 ABCD1 ENSVVUP00000041731 ENSVVUP00000041731 FAM3A FAM3A ENSVVUP00000041494 ENSVVUP00000041494 HIF1A HIF1A MST1 MST1 GPER1 GPER1 IL1B IL1B LACC1 LACC1 HTR2A HTR2A INSR INSR TP53 TP53 ACADVL ACADVL BCKDK BCKDK GNMT GNMT ENSVVUP00000038628 ENSVVUP00000038628 ARL2 ARL2 WDR5 WDR5 NCS1 NCS1 SLC2A6 SLC2A6 NCOR2 NCOR2 FOXO1 FOXO1 ENSVVUP00000037390 ENSVVUP00000037390 GUCA1B GUCA1B GUCA1A GUCA1A TREM2 TREM2 AKT3 AKT3 ACTN3 ACTN3 PARK7 PARK7 H6PD H6PD NR1H3 NR1H3 PPARD PPARD NUPR1 NUPR1 CLN3 CLN3 KCNMA1 KCNMA1 DKK3 DKK3 APOA4 APOA4 FMO3 FMO3 LOC112923472 LOC112923472 FMO2 FMO2 FMO1 FMO1 PTH PTH FMO4 FMO4 PPARA PPARA ERLIN1 ERLIN1 DNAJC30 DNAJC30 MLXIPL MLXIPL GPD1 GPD1 PANK2 PANK2 LCMT1 LCMT1 BRCA1 BRCA1 STAT3 STAT3 C1QTNF6 C1QTNF6 FIS1 FIS1 BMP2 BMP2 CRY1 CRY1 SPHK2 SPHK2 ABCG4 ABCG4 PDZD3 PDZD3 APPL2 APPL2 HDAC4 HDAC4 PRXL2C PRXL2C TTC39B TTC39B TFF3 TFF3 ABCB11 ABCB11 CYP27B1 CYP27B1 SEC14L5 SEC14L5 GCKR GCKR FAM3C FAM3C SIK1 SIK1 USP7 USP7 SNAI2 SNAI2 SLC4A1 SLC4A1 ATPSCKMT ATPSCKMT LDLR LDLR C1QTNF1 C1QTNF1 CYP7A1 CYP7A1 IGF1 IGF1 TIGAR TIGAR PIBF1 PIBF1 EGR1 EGR1 INSIG2 INSIG2 NR1H4 NR1H4 LOC112935273 LOC112935273 SERPINA12 SERPINA12 NCOA2 NCOA2 POU1F1 POU1F1 SLC7A7 SLC7A7 SIRT1 SIRT1 ERLIN2 ERLIN2 NR1H2 NR1H2 RANBP2 RANBP2 TNF TNF GFI1 GFI1 SIRT4 SIRT4 GIT1 GIT1 FGF1 FGF1 KAT2A KAT2A SLC7A11 SLC7A11 TYSND1 TYSND1 ZBTB20 ZBTB20 SNAI1 SNAI1 DDIT4 DDIT4 DKKL1 DKKL1 FBP1 FBP1 MIDN MIDN PID1 PID1 OGT OGT SIRT7 SIRT7 KAT2B KAT2B IGFBP4 IGFBP4 ELOVL5 ELOVL5 TSPO TSPO NR1D1 NR1D1 FGFR4 FGFR4 BMP5 BMP5 PRKN PRKN PRKN-2 PRKN-2 LOC112921570 LOC112921570 PARP1 PARP1 SCAP SCAP RORA RORA GUCA2A GUCA2A GUCA2B GUCA2B ENSVVUP00000003074 ENSVVUP00000003074 PLA2G3 PLA2G3 LOC112912760 LOC112912760 GPLD1 GPLD1 INS INS INSIG1 INSIG1 SEC14L4 SEC14L4 SEC14L3 SEC14L3 SEC14L2 SEC14L2 AKT1 AKT1 ANXA1 ANXA1 GIP GIP PTK2B PTK2B CBFA2T3 CBFA2T3 SIRT5 SIRT5 EIF6 EIF6 C1QTNF12 C1QTNF12 PDK2 PDK2 ATCAY ATCAY LOC112928185 LOC112928185 BEND3 BEND3 FGF19 FGF19 BMP6 BMP6 DDB1 DDB1 ZMPSTE24 ZMPSTE24 MFSD2A MFSD2A FOXK2 FOXK2 PRKCE PRKCE ZNF692 ZNF692 LHCGR LHCGR TTC39A TTC39A REST REST FOXK1 FOXK1 ENSVVUP00000008051 ENSVVUP00000008051 ACMSD ACMSD LOC112923739 LOC112923739 MAS1 MAS1 ADIPOR1 ADIPOR1 ENSVVUP00000008924 ENSVVUP00000008924 EP300 EP300 ARV1 ARV1 CD74 CD74 FMO5 FMO5 PRKAG2 PRKAG2 ENSVVUP00000010162 ENSVVUP00000010162 EPM2AIP1 EPM2AIP1 PROX1 PROX1 SIRT6 SIRT6 TRIB3 TRIB3 APOC2 APOC2 APOE APOE NOS3 NOS3 GCK GCK PLIN5 PLIN5 ENSVVUP00000011849 ENSVVUP00000011849 PGP PGP SOX9 SOX9 RD3 RD3 LPGAT1 LPGAT1 DUSP12 DUSP12 LOC112914568 LOC112914568 PRMT3 PRMT3 IFNG IFNG DYRK2 DYRK2 CYP27C1 CYP27C1 CAV1 CAV1 LPCAT3 LPCAT3 MALRD1 MALRD1 MID1IP1 MID1IP1 COX11 COX11 CLCN2 CLCN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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WDTC1WD and tetratricopeptide repeats protein 1 isoform X1. (679 aa)
LOC112912623Coiled-coil domain-containing protein 144B-like. (1459 aa)
ATP5IF1ATPase inhibitor, mitochondrial. (106 aa)
ETFBKMTElectron transfer flavoprotein beta subunit lysine methyltransferase. (266 aa)
STARD4stAR-related lipid transfer protein 4 isoform X1. (208 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
DGKQDiacylglycerol kinase. (865 aa)
SLC35B4UDP-xylose and UDP-N-acetylglucosamine transporter. (331 aa)
ADIPOQAdiponectin. (266 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (817 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
CLYBLcitramalyl-CoA lyase, mitochondrial isoform X1. (377 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
PDK1Protein-serine/threonine kinase. (407 aa)
APOBApolipoprotein B-100. (4347 aa)
LOC112934102General transcription factor II-I repeat domain-containing protein 2 isoform X1. (565 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
LEPRLeptin receptor isoform X1. (1172 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
ENSVVUP00000021681annotation not available (357 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (141 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
PPTC7Protein phosphatase; Belongs to the PP2C family. (304 aa)
ABCD2ATP-binding cassette sub-family D member 2. (742 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
MLYCDmalonyl-CoA decarboxylase, mitochondrial. (479 aa)
FLCNFolliculin. (935 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X3. (1152 aa)
NCOR1Nuclear receptor corepressor 1 isoform X5. (2521 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial. (423 aa)
BADBcl2-associated agonist of cell death. (157 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
ABCD1ATP-binding cassette sub-family D member 1. (516 aa)
ENSVVUP00000041731annotation not available (218 aa)
FAM3AProtein FAM3A isoform X1. (330 aa)
ENSVVUP00000041494annotation not available (120 aa)
HIF1AHypoxia-inducible factor 1-alpha. (764 aa)
MST1Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
LACC1Laccase domain-containing protein 1 isoform X2. (349 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial. (555 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
GNMTGlycine N-methyltransferase. (295 aa)
ENSVVUP00000038628annotation not available (69 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform X3; Belongs to the small GTPase superfamily. Arf family. (184 aa)
WDR5WD repeat-containing protein 5. (334 aa)
NCS1Neuronal calcium sensor 1. (194 aa)
SLC2A6Solute carrier family 2, facilitated glucose transporter member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (653 aa)
NCOR2Nuclear receptor corepressor 2 isoform X9. (2529 aa)
FOXO1Forkhead box protein O1. (670 aa)
ENSVVUP00000037390annotation not available (101 aa)
GUCA1BGuanylyl cyclase-activating protein 2. (201 aa)
GUCA1AGuanylyl cyclase-activating protein 1. (205 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X1. (404 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ACTN3Alpha-actinin-3 isoform X1. (1024 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein isoform X2. (797 aa)
NR1H3Oxysterols receptor LXR-alpha. (447 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
NUPR1Nuclear protein 1. (82 aa)
CLN3Battenin. (438 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X1. (1133 aa)
DKK3Dickkopf-related protein 3. (357 aa)
APOA4Apolipoprotein A-IV. (388 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
LOC112923472Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
FMO1Flavin-containing monooxygenase. (558 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (555 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
ERLIN1Erlin-1. (346 aa)
DNAJC30dnaJ homolog subfamily C member 30. (182 aa)
MLXIPLCarbohydrate-responsive element-binding protein isoform X1. (907 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (348 aa)
PANK2Pantothenate kinase 2, mitochondrial isoform X2. (449 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (333 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1891 aa)
STAT3Signal transducer and activator of transcription. (791 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (268 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
CRY1Cryptochrome-1. (596 aa)
SPHK2Sphingosine kinase 2 isoform X1. (674 aa)
ABCG4ATP-binding cassette sub-family G member 4. (646 aa)
PDZD3Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X3. (493 aa)
APPL2DCC-interacting protein 13-beta isoform X2. (695 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1180 aa)
PRXL2CThioredoxin-like protein AAED1. (228 aa)
TTC39BTetratricopeptide repeat protein 39B isoform X1. (591 aa)
TFF3Trefoil factor 3. (102 aa)
ABCB11Bile salt export pump. (1267 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
SEC14L5SEC14-like protein 5 isoform X1. (695 aa)
GCKRGlucokinase regulatory protein isoform X2. (600 aa)
FAM3CProtein FAM3C. (227 aa)
SIK1Serine/threonine-protein kinase SIK1. (773 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1164 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
SLC4A1Anion exchange protein. (883 aa)
ATPSCKMTProtein N-lysine methyltransferase FAM173B. (318 aa)
LDLRLow-density lipoprotein receptor. (866 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1 isoform X1. (393 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (270 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (1111 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
NR1H4Bile acid receptor isoform X2. (481 aa)
LOC112935273Tetratricopeptide repeat protein 39B-like. (591 aa)
SERPINA12Serpin A12-like; Belongs to the serpin family. (414 aa)
NCOA2Nuclear receptor coactivator. (1485 aa)
POU1F1POU domain protein. (370 aa)
SLC7A7Y+L amino acid transporter 1. (542 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (769 aa)
ERLIN2Erlin-2 isoform X1. (353 aa)
NR1H2Oxysterols receptor LXR-beta. (457 aa)
RANBP2E3 SUMO-protein ligase RanBP2 isoform X4. (3265 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
GFI1LOW QUALITY PROTEIN: zinc finger protein Gfi-1. (410 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (313 aa)
GIT1ARF GTPase-activating protein GIT1. (798 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (903 aa)
SLC7A11Cystine/glutamate transporter. (503 aa)
TYSND1Trypsin domain containing 1. (673 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (741 aa)
SNAI1Zinc finger protein SNAI1 isoform X1. (264 aa)
DDIT4DNA damage-inducible transcript 4 protein. (230 aa)
DKKL1Dickkopf-like protein 1 isoform X1. (318 aa)
FBP1Fructose-1,6-bisphosphatase 1 isoform X1; Belongs to the FBPase class 1 family. (341 aa)
MIDNMidnolin. (451 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein isoform X1. (243 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (475 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (799 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (336 aa)
TSPOTranslocator protein. (169 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (617 aa)
FGFR4Fibroblast growth factor receptor. (844 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (381 aa)
PRKN-2E3 ubiquitin-protein ligase parkin. (176 aa)
LOC112921570Ankyrin repeat domain-containing protein 26-like isoform X1. (1689 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein. (1161 aa)
RORANuclear receptor ROR-alpha. (473 aa)
GUCA2AGuanylin. (111 aa)
GUCA2BGuanylate cyclase activator 2B. (124 aa)
ENSVVUP00000003074annotation not available (314 aa)
PLA2G3LOW QUALITY PROTEIN: group 3 secretory phospholipase A2. (512 aa)
LOC112912760Ankyrin repeat domain-containing protein 26-like. (201 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (853 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (303 aa)
SEC14L4SEC14-like protein 4. (406 aa)
SEC14L3SEC14-like protein 3. (491 aa)
SEC14L2SEC14-like protein 2 isoform X2. (482 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ANXA1Annexin. (345 aa)
GIPGastric inhibitory polypeptide. (160 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CBFA2T3Protein CBFA2T3. (608 aa)
SIRT5Sirtuin 5. (315 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
C1QTNF12Adipolin. (297 aa)
PDK2Protein-serine/threonine kinase. (408 aa)
ATCAYCaytaxin. (411 aa)
LOC112928185NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (266 aa)
BEND3BEN domain-containing protein 3. (831 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
BMP6Bone morphogenetic protein 6. (418 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1. (523 aa)
FOXK2LOW QUALITY PROTEIN: forkhead box protein K2. (622 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (750 aa)
ZNF692LOW QUALITY PROTEIN: zinc finger protein 692. (519 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (663 aa)
TTC39ALOW QUALITY PROTEIN: tetratricopeptide repeat protein 39A. (623 aa)
RESTRE1-silencing transcription factor. (996 aa)
FOXK1Forkhead box protein K1. (611 aa)
ENSVVUP00000008051annotation not available (74 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
LOC112923739LOW QUALITY PROTEIN: fatty acid-binding protein 5. (104 aa)
MAS1Proto-oncogene Mas; Belongs to the G-protein coupled receptor 1 family. (325 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
ENSVVUP00000008924annotation not available (159 aa)
EP300Histone acetyltransferase p300 isoform X1. (2430 aa)
ARV1Protein ARV1. (281 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (272 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (257 aa)
ENSVVUP00000010162annotation not available (285 aa)
EPM2AIP1EPM2A-interacting protein 1. (608 aa)
PROX1Prospero homeobox protein 1 isoform X2. (737 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X1. (330 aa)
TRIB3Tribbles homolog 3. (358 aa)
APOC2Apolipoprotein C-II isoform X1. (101 aa)
APOEApolipoprotein E. (336 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1207 aa)
GCKPhosphotransferase. (481 aa)
PLIN5Perilipin; Belongs to the perilipin family. (499 aa)
ENSVVUP00000011849annotation not available (98 aa)
PGPGlycerol-3-phosphate phosphatase; Belongs to the HAD-like hydrolase superfamily. (308 aa)
SOX9LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
RD3Protein RD3. (99 aa)
LPGAT1acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1. (486 aa)
DUSP12LOW QUALITY PROTEIN: dual specificity protein phosphatase 12. (305 aa)
LOC112914568Dimethylaniline monooxygenase [N-oxide-forming]. (617 aa)
PRMT3Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (564 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (593 aa)
CYP27C1Cytochrome P450 27C1 isoform X2; Belongs to the cytochrome P450 family. (492 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (524 aa)
MALRD1LOW QUALITY PROTEIN: MAM and LDL-receptor class A domain-containing protein 1. (335 aa)
MID1IP1Mid1-interacting protein 1. (183 aa)
COX11Cytochrome c oxidase assembly protein COX11, mitochondrial. (291 aa)
CLCN2Chloride channel protein. (928 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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