node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL2 | ATM | ENSVVUP00000017090 | ENSVVUP00000020826 | Tyrosine-protein kinase. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.765 |
ABL2 | YAP1 | ENSVVUP00000017090 | ENSVVUP00000014422 | Tyrosine-protein kinase. | Transcriptional coactivator YAP1. | 0.508 |
ALDH1A2 | CYP26B1 | ENSVVUP00000001570 | ENSVVUP00000009626 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | 0.942 |
ATM | ABL2 | ENSVVUP00000020826 | ENSVVUP00000017090 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Tyrosine-protein kinase. | 0.765 |
ATM | GSK3B | ENSVVUP00000020826 | ENSVVUP00000030506 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. | 0.426 |
CREB1 | GSK3B | ENSVVUP00000016172 | ENSVVUP00000030506 | Cyclic AMP-responsive element-binding protein 1 isoform X1. | Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. | 0.710 |
CYP26B1 | ALDH1A2 | ENSVVUP00000009626 | ENSVVUP00000001570 | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | 0.942 |
CYP26B1 | SOX9 | ENSVVUP00000009626 | ENSVVUP00000013114 | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | LOW QUALITY PROTEIN: transcription factor SOX-9. | 0.452 |
CYP26B1 | STRA8 | ENSVVUP00000009626 | ENSVVUP00000007801 | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | Stimulated by retinoic acid 8. | 0.607 |
GSK3B | ATM | ENSVVUP00000030506 | ENSVVUP00000020826 | Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.426 |
GSK3B | CREB1 | ENSVVUP00000030506 | ENSVVUP00000016172 | Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. | Cyclic AMP-responsive element-binding protein 1 isoform X1. | 0.710 |
HTRA2 | NDUFA13 | ENSVVUP00000005305 | ENSVVUP00000010183 | Serine protease HTRA2, mitochondrial. | NADH:ubiquinone oxidoreductase subunit A13. | 0.435 |
HTRA2 | YJEFN3 | ENSVVUP00000005305 | ENSVVUP00000010164 | Serine protease HTRA2, mitochondrial. | yjeF N-terminal domain-containing protein 3 isoform X2. | 0.435 |
LYN | PTK2B | ENSVVUP00000024334 | ENSVVUP00000004525 | Tyrosine-protein kinase. | Protein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.970 |
LYN | RET | ENSVVUP00000024334 | ENSVVUP00000029131 | Tyrosine-protein kinase. | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | 0.406 |
NDUFA13 | HTRA2 | ENSVVUP00000010183 | ENSVVUP00000005305 | NADH:ubiquinone oxidoreductase subunit A13. | Serine protease HTRA2, mitochondrial. | 0.435 |
PTK2B | LYN | ENSVVUP00000004525 | ENSVVUP00000024334 | Protein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Tyrosine-protein kinase. | 0.970 |
RET | LYN | ENSVVUP00000029131 | ENSVVUP00000024334 | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | Tyrosine-protein kinase. | 0.406 |
SOX9 | CYP26B1 | ENSVVUP00000013114 | ENSVVUP00000009626 | LOW QUALITY PROTEIN: transcription factor SOX-9. | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | 0.452 |
STRA8 | CYP26B1 | ENSVVUP00000007801 | ENSVVUP00000009626 | Stimulated by retinoic acid 8. | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | 0.607 |