(19 nodes) Cellular response to interleukin-4 network (Vulpes vulpes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	PML	Protein PML. (406 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (903 aa)
	STAT6	Signal transducer and activator of transcription. (842 aa)
	TCF7	LOW QUALITY PROTEIN: transcription factor 7. (517 aa)
	NFIL3	Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
	ENSVVUP00000034241	annotation not available (129 aa)
	XBP1	LOW QUALITY PROTEIN: X-box-binding protein 1. (227 aa)
	SHPK	Sedoheptulokinase isoform X1. (521 aa)
	ALAD	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
	MRC1	Macrophage mannose receptor 1. (1475 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (501 aa)
	FASN	Fatty acid synthase. (2516 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
	RUFY4	RUN and FYVE domain-containing protein 4. (578 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family. (654 aa)
	JAK3	Tyrosine-protein kinase. (1106 aa)
	DCSTAMP	Dendritic cell-specific transmembrane protein. (470 aa)
	KEAP1	Kelch-like ECH-associated protein 1. (624 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X3. (468 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALAD	FASN	ENSVVUP00000004147	ENSVVUP00000006584	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	Fatty acid synthase.	0.749
ENSVVUP00000034241	GATA3	ENSVVUP00000034241	ENSVVUP00000008669	annotation not available	Trans-acting T-cell-specific transcription factor GATA-3.	0.427
FASN	ALAD	ENSVVUP00000006584	ENSVVUP00000004147	Fatty acid synthase.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.749
GATA3	ENSVVUP00000034241	ENSVVUP00000008669	ENSVVUP00000034241	Trans-acting T-cell-specific transcription factor GATA-3.	annotation not available	0.427
GATA3	LEF1	ENSVVUP00000008669	ENSVVUP00000023803	Trans-acting T-cell-specific transcription factor GATA-3.	Lymphoid enhancer-binding factor 1 isoform X3.	0.516
GATA3	NFIL3	ENSVVUP00000008669	ENSVVUP00000030601	Trans-acting T-cell-specific transcription factor GATA-3.	Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]	0.427
GATA3	STAT6	ENSVVUP00000008669	ENSVVUP00000026225	Trans-acting T-cell-specific transcription factor GATA-3.	Signal transducer and activator of transcription.	0.736
GATA3	TCF7	ENSVVUP00000008669	ENSVVUP00000029284	Trans-acting T-cell-specific transcription factor GATA-3.	LOW QUALITY PROTEIN: transcription factor 7.	0.440
HSPA5	XBP1	ENSVVUP00000013744	ENSVVUP00000035892	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	LOW QUALITY PROTEIN: X-box-binding protein 1.	0.809
JAK3	STAT6	ENSVVUP00000013982	ENSVVUP00000026225	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.989
LEF1	GATA3	ENSVVUP00000023803	ENSVVUP00000008669	Lymphoid enhancer-binding factor 1 isoform X3.	Trans-acting T-cell-specific transcription factor GATA-3.	0.516
LEF1	TCF7	ENSVVUP00000023803	ENSVVUP00000029284	Lymphoid enhancer-binding factor 1 isoform X3.	LOW QUALITY PROTEIN: transcription factor 7.	0.627
NFIL3	GATA3	ENSVVUP00000030601	ENSVVUP00000008669	Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]	Trans-acting T-cell-specific transcription factor GATA-3.	0.427
STAT6	GATA3	ENSVVUP00000026225	ENSVVUP00000008669	Signal transducer and activator of transcription.	Trans-acting T-cell-specific transcription factor GATA-3.	0.736
STAT6	JAK3	ENSVVUP00000026225	ENSVVUP00000013982	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.989
TCF7	GATA3	ENSVVUP00000029284	ENSVVUP00000008669	LOW QUALITY PROTEIN: transcription factor 7.	Trans-acting T-cell-specific transcription factor GATA-3.	0.440
TCF7	LEF1	ENSVVUP00000029284	ENSVVUP00000023803	LOW QUALITY PROTEIN: transcription factor 7.	Lymphoid enhancer-binding factor 1 isoform X3.	0.627
XBP1	HSPA5	ENSVVUP00000035892	ENSVVUP00000013744	LOW QUALITY PROTEIN: X-box-binding protein 1.	Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family.	0.809