(37 nodes) Multivesicular body sorting pathway network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	RAB27A	Ras-related protein Rab-27A. (221 aa)
	CHMP4C	Charged multivesicular body protein 4c. (236 aa)
	SORT1	Sortilin. (764 aa)
	CHMP2A	Charged multivesicular body protein 2a isoform X2. (222 aa)
	PTPN23	Tyrosine-protein phosphatase non-receptor type 23. (1646 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	CHMP1A	Charged multivesicular body protein 1a. (210 aa)
	STAM	Signal transducing adapter molecule 1 isoform X1. (538 aa)
	VTA1	Vacuolar protein sorting-associated protein VTA1 homolog isoform X1. (306 aa)
	CHMP4B	Charged multivesicular body protein 4b. (224 aa)
	SYTL4	Synaptotagmin-like protein 4 isoform X1. (671 aa)
	CHMP7	Charged multivesicular body protein 7. (450 aa)
	VPS28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (221 aa)
	UBXN6	UBX domain-containing protein 6. (471 aa)
	LYST	Lysosomal-trafficking regulator isoform X2. (3801 aa)
	LAPTM4B	Lysosomal-associated transmembrane protein 4B isoform X1. (245 aa)
	DENND10	Protein FAM45A isoform X1. (642 aa)
	LEPROT	Leptin receptor gene-related protein isoform X1. (160 aa)
	LAPTM4A	Lysosomal-associated transmembrane protein 4A. (281 aa)
	RAB27B	Ras-related protein Rab-27B. (260 aa)
	EXPH5	Exophilin-5 isoform X1. (2087 aa)
	MVB12A	Multivesicular body subunit 12A isoform X1. (298 aa)
	VPS4B	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (461 aa)
	CHMP6	Charged multivesicular body protein 6. (184 aa)
	CHMP2B	Charged multivesicular body protein 2b. (221 aa)
	LEPROTL1	Leptin receptor overlapping transcript-like 1. (144 aa)
	CHMP5	Charged multivesicular body protein 5. (288 aa)
	RILP	Rab-interacting lysosomal protein. (357 aa)
	PDCD6IP	Programmed cell death 6-interacting protein isoform X2. (869 aa)
	TMEM50B	Transmembrane protein 50B. (168 aa)
	VPS25	Vacuolar protein-sorting-associated protein 25. (176 aa)
	ENSVVUP00000034315	annotation not available (59 aa)
	VCP	Transitional endoplasmic reticulum ATPase isoform X1; Belongs to the AAA ATPase family. (839 aa)
	VPS36	Vacuolar protein-sorting-associated protein 36 isoform X2. (367 aa)
	TMEM50A	Transmembrane protein 50A. (157 aa)
	CHMP3	Charged multivesicular body protein 3 isoform X2. (249 aa)
	CHMP4A	Charged multivesicular body protein 4a isoform X2. (222 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP1A	CHMP2A	ENSVVUP00000004967	ENSVVUP00000004080	Charged multivesicular body protein 1a.	Charged multivesicular body protein 2a isoform X2.	0.997
CHMP1A	CHMP2B	ENSVVUP00000004967	ENSVVUP00000026088	Charged multivesicular body protein 1a.	Charged multivesicular body protein 2b.	0.978
CHMP1A	CHMP3	ENSVVUP00000004967	ENSVVUP00000040288	Charged multivesicular body protein 1a.	Charged multivesicular body protein 3 isoform X2.	0.971
CHMP1A	CHMP4A	ENSVVUP00000004967	ENSVVUP00000040968	Charged multivesicular body protein 1a.	Charged multivesicular body protein 4a isoform X2.	0.538
CHMP1A	CHMP4B	ENSVVUP00000004967	ENSVVUP00000005846	Charged multivesicular body protein 1a.	Charged multivesicular body protein 4b.	0.903
CHMP1A	CHMP4C	ENSVVUP00000004967	ENSVVUP00000001415	Charged multivesicular body protein 1a.	Charged multivesicular body protein 4c.	0.912
CHMP1A	CHMP5	ENSVVUP00000004967	ENSVVUP00000028868	Charged multivesicular body protein 1a.	Charged multivesicular body protein 5.	0.942
CHMP1A	CHMP6	ENSVVUP00000004967	ENSVVUP00000025291	Charged multivesicular body protein 1a.	Charged multivesicular body protein 6.	0.710
CHMP1A	CHMP7	ENSVVUP00000004967	ENSVVUP00000006564	Charged multivesicular body protein 1a.	Charged multivesicular body protein 7.	0.777
CHMP1A	ENSVVUP00000034315	ENSVVUP00000004967	ENSVVUP00000034315	Charged multivesicular body protein 1a.	annotation not available	0.565
CHMP1A	MVB12A	ENSVVUP00000004967	ENSVVUP00000021912	Charged multivesicular body protein 1a.	Multivesicular body subunit 12A isoform X1.	0.651
CHMP1A	PDCD6IP	ENSVVUP00000004967	ENSVVUP00000030217	Charged multivesicular body protein 1a.	Programmed cell death 6-interacting protein isoform X2.	0.431
CHMP1A	SNF8	ENSVVUP00000004967	ENSVVUP00000004362	Charged multivesicular body protein 1a.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.710
CHMP1A	STAM	ENSVVUP00000004967	ENSVVUP00000005086	Charged multivesicular body protein 1a.	Signal transducing adapter molecule 1 isoform X1.	0.497
CHMP1A	VPS25	ENSVVUP00000004967	ENSVVUP00000033010	Charged multivesicular body protein 1a.	Vacuolar protein-sorting-associated protein 25.	0.708
CHMP1A	VPS28	ENSVVUP00000004967	ENSVVUP00000007862	Charged multivesicular body protein 1a.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.727
CHMP1A	VPS36	ENSVVUP00000004967	ENSVVUP00000037450	Charged multivesicular body protein 1a.	Vacuolar protein-sorting-associated protein 36 isoform X2.	0.664
CHMP1A	VPS4B	ENSVVUP00000004967	ENSVVUP00000024231	Charged multivesicular body protein 1a.	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family.	0.992
CHMP1A	VTA1	ENSVVUP00000004967	ENSVVUP00000005772	Charged multivesicular body protein 1a.	Vacuolar protein sorting-associated protein VTA1 homolog isoform X1.	0.997
CHMP2A	CHMP1A	ENSVVUP00000004080	ENSVVUP00000004967	Charged multivesicular body protein 2a isoform X2.	Charged multivesicular body protein 1a.	0.997