STRINGSTRING
IRX2 IRX2 HES1 HES1 GREM1 GREM1 HES5 HES5 PAX8 PAX8 LAMB2 LAMB2 BMP4 BMP4 KIF26B KIF26B LGR4 LGR4 GDNF GDNF PKD2 PKD2 PKD1 PKD1 SOX9 SOX9 SOX8 SOX8 SMO SMO NPHS2 NPHS2 PDGFB PDGFB OSR1 OSR1 WT1 WT1 LHX1 LHX1 TCF21 TCF21 ENSVVUP00000026399 ENSVVUP00000026399 SALL1 SALL1 AQP1 AQP1 PDGFRA PDGFRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRX2Iroquois-class homeodomain protein IRX-2. (346 aa)
HES1Transcription factor HES-1. (282 aa)
GREM1Gremlin. (184 aa)
HES5Transcription factor HES-5. (139 aa)
PAX8Paired box protein Pax-8 isoform X3. (459 aa)
LAMB2Laminin subunit beta-2 isoform X2. (1850 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (409 aa)
KIF26BKinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2015 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (955 aa)
GDNFGlial cell line-derived neurotrophic factor. (198 aa)
PKD2Polycystin-2. (869 aa)
PKD1Polycystin-1. (3467 aa)
SOX9LOW QUALITY PROTEIN: transcription factor SOX-9. (445 aa)
SOX8Transcription factor SOX-8. (480 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (802 aa)
NPHS2Podocin. (268 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
OSR1LOW QUALITY PROTEIN: protein odd-skipped-related 1. (294 aa)
WT1Wilms tumor protein isoform X2. (514 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
TCF21Transcription factor 21. (179 aa)
ENSVVUP00000026399annotation not available (144 aa)
SALL1Sal-like protein 1 isoform X1. (1202 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (283 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1111 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.