STRINGSTRING
RGS14 RGS14 SORCS2 SORCS2 LIN7C LIN7C FMR1 FMR1 ADGRA1 ADGRA1 ADAM22 ADAM22 GRM3 GRM3 ADAM10 ADAM10 ENSVVUP00000002079 ENSVVUP00000002079 AKAP7 AKAP7 CPEB4 CPEB4 PLEKHA5 PLEKHA5 CALB1 CALB1 ABHD17A ABHD17A SRCIN1 SRCIN1 EPS8 EPS8 CAP2 CAP2 DTNBP1 DTNBP1 PSD PSD NGFR NGFR ABHD17B ABHD17B SYNJ2BP SYNJ2BP SAMD14 SAMD14 PPP1R9B PPP1R9B PTPRO PTPRO DVL1 DVL1 KALRN KALRN SHANK2 SHANK2 NEURL1 NEURL1 GRIN2B GRIN2B ABHD17C ABHD17C DAGLA DAGLA GRM1 GRM1 STXBP5 STXBP5 HOMER2 HOMER2 GRIA1 GRIA1 SORCS3 SORCS3 ARHGEF9 ARHGEF9 CACNG3 CACNG3 RGS7BP RGS7BP CRIPT CRIPT TMEM108 TMEM108 SYT11 SYT11 LOC112923739 LOC112923739 LRFN1 LRFN1 EEF2K EEF2K FXR1 FXR1 CACNG4 CACNG4 CACNG5 CACNG5 SHISA7 SHISA7 DISC1 DISC1 DMTN DMTN ENSVVUP00000009671 ENSVVUP00000009671 GRID2 GRID2 SYNPO SYNPO LOC112908207 LOC112908207 MAP1B MAP1B LRRC4 LRRC4 RGS9 RGS9 HOMER3 HOMER3 ADD3 ADD3 DBNL DBNL CACNG8 CACNG8 CACNG7 CACNG7 CDK5 CDK5 FBXO45 FBXO45 PAK2 PAK2 ENSVVUP00000011849 ENSVVUP00000011849 LRRC7 LRRC7 LOC112910522 LOC112910522 PDPK1 PDPK1 ERBB4 ERBB4 TSC2 TSC2 RTN4 RTN4 GRIN2C GRIN2C SYT12 SYT12 LRFN4 LRFN4 LIN7A LIN7A CLSTN3 CLSTN3 PAK3 PAK3 EIF3A EIF3A ITPR1 ITPR1 ENSVVUP00000015434 ENSVVUP00000015434 ITPR1-2 ITPR1-2 SHANK1 SHANK1 LRRC4B LRRC4B RNF19A RNF19A LRFN5 LRFN5 RAPGEF4 RAPGEF4 DNAJC6 DNAJC6 RS1 RS1 DCC DCC ENSVVUP00000020942 ENSVVUP00000020942 PDE4B PDE4B GRIK2 GRIK2 PPP1R9A PPP1R9A NETO2 NETO2 ENSVVUP00000021885 ENSVVUP00000021885 SLC30A3 SLC30A3 USP8 USP8 USP50 USP50 ADCY8 ADCY8 P2RX3 P2RX3 DLG2-2 DLG2-2 MPP2 MPP2 DNM2 DNM2 GRIN2A GRIN2A ENSVVUP00000024337 ENSVVUP00000024337 CTNND2 CTNND2 LOC112934252 LOC112934252 LRRC4C LRRC4C BMPR2 BMPR2 ALS2 ALS2 ENSVVUP00000025132 ENSVVUP00000025132 NPTN NPTN INSYN1 INSYN1 ENSVVUP00000025272 ENSVVUP00000025272 NETO1 NETO1 GRM5 GRM5 BCR BCR SHISA9 SHISA9 ENSVVUP00000026460 ENSVVUP00000026460 PCLO PCLO SLITRK1 SLITRK1 PKP4 PKP4 NRGN NRGN GRIK4 GRIK4 SIGMAR1 SIGMAR1 CABP1 CABP1 PDZD2 PDZD2 GAP43 GAP43 ENSVVUP00000030418 ENSVVUP00000030418 DROSHA DROSHA SYNDIG1 SYNDIG1 KPNA1 KPNA1 SCRIB SCRIB PRR12 PRR12 NTRK2 NTRK2 ATP2B2 ATP2B2 PALM PALM PLCB4 PLCB4 LIN7B LIN7B GRIN2D GRIN2D SLC8A2 SLC8A2 CACNG2 CACNG2 CAMK1 CAMK1 ADD1 ADD1 PICK1 PICK1 GSG1L GSG1L RPS3 RPS3 CLSTN1 CLSTN1 BACE1 BACE1 PRRT1 PRRT1 HOMER1 HOMER1 CADM1 CADM1 DGCR8 DGCR8 LZTS3 LZTS3 DLG5 DLG5 SYNGAP1 SYNGAP1 MAPK8IP2 MAPK8IP2 SHANK3 SHANK3 GRID1 GRID1 ENSVVUP00000036027 ENSVVUP00000036027 DBN1 DBN1 CLSTN2 CLSTN2 LRFN2 LRFN2 DCLK1 DCLK1 DCLK1-2 DCLK1-2 ENSVVUP00000037390 ENSVVUP00000037390 NCS1 NCS1 DLG4 DLG4 FXR2 FXR2 ATP1B2 ATP1B2 EFNB3 EFNB3 SYT9 SYT9 AKAP5 AKAP5 ADD2 ADD2 TSC1 TSC1 SEMA4C SEMA4C GPER1 GPER1 BSN BSN GRIN1 GRIN1 CAMK2N1 CAMK2N1 SH2D5 SH2D5 ADCY1 ADCY1 RTN3 RTN3 GNG3 GNG3 SHISA6 SHISA6 ENSVVUP00000042010 ENSVVUP00000042010 ARHGAP44 ARHGAP44 SLITRK3 SLITRK3 RNF112 RNF112
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RGS14Regulator of G-protein signaling 14 isoform X1. (584 aa)
SORCS2VPS10 domain-containing receptor SorCS2. (987 aa)
LIN7CProtein lin-7 homolog C. (259 aa)
FMR1Synaptic functional regulator FMR1 isoform X1. (599 aa)
ADGRA1Adhesion G protein-coupled receptor A1; Belongs to the G-protein coupled receptor 2 family. (565 aa)
ADAM22Disintegrin and metalloproteinase domain-containing protein 22 isoform X15. (785 aa)
GRM3Metabotropic glutamate receptor 3. (879 aa)
ADAM10Disintegrin and metalloproteinase domain-containing protein 10. (747 aa)
ENSVVUP00000002079annotation not available (83 aa)
AKAP7A-kinase anchoring protein 7 isoform X1. (360 aa)
CPEB4Cytoplasmic polyadenylation element-binding protein 4 isoform X1. (729 aa)
PLEKHA5Pleckstrin homology domain-containing family A member 5 isoform X4. (1078 aa)
CALB1Calbindin. (314 aa)
ABHD17AAlpha/beta hydrolase domain-containing protein 17A. (310 aa)
SRCIN1LOW QUALITY PROTEIN: SRC kinase signaling inhibitor 1. (1501 aa)
EPS8Epidermal growth factor receptor kinase substrate 8 isoform X1. (861 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (497 aa)
DTNBP1Dysbindin. (360 aa)
PSDPH and SEC7 domain-containing protein 1 isoform X1. (1028 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (423 aa)
ABHD17BAlpha/beta hydrolase domain-containing protein 17B. (291 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
SAMD14Sterile alpha motif domain-containing protein 14 isoform X1. (405 aa)
PPP1R9BNeurabin-2. (776 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1233 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
KALRNKalirin isoform X10. (1654 aa)
SHANK2SH3 and multiple ankyrin repeat domains protein 2. (1828 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1. (573 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1513 aa)
ABHD17CAlpha/beta hydrolase domain-containing protein 17C. (303 aa)
DAGLASn1-specific diacylglycerol lipase alpha. (1042 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1190 aa)
STXBP5Syntaxin-binding protein 5 isoform X1. (1179 aa)
HOMER2Homer protein homolog 2. (370 aa)
GRIA1Glutamate receptor 1. (899 aa)
SORCS3VPS10 domain-containing receptor SorCS3. (1187 aa)
ARHGEF9Rho guanine nucleotide exchange factor 9 isoform X4. (553 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
RGS7BPRegulator of G-protein signaling 7-binding protein isoform X1. (257 aa)
CRIPTCysteine-rich PDZ-binding protein. (411 aa)
TMEM108Transmembrane protein 108. (581 aa)
SYT11Synaptotagmin-11. (431 aa)
LOC112923739LOW QUALITY PROTEIN: fatty acid-binding protein 5. (104 aa)
LRFN1LOW QUALITY PROTEIN: leucine-rich repeat and fibronectin type III domain-containing protein 1. (662 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
FXR1Fragile X mental retardation syndrome-related protein 1 isoform X4. (648 aa)
CACNG4Calcium voltage-gated channel auxiliary subunit gamma 4. (321 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit isoform X2. (326 aa)
SHISA7Protein shisa-7. (283 aa)
DISC1Disrupted in schizophrenia 1 protein. (851 aa)
DMTNDematin. (406 aa)
ENSVVUP00000009671annotation not available (107 aa)
GRID2Glutamate receptor ionotropic, delta-2 isoform X1. (922 aa)
SYNPOSynaptopodin isoform X1. (925 aa)
LOC112908207Microtubule-associated protein 1B-like. (103 aa)
MAP1BMicrotubule-associated protein 1B. (2412 aa)
LRRC4Leucine-rich repeat-containing protein 4. (654 aa)
RGS9Regulator of G-protein signaling 9 isoform X1. (675 aa)
HOMER3Homer protein homolog 3 isoform X1. (360 aa)
ADD3Gamma-adducin isoform X1. (706 aa)
DBNLDrebrin-like protein isoform X3. (518 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (403 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X3; Belongs to the protein kinase superfamily. (383 aa)
FBXO45F-box/SPRY domain-containing protein 1. (107 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ENSVVUP00000011849annotation not available (98 aa)
LRRC7Leucine-rich repeat-containing protein 7 isoform X1. (1345 aa)
LOC112910522Leucine-rich repeat-containing protein 7-like. (242 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
ERBB4Receptor protein-tyrosine kinase. (1249 aa)
TSC2Tuberin isoform X8. (1790 aa)
RTN4Reticulon. (993 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C. (1187 aa)
SYT12Synaptotagmin-12. (421 aa)
LRFN4Leucine-rich repeat and fibronectin type-III domain-containing protein 4. (636 aa)
LIN7AProtein lin-7 homolog A. (293 aa)
CLSTN3Calsyntenin-3. (957 aa)
PAK3Non-specific serine/threonine protein kinase. (547 aa)
EIF3AEukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (1350 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1458 aa)
ENSVVUP00000015434annotation not available (1708 aa)
ITPR1-2Inositol 1,4,5-trisphosphate receptor type 1. (1018 aa)
SHANK1SH3 and multiple ankyrin repeat domains protein 1. (2149 aa)
LRRC4BLeucine-rich repeat-containing protein 4B. (717 aa)
RNF19ARBR-type E3 ubiquitin transferase. (838 aa)
LRFN5Leucine-rich repeat and fibronectin type-III domain-containing protein 5. (719 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X2. (1037 aa)
DNAJC6Putative tyrosine-protein phosphatase auxilin isoform X1. (1011 aa)
RS1Retinoschisin. (236 aa)
DCCNetrin receptor DCC isoform X4. (1374 aa)
ENSVVUP00000020942annotation not available (127 aa)
PDE4BPhosphodiesterase. (547 aa)
GRIK2Glutamate receptor ionotropic, kainate 2 isoform X1. (859 aa)
PPP1R9ANeurabin-1 isoform X4. (1342 aa)
NETO2Neuropilin and tolloid-like protein 2. (506 aa)
ENSVVUP00000021885annotation not available (135 aa)
SLC30A3Zinc transporter 3. (388 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1116 aa)
USP50Inactive ubiquitin carboxyl-terminal hydrolase 50; Belongs to the peptidase C19 family. (355 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (470 aa)
DLG2-2Disks large homolog 2 isoform X1. (103 aa)
MPP2MAGUK p55 subfamily member 2 isoform X1; Belongs to the MAGUK family. (610 aa)
DNM2Dynamin-2 isoform X5; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (872 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1457 aa)
ENSVVUP00000024337annotation not available (180 aa)
CTNND2Catenin delta-2. (754 aa)
LOC112934252Catenin delta-2-like isoform X1. (227 aa)
LRRC4CLeucine-rich repeat-containing protein 4C. (640 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
ALS2Alsin isoform X1. (1657 aa)
ENSVVUP00000025132annotation not available (150 aa)
NPTNNeuroplastin. (361 aa)
INSYN1UPF0583 protein C15orf59 homolog isoform X1. (338 aa)
ENSVVUP00000025272annotation not available (56 aa)
NETO1Neuropilin and tolloid-like protein 1 isoform X1. (538 aa)
GRM5LOW QUALITY PROTEIN: metabotropic glutamate receptor 5. (1145 aa)
BCRBreakpoint cluster region protein. (1367 aa)
SHISA9Protein shisa-9. (274 aa)
ENSVVUP00000026460annotation not available (272 aa)
PCLOProtein piccolo. (5036 aa)
SLITRK1SLIT and NTRK-like protein 1. (696 aa)
PKP4Plakophilin-4 isoform X1. (1208 aa)
NRGNNeurogranin. (78 aa)
GRIK4Glutamate receptor ionotropic, kainate 4 isoform X1. (1013 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
CABP1Calcium-binding protein 1. (280 aa)
PDZD2PDZ domain-containing protein 2. (1810 aa)
GAP43Neuromodulin isoform X4. (251 aa)
ENSVVUP00000030418annotation not available (174 aa)
DROSHARibonuclease 3 isoform X1. (1374 aa)
SYNDIG1Synapse differentiation-inducing gene protein 1 isoform X1. (372 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
SCRIBProtein scribble homolog. (1517 aa)
PRR12Proline-rich protein 12. (1983 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1250 aa)
PALMParalemmin-1. (291 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (314 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (917 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (406 aa)
ADD1Alpha-adducin isoform X1. (783 aa)
PICK1PRKCA-binding protein. (609 aa)
GSG1LGerm cell-specific gene 1-like protein isoform X1. (176 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CLSTN1Calsyntenin-1. (982 aa)
BACE1Beta-secretase 1 isoform X1; Belongs to the peptidase A1 family. (501 aa)
PRRT1LOW QUALITY PROTEIN: proline-rich transmembrane protein 1. (83 aa)
HOMER1Homer protein homolog 1 isoform X1. (376 aa)
CADM1Cell adhesion molecule 1 isoform X2. (484 aa)
DGCR8Microprocessor complex subunit DGCR8. (778 aa)
LZTS3Leucine zipper putative tumor suppressor 3 isoform X2. (673 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1825 aa)
SYNGAP1ras/Rap GTPase-activating protein SynGAP isoform X1. (1334 aa)
MAPK8IP2C-Jun-amino-terminal kinase-interacting protein 2. (789 aa)
SHANK3LOW QUALITY PROTEIN: SH3 and multiple ankyrin repeat domains protein 3. (1667 aa)
GRID1Glutamate receptor ionotropic, delta-1. (816 aa)
ENSVVUP00000036027annotation not available (110 aa)
DBN1Drebrin. (779 aa)
CLSTN2Calsyntenin-2. (942 aa)
LRFN2Leucine-rich repeat and fibronectin type-III domain-containing protein 2 isoform X1. (801 aa)
DCLK1Serine/threonine-protein kinase DCLK1 isoform X6; Belongs to the protein kinase superfamily. (423 aa)
DCLK1-2Serine/threonine-protein kinase DCLK1 isoform X7. (329 aa)
ENSVVUP00000037390annotation not available (101 aa)
NCS1Neuronal calcium sensor 1. (194 aa)
DLG4Disks large homolog 4 isoform X5; Belongs to the MAGUK family. (724 aa)
FXR2Fragile X mental retardation syndrome-related protein 2. (908 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
EFNB3ephrin-B3 isoform X1; Belongs to the ephrin family. (340 aa)
SYT9Synaptotagmin-9. (501 aa)
AKAP5A-kinase anchor protein 5. (428 aa)
ADD2Beta-adducin. (722 aa)
TSC1Hamartin isoform X1. (1168 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
BSNProtein bassoon isoform X1. (4030 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (987 aa)
CAMK2N1Calcium/calmodulin-dependent protein kinase II inhibitor 1. (78 aa)
SH2D5SH2 domain-containing protein 5 isoform X2. (428 aa)
ADCY1Adenylate cyclase type 1-like. (919 aa)
RTN3Reticulon. (235 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SHISA6Protein shisa-6. (265 aa)
ENSVVUP00000042010annotation not available (230 aa)
ARHGAP44Rho GTPase-activating protein 44 isoform X1. (876 aa)
SLITRK3SLIT and NTRK-like protein 3 isoform X1. (1001 aa)
RNF112RING finger protein 112. (572 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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