STRINGSTRING
RNF34 RNF34 DDX3Y DDX3Y MAPK7 MAPK7 BMP4 BMP4 LGALS3 LGALS3 SRC SRC IL1B IL1B RELA RELA PELI3 PELI3 FAIM FAIM PARK7 PARK7 FGF10 FGF10 SFRP2 SFRP2 FGB FGB HTT HTT CSF2 CSF2 IL4 IL4 SCG2 SCG2 PSME3 PSME3 HMOX1 HMOX1 FAIM2 FAIM2 GSK3B GSK3B GCLM GCLM UNC5B UNC5B ITPRIPL2 ITPRIPL2 TNF TNF RFFL RFFL HGF HGF TGFBR1 TGFBR1 RIPK1 RIPK1 EYA4 EYA4 EYA1 EYA1 CFLAR CFLAR STRADB STRADB SGK3 SGK3 PHIP PHIP RPS6KB1 RPS6KB1 COL2A1 COL2A1 GATA1 GATA1 RB1CC1 RB1CC1 AR AR SH3RF1 SH3RF1 EYA2 EYA2 PEA15 PEA15 PAK5 PAK5 ITGA6 ITGA6 LOC112923831 LOC112923831 RAF1 RAF1 ZC3HC1 ZC3HC1 EYA3 EYA3 IFI6 IFI6 BIRC6 BIRC6 DDX3X DDX3X NOL3 NOL3 SIAH2 SIAH2 YAP1 YAP1 ZMYND11 ZMYND11 ITGAV ITGAV TMBIM1 TMBIM1 LMNA LMNA ARHGEF2 ARHGEF2 ITPRIP ITPRIP CTTN CTTN GDNF GDNF TNFAIP3 TNFAIP3 GFRAL GFRAL IL19 IL19 IL7 IL7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (412 aa)
DDX3YATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (627 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (409 aa)
LGALS3Galectin. (336 aa)
SRCTyrosine-protein kinase. (536 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
RELATranscription factor p65 isoform X2. (542 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
FAIMFas apoptotic inhibitory molecule 1 isoform X1. (243 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
HTTHuntingtin. (3108 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (147 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
SCG2Secretogranin-2. (615 aa)
PSME3Proteasome activator complex subunit 3. (247 aa)
HMOX1Heme oxygenase 1. (377 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (332 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (459 aa)
GCLMGlutamate--cysteine ligase regulatory subunit. (274 aa)
UNC5BNetrin receptor UNC5B. (1106 aa)
ITPRIPL2LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (508 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X2. (386 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (732 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (509 aa)
STRADBSTE20-related kinase adapter protein beta. (415 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
PHIPPH-interacting protein. (1821 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
COL2A1Collagen alpha-1(II) chain. (1147 aa)
GATA1Erythroid transcription factor. (412 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
ARAndrogen receptor. (900 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (882 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (553 aa)
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
PAK5Non-specific serine/threonine protein kinase. (775 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1082 aa)
LOC112923831Protein lifeguard 2-like; Belongs to the BI1 family. (219 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ZC3HC1Nuclear-interacting partner of ALK. (482 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
IFI6Interferon alpha-inducible protein 6. (269 aa)
BIRC6Baculoviral IAP repeat-containing protein 6 isoform X3. (4983 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
NOL3Nucleolar protein 3 isoform X5. (222 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (758 aa)
YAP1Transcriptional coactivator YAP1. (431 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (617 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1054 aa)
TMBIM1Protein lifeguard 3; Belongs to the BI1 family. (311 aa)
LMNALamin; Belongs to the intermediate filament family. (685 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X3. (1175 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein. (584 aa)
CTTNSrc substrate cortactin isoform X2. (504 aa)
GDNFGlial cell line-derived neurotrophic factor. (198 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X2. (854 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (394 aa)
IL19Interleukin-19. (177 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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